Matteo Rivelli1, Eduardo Fernandes2, Cristian Conti1, Laura Bernardoni3, Sara Pecori4, Sara Cingarlini5, Corrado Pedrazzani6,7. 1. Unit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Verona University, Verona, Italy. 2. Division of Minimally Invasive, General and Robotic Surgery, University of Illinois at Chicago, Chicago, USA. 3. Digestive Endoscopy Unit, The Pancreas Institute, Verona University and Hospital Trust, Verona, Italy. 4. Pathological Anatomy Section, Department of Diagnostics and Public Health, Verona University and Hospital Trust, Verona, Italy. 5. Oncology Section, Department of Oncology, Verona University and Hospital Trust, Verona, Italy. 6. Unit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Verona University, Verona, Italy. corrado.pedrazzani@univr.it. 7. Unit of General and Hepatobiliary Surgery, University Hospital "G.B. Rossi", Piazzale "L. Scuro" 10, 37134, Verona, Italy. corrado.pedrazzani@univr.it.
Abstract
BACKGROUND: Synovial sarcoma (SS) is a rare soft tissue tumor. Among different anatomical locations where it can be found, gastric localization is a very uncommon one. Based on soft tissue sarcoma guidelines, complete tumor excision is considered the main treatment approach. Depending on size and localization of the tumor, both wedge and major gastric resections have been performed in the past for the treatment of this condition. CASE PRESENTATION: We present the case of a 43-year-old woman who underwent a laparoscopic intragastric excision of a gastric 10-mm SS located nearby the esophagogastric junction. Pathology examination confirmed the presence of a SS. The resected specimen confirmed margin-free excision of a monophasic spindle cell neoplasm invading the submucosa and presenting the rearrangement of SS18 gene at fluorescence in situ hybridization (FISH). No adjuvant treatment was offered, and 18 months after surgery, the patient was alive and disease free. CONCLUSIONS: This represents the first case reported in literature of a laparoscopic intragastric resection for a gastric SS. This approach allowed to obtain a full thickness radical tumor resection with the advantages of minimally invasive and organ preserving surgery.
BACKGROUND:Synovial sarcoma (SS) is a rare soft tissue tumor. Among different anatomical locations where it can be found, gastric localization is a very uncommon one. Based on soft tissue sarcoma guidelines, complete tumor excision is considered the main treatment approach. Depending on size and localization of the tumor, both wedge and major gastric resections have been performed in the past for the treatment of this condition. CASE PRESENTATION: We present the case of a 43-year-old woman who underwent a laparoscopic intragastric excision of a gastric 10-mm SS located nearby the esophagogastric junction. Pathology examination confirmed the presence of a SS. The resected specimen confirmed margin-free excision of a monophasic spindle cell neoplasm invading the submucosa and presenting the rearrangement of SS18 gene at fluorescence in situ hybridization (FISH). No adjuvant treatment was offered, and 18 months after surgery, the patient was alive and disease free. CONCLUSIONS: This represents the first case reported in literature of a laparoscopic intragastric resection for a gastric SS. This approach allowed to obtain a full thickness radical tumor resection with the advantages of minimally invasive and organ preserving surgery.
Authors: Andrea Mafficini; Lodewijk A A Brosens; Maria L Piredda; Cristian Conti; Paola Mattiolo; Giulia Turri; Maria G Mastrosimini; Sara Cingarlini; Stefano F Crinò; Matteo Fassan; Paola Piccoli; Michele Simbolo; Alessia Nottegar; Rita T Lawlor; Alfredo Guglielmi; Aldo Scarpa; Corrado Pedrazzani; Claudio Luchini Journal: Fam Cancer Date: 2022-01-25 Impact factor: 2.375