Brooke E Kohler1,2, Emmah Baque1,3, Carolina X Sandler1,2,4, Denise S K Brookes1,2, Caroline O Terranova1,2, Matthew Rixon5, Tim Hassall6, Stewart G Trost7,8. 1. Institute of Health and Biomedical Innovation at the Queensland Centre for Children's Health Research, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. 2. School of Exercise and Nutrition Science, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. 3. School of Allied Health Sciences, Griffith University, Gold Coast, Queensland, Australia. 4. UNSW Fatigue Research Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia. 5. School of Clinical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. 6. Queensland Children's Hospital, Brisbane, Queensland, Australia. 7. Institute of Health and Biomedical Innovation at the Queensland Centre for Children's Health Research, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. s.trost@qut.edu.au. 8. School of Exercise and Nutrition Science, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. s.trost@qut.edu.au.
Abstract
BACKGROUND:Posterior fossa brain tumors (PFBT) are the most common solid tumor in children. Recent increases in survival rates are encouraging; however, survivors may experience a plethora of disease- and treatment-related complications that can persist into adulthood. Therapeutic exercise interventions have been shown to improve quality of survivorship in other pediatric cancer diagnoses. There is also evidence that goal-directed interventions are effective at improving motor activities, function, and self-care in children with complex health conditions. Yet, there is currently no evidence on the efficacy of goal-directed therapeutic exercise in pediatric PFBT survivors. The Physical ACTivity in Survivorship (PACTS) study aims to investigate the effects of a novel goal-directed therapeutic exercise program on cardiorespiratory fitness and physical activity-related goal attainment in pediatric survivors of PFBT. METHOD: PFBT survivors, aged five to 17 years, who underwent surgery at least 12 months earlier and completedradiation therapy and/or chemotherapy at least 6 months prior will be recruited from the Queensland Children's Hospital (Brisbane, Australia) (target n = 48). Following baseline assessment, participants are randomized into either the intervention or usual care group. The intervention group will receive weekly individualized, goal-directed exercise therapy delivered face-to-face for 12 weeks, along with an accompanying home-based program (three sessions per week). Outcomes will be assessed at baseline, immediately post-intervention, and at 6- and 12-months post-intervention. The primary outcomes are cardiorespiratory fitness (Peak VO2) and physical activity-related goal attainment. Secondary outcomes are cardiorespiratory endurance, high-level mobility skills, functional muscle strength, habitual physical activity, gait, balance, quality of life, fatigue, participation, perceived movement skill competence and parameters of body composition. DISCUSSION: PACTS is the first study to investigate the efficacy of goal-directed therapeutic exercise in children with PFBT and provide evidence needed to inform clinical practice recommendations for managing quality of survivorship in PFBT survivors. TRIAL REGISTRATION: ACTRN12619000841178 .
RCT Entities:
BACKGROUND: Posterior fossa brain tumors (PFBT) are the most common solid tumor in children. Recent increases in survival rates are encouraging; however, survivors may experience a plethora of disease- and treatment-related complications that can persist into adulthood. Therapeutic exercise interventions have been shown to improve quality of survivorship in other pediatric cancer diagnoses. There is also evidence that goal-directed interventions are effective at improving motor activities, function, and self-care in children with complex health conditions. Yet, there is currently no evidence on the efficacy of goal-directed therapeutic exercise in pediatric PFBT survivors. The Physical ACTivity in Survivorship (PACTS) study aims to investigate the effects of a novel goal-directed therapeutic exercise program on cardiorespiratory fitness and physical activity-related goal attainment in pediatric survivors of PFBT. METHOD:PFBT survivors, aged five to 17 years, who underwent surgery at least 12 months earlier and completed radiation therapy and/or chemotherapy at least 6 months prior will be recruited from the Queensland Children's Hospital (Brisbane, Australia) (target n = 48). Following baseline assessment, participants are randomized into either the intervention or usual care group. The intervention group will receive weekly individualized, goal-directed exercise therapy delivered face-to-face for 12 weeks, along with an accompanying home-based program (three sessions per week). Outcomes will be assessed at baseline, immediately post-intervention, and at 6- and 12-months post-intervention. The primary outcomes are cardiorespiratory fitness (Peak VO2) and physical activity-related goal attainment. Secondary outcomes are cardiorespiratory endurance, high-level mobility skills, functional muscle strength, habitual physical activity, gait, balance, quality of life, fatigue, participation, perceived movement skill competence and parameters of body composition. DISCUSSION: PACTS is the first study to investigate the efficacy of goal-directed therapeutic exercise in children with PFBT and provide evidence needed to inform clinical practice recommendations for managing quality of survivorship in PFBT survivors. TRIAL REGISTRATION: ACTRN12619000841178 .
Entities:
Keywords:
Cardiorespiratory fitness; Children; Goal attainment; Oncology; Physical activity; Quality of life
Authors: Wendy Coster; Gary Bedell; Mary Law; Mary Alunkal Khetani; Rachel Teplicky; Kendra Liljenquist; Kara Gleason; Ying-Chia Kao Journal: Dev Med Child Neurol Date: 2011-11 Impact factor: 5.449
Authors: Shoshana R Rath; Treya M Long; Natasha L Bear; Gordon C P Miles; Andrew M Bullock; Nicholas G Gottardo; Catherine H Cole; Louise H Naylor; Catherine S Y Choong Journal: J Adolesc Young Adult Oncol Date: 2018-03-22 Impact factor: 2.223
Authors: Brooke E Kohler; Carolina X Sandler; Emmah Baque; Natalie K Bradford; Stewart G Trost Journal: Front Pediatr Date: 2022-09-16 Impact factor: 3.569