| Literature DB >> 33647438 |
Vera D'Aloisio1, Paolo Dognini1, Gillian A Hutcheon1, Christopher R Coxon2.
Abstract
As of 2020, there were >100 approved peptides with therapeutic or diagnostic applications. However, a complete database providing information on marketed peptides is not freely available, making the peptide chemists' job of designing future peptide drug candidates challenging. Unlike the rules for small-molecule drugs, there is no general set of guidelines for designing a successful peptide-based drug. In this review, together with our freely available database (PepTherDia, http://peptherdia.herokuapp.com), we provide insights into what a successful peptide therapeutic or diagnostic agent looks like and lay the foundation for establishing a set of rules to help future medicinal chemists to design peptide candidates with increased approval rates.Entities:
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Year: 2021 PMID： 33647438 DOI： 10.1016/j.drudis.2021.02.019
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851