Deepak Rai1, Jyotsana Singh2, Thimmappa Somashekharappa3, Ajit Singh4. 1. Senior Resident, Department of Orthopaedics, Trauma Center, BHU, 221005 Varanasi, India. 2. Junior Resident, Department of Pediatrics, JNMC, AMU, 202002 Aligarh, India. 3. Professor, Department of Orthopaedics, Rohilkhand Medical College, 243006 Bareilly, India. 4. Professor, Department of Orthopaedics, S.S. Hospital, BHU, 221005 Varanasi, India.
Abstract
OBJECTIVE: PRP is produced by centrifugation of whole blood containing highly concentrated platelets, associated growth factors, and other bioactive agents which has been shown to provide some symptomatic relief in early knee osteoarthritis (OA). The principal objective of our study was to evaluate the effectiveness and safety of standardized intra-articular injection of autologous PRP in early osteoarthritis knee. METHODS: A total of 98 eligible symptomatic patients received two injections of standardized PRP 3 weeks apart. Clinical outcomes were evaluated using the VAS and Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire before treatment and at 6 weeks, 3 months, 6 months, and 1 year after treatment. Secondary objectives were safety (side effects), and the effect of PRP on the different grades of knee degeneration. RESULTS: There was a statistically significant improvement in mean VAS and WOMAC scores at 6 weeks, 3 months, 6 months, and slight loss of improvement at 1 year follow-up. There was also a correlation between the degree of degeneration and improvement in the mean scores. The decrease in mean pain score is more in grades 1 and 2 (early OA) than in grade 3. The intraarticular injection is safe, with no major complications. CONCLUSION: PRP is a safe and effective biological regenerative therapy for early OA Knees. It provides a significant clinical improvement in patients with some loss of improvement with time. More studies will be needed to confirm our findings.
OBJECTIVE:PRP is produced by centrifugation of whole blood containing highly concentrated platelets, associated growth factors, and other bioactive agents which has been shown to provide some symptomatic relief in early knee osteoarthritis (OA). The principal objective of our study was to evaluate the effectiveness and safety of standardized intra-articular injection of autologous PRP in early osteoarthritis knee. METHODS: A total of 98 eligible symptomatic patients received two injections of standardized PRP 3 weeks apart. Clinical outcomes were evaluated using the VAS and Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire before treatment and at 6 weeks, 3 months, 6 months, and 1 year after treatment. Secondary objectives were safety (side effects), and the effect of PRP on the different grades of knee degeneration. RESULTS: There was a statistically significant improvement in mean VAS and WOMAC scores at 6 weeks, 3 months, 6 months, and slight loss of improvement at 1 year follow-up. There was also a correlation between the degree of degeneration and improvement in the mean scores. The decrease in mean pain score is more in grades 1 and 2 (early OA) than in grade 3. The intraarticular injection is safe, with no major complications. CONCLUSION:PRP is a safe and effective biological regenerative therapy for early OA Knees. It provides a significant clinical improvement in patients with some loss of improvement with time. More studies will be needed to confirm our findings.
Authors: Lawrence P Lai; Todd P Stitik; Patrick M Foye; John S Georgy; Varun Patibanda; Boqing Chen Journal: PM R Date: 2015-02-14 Impact factor: 2.298
Authors: E Anitua; M Sánchez; A T Nurden; M M Zalduendo; M de la Fuente; J Azofra; I Andía Journal: Rheumatology (Oxford) Date: 2007-10-17 Impact factor: 7.580
Authors: Alex Yuan; Erica L Farber; Ana Lia Rapoport; Desiree Tejada; Roman Deniskin; Novrouz B Akhmedov; Debora B Farber Journal: PLoS One Date: 2009-03-06 Impact factor: 3.240