Literature DB >> 33644874

CrossTalk opposing view: Ketone bodies are not an important metabolic fuel for the heart.

Manoja K Brahma1, Adam R Wende2, Kyle S McCommis3.   

Abstract

Entities:  

Keywords:  heart; ketone bodies; metabolism; mitochondria

Mesh：

Substances：

Year:  2021        PMID： 33644874      PMCID： PMC8408278          DOI： 10.1113/JP281005

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   6.228


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  29 in total

1.  Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.

Authors:  Jie Yan; Martin E Young; Lei Cui; Gary D Lopaschuk; Ronglih Liao; Rong Tian
Journal:  Circulation       Date:  2009-05-18       Impact factor: 29.690

2.  Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment.

Authors:  Anna E Wentz; D André d'Avignon; Mary L Weber; David G Cotter; Jason M Doherty; Robnet Kerns; Rakesh Nagarajan; Naveen Reddy; Nandakumar Sambandam; Peter A Crawford
Journal:  J Biol Chem       Date:  2010-06-07       Impact factor: 5.157

3.  Comprehensive quantification of fuel use by the failing and nonfailing human heart.

Authors:  Danielle Murashige; Cholsoon Jang; Michael Neinast; Jonathan J Edwards; Alexis Cowan; Matthew C Hyman; Joshua D Rabinowitz; David S Frankel; Zolt Arany
Journal:  Science       Date:  2020-10-16       Impact factor: 47.728

4.  Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy.

Authors:  Kimberly A Stowe; Shawn C Burgess; Matthew Merritt; A Dean Sherry; Craig R Malloy
Journal:  FEBS Lett       Date:  2006-06-30       Impact factor: 4.124

5.  Chronic exposure to beta-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes.

Authors:  A Tardif; N Julien; A Pelletier; G Thibault; A K Srivastava; J L Chiasson; L Coderre
Journal:  Am J Physiol Endocrinol Metab       Date:  2001-12       Impact factor: 4.310

6.  In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle.

Authors:  Heather L Petrick; Henver S Brunetta; Chris Pignanelli; Everson A Nunes; Luc J C van Loon; Jamie F Burr; Graham P Holloway
Journal:  J Physiol       Date:  2020-08-19       Impact factor: 5.182

7.  beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content.

Authors:  William C Stanley; Steven R Meadows; Krista M Kivilo; Bridgette A Roth; Gary D Lopaschuk
Journal:  Am J Physiol Heart Circ Physiol       Date:  2003-10       Impact factor: 4.733

8.  Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration.

Authors:  F M Jeffrey; V Diczku; A D Sherry; C R Malloy
Journal:  Basic Res Cardiol       Date:  1995 Sep-Oct       Impact factor: 17.165

9.  Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.

Authors:  Rebecca C Schugar; Ashley R Moll; D André d'Avignon; Carla J Weinheimer; Attila Kovacs; Peter A Crawford
Journal:  Mol Metab       Date:  2014-08-13       Impact factor: 7.422

10.  Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization.

Authors:  Manoja K Brahma; Chae-Myeong Ha; Mark E Pepin; Sobuj Mia; Zhihuan Sun; John C Chatham; Kirk M Habegger; Evan Dale Abel; Andrew J Paterson; Martin E Young; Adam R Wende
Journal:  J Am Heart Assoc       Date:  2020-07-30       Impact factor: 5.501
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  1 in total

1.  Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming.

Authors:  Danyang Chong; Yayun Gu; Tongyu Zhang; Yu Xu; Dandan Bu; Zhong Chen; Na Xu; Liangkui Li; Xiyu Zhu; Haiquan Wang; Yangqing Li; Feng Zheng; Dongjin Wang; Peng Li; Li Xu; Zhibin Hu; Chaojun Li
Journal:  Cell Discov       Date:  2022-10-11       Impact factor: 38.079
  1 in total

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