Literature DB >> 33644779

Stepwise Tfh cell differentiation revisited: new advances and long-standing questions.

Andrew R Schroeder1, Fangming Zhu1, Hui Hu1.   

Abstract

T follicular helper (Tfh) cells play an essential role in germinal center formation and the generation of high-affinity antibodies. Studies have proposed that Tfh cell differentiation is a multi-step process. However, it is still not fully understood how a subset of activated CD4+ T cells begin to express CXCR5 during the early stage of the response and, shortly after, how some CXCR5+ precursor Tfh (pre-Tfh) cells enter B cell follicles and differentiate further into germinal center Tfh (GC-Tfh) cells while others have a different fate. In this mini-review, we summarize the recent advances surrounding these two aspects of Tfh cell differentiation and discuss related long-standing questions, including Tfh memory.

Entities:  

Keywords:  CD4 memory; CXCR5; TCR; Tfh; germinal center; metabolism; stepwise differentiation; transcription factor

Year:  2021        PMID： 33644779      PMCID： PMC7894273          DOI： 10.12703/r/10-3

Source DB:  PubMed          Journal:  Fac Rev        ISSN： 2732-432X


  173 in total

1.  Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150).

Authors:  Isharat Yusuf; Robin Kageyama; Laurel Monticelli; Robert J Johnston; Daniel Ditoro; Kyle Hansen; Burton Barnett; Shane Crotty
Journal:  J Immunol       Date:  2010-06-04       Impact factor: 5.422

2.  The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok.

Authors:  Thomas Ciucci; Melanie S Vacchio; Yayi Gao; Francesco Tomassoni Ardori; Julian Candia; Monika Mehta; Yongmei Zhao; Bao Tran; Marion Pepper; Lino Tessarollo; Dorian B McGavern; Rémy Bosselut
Journal:  Immunity       Date:  2019-01-09       Impact factor: 31.745

3.  The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance.

Authors:  Alexandre P Meli; Ghislaine Fontés; Danielle T Avery; Scott A Leddon; Mifong Tam; Michael Elliot; Andre Ballesteros-Tato; Jim Miller; Mary M Stevenson; Deborah J Fowell; Stuart G Tangye; Irah L King
Journal:  Immunity       Date:  2016-10-18       Impact factor: 31.745

4.  The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate.

Authors:  Veena Krishnamoorthy; Sunil Kannanganat; Mark Maienschein-Cline; Sarah L Cook; Jianjun Chen; Neil Bahroos; Evelyn Sievert; Emily Corse; Anita Chong; Roger Sciammas
Journal:  Immunity       Date:  2017-09-19       Impact factor: 31.745

5.  Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.

Authors:  Roza I Nurieva; Yeonseok Chung; Daehee Hwang; Xuexian O Yang; Hong Soon Kang; Li Ma; Yi-hong Wang; Stephanie S Watowich; Anton M Jetten; Qiang Tian; Chen Dong
Journal:  Immunity       Date:  2008-07-03       Impact factor: 31.745

6.  Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.

Authors:  Noah J Tubo; Antonio J Pagán; Justin J Taylor; Ryan W Nelson; Jonathan L Linehan; James M Ertelt; Eric S Huseby; Sing Sing Way; Marc K Jenkins
Journal:  Cell       Date:  2013-05-09       Impact factor: 41.582

7.  TOX is a critical regulator of tumour-specific T cell differentiation.

Authors:  Andrew C Scott; Friederike Dündar; Paul Zumbo; Smita S Chandran; Christopher A Klebanoff; Mojdeh Shakiba; Prerak Trivedi; Laura Menocal; Heather Appleby; Steven Camara; Dmitriy Zamarin; Tyler Walther; Alexandra Snyder; Matthew R Femia; Elizabeth A Comen; Hannah Y Wen; Matthew D Hellmann; Niroshana Anandasabapathy; Yong Liu; Nasser K Altorki; Peter Lauer; Olivier Levy; Michael S Glickman; Jonathan Kaye; Doron Betel; Mary Philip; Andrea Schietinger
Journal:  Nature       Date:  2019-06-17       Impact factor: 49.962

8.  Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo.

Authors:  Robert A Benson; Megan K L MacLeod; Benjamin G Hale; Agapitos Patakas; Paul Garside; James M Brewer
Journal:  Elife       Date:  2015-08-10       Impact factor: 8.140

9.  Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.

Authors:  Xindong Liu; Xin Chen; Bo Zhong; Aibo Wang; Xiaohu Wang; Fuliang Chu; Roza I Nurieva; Xiaowei Yan; Ping Chen; Laurens G van der Flier; Hiroko Nakatsukasa; Sattva S Neelapu; Wanjun Chen; Hans Clevers; Qiang Tian; Hai Qi; Lai Wei; Chen Dong
Journal:  Nature       Date:  2014-01-19       Impact factor: 49.962

10.  B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.

Authors:  E Nicole Arroyo; Marion Pepper
Journal:  J Exp Med       Date:  2020-02-03       Impact factor: 14.307
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  2 in total

Review 1.  The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells.

Authors:  Yifei Wang; Qin Tian; Lilin Ye
Journal:  Front Cell Infect Microbiol       Date:  2022-07-14       Impact factor: 6.073

Review 2.  Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses.

Authors:  Justine Poirot; Jasna Medvedovic; Coline Trichot; Vassili Soumelis
Journal:  Eur J Immunol       Date:  2021-10-20       Impact factor: 6.688
  2 in total

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