| Literature DB >> 3364462 |
L Lapuerta1, N Chacos, J R Falck, H Jacobson, J H Capdevila.
Abstract
Arachidonic acid is oxidized by the microsomal cytochrome P-450 monooxygenases of rabbit kidney cortex and medulla to products that include W and W-1 alcohols and several epoxyacids. In vivo administration of deoxycorticosterone acetate results in a time dependent and selective induction of the arachidonic acid W/W-1 oxygenase activity of cortex and medulla microsomal fractions (145% and 220% of controls, respectively). Initial segmental analysis shows the presence of an active epoxygenase activity in the isolated rabbit pars recta and its in vitro activation by p-aminohippuric acid.Entities:
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Year: 1988 PMID： 3364462 DOI： 10.1097/00000441-198804000-00010
Source DB: PubMed Journal: Am J Med Sci ISSN： 0002-9629 Impact factor: 2.378