Gabriella Liszkay1, Zoltan Kiss2, Roland Gyulai3, Judit Oláh4,5, Péter Holló6, Gabriella Emri7, András Csejtei8, István Kenessey1, Angela Benedek2, Zoltán Polányi2, Zsófia Nagy-Erdei2, Andrea Daniel2, Kata Knollmajer2, Máté Várnai2,9, Zoltán Vokó9, Balázs Nagy9, György Rokszin10, Ibolya Fábián10,11, Zsófia Barcza12, Csaba Polgár13,14. 1. Department of Dermato-Oncology, National Institute of Oncology, Budapest, Hungary. 2. MSD Pharma Hungary Ltd., Budapest, Hungary. 3. Department of Dermatology, Venereology and Oncodermatology, Faculty of Medicine, University of Pécs, Pécs, Hungary. 4. Department of Oncotherapy, University of Szeged, Szeged, Hungary. 5. Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary. 6. Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary. 7. Department of Dermatology, University of Debrecen, Debrecen, Hungary. 8. Department of Oncoradiology, Markusovszky University Teaching Hospital, Szombathely, Hungary. 9. Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary. 10. RxTarget Ltd., Szolnok, Hungary. 11. Biomathematics and Informatics Department, University of Veterinary Medicine, Budapest, Hungary. 12. Syntesia Medical Communications Ltd., Budapest, Hungary. 13. Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary. 14. Department of Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Abstract
BACKGROUND: The incidence of malignant melanoma has continually increased during the past few decades, however, certain reports suggest a recent change in trends. The aim of our study was to examine the epidemiology of melanoma in Hungary. METHODS: This nationwide, retrospective, longitudinal study included melanoma patients diagnosed between 1 January 2009 and 31 December 2019 using the databases of the National Health Insurance Fund (NHIF) and Central Statistical Office (CSO) of Hungary. Age-standardized incidence and cause-specific mortality rates were calculated. RESULTS: We identified 2,426 and 2,414 new melanoma cases in 2011 and in 2019. Age-standardized incidence rates were higher in males and varied between 28.28 and 34.57/100,000 person-years (PYs), and between 22.63 and 26.72/100,000 PYs in females. We found 16.14 and 18.82% increases in male and female incidence rates from 2011 to 2015 (p=0.067 and p<0.001, respectively), and 12.77 and 11.35% decreases from 2015 to 2019 (p=0.062 and p=0.004, respectively). The change of incidence trends (2011-2015 vs. 2015-2019) was significant in females (p=0.002) and in the total melanoma population (p=0.011), but not in the male population (p=0.063). A 16.55% (95% CI: -27.07 to -4.59; p=0.013) decrease in mortality rates was found in the overall melanoma population. CONCLUSIONS: We observed a significant trend change in melanoma incidence in the female and total melanoma population, and a significant decrease in mortality in the total melanoma population. These changes may be attributed to intensive melanoma awareness campaigns as well as to the increase in screening and access to modern therapies.
BACKGROUND: The incidence of malignant melanoma has continually increased during the past few decades, however, certain reports suggest a recent change in trends. The aim of our study was to examine the epidemiology of melanoma in Hungary. METHODS: This nationwide, retrospective, longitudinal study included melanoma patients diagnosed between 1 January 2009 and 31 December 2019 using the databases of the National Health Insurance Fund (NHIF) and Central Statistical Office (CSO) of Hungary. Age-standardized incidence and cause-specific mortality rates were calculated. RESULTS: We identified 2,426 and 2,414 new melanoma cases in 2011 and in 2019. Age-standardized incidence rates were higher in males and varied between 28.28 and 34.57/100,000 person-years (PYs), and between 22.63 and 26.72/100,000 PYs in females. We found 16.14 and 18.82% increases in male and female incidence rates from 2011 to 2015 (p=0.067 and p<0.001, respectively), and 12.77 and 11.35% decreases from 2015 to 2019 (p=0.062 and p=0.004, respectively). The change of incidence trends (2011-2015 vs. 2015-2019) was significant in females (p=0.002) and in the total melanoma population (p=0.011), but not in the male population (p=0.063). A 16.55% (95% CI: -27.07 to -4.59; p=0.013) decrease in mortality rates was found in the overall melanoma population. CONCLUSIONS: We observed a significant trend change in melanoma incidence in the female and total melanoma population, and a significant decrease in mortality in the total melanoma population. These changes may be attributed to intensive melanoma awareness campaigns as well as to the increase in screening and access to modern therapies.
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Authors: P W Barnes; T M Robson; P J Neale; C E Williamson; R G Zepp; S Madronich; S R Wilson; A L Andrady; A M Heikkilä; G H Bernhard; A F Bais; R E Neale; J F Bornman; M A K Jansen; A R Klekociuk; J Martinez-Abaigar; S A Robinson; Q-W Wang; A T Banaszak; D-P Häder; S Hylander; K C Rose; S-Å Wängberg; B Foereid; W-C Hou; R Ossola; N D Paul; J E Ukpebor; M P S Andersen; J Longstreth; T Schikowski; K R Solomon; B Sulzberger; L S Bruckman; K K Pandey; C C White; L Zhu; M Zhu; P J Aucamp; J B Liley; R L McKenzie; M Berwick; S N Byrne; L M Hollestein; R M Lucas; C M Olsen; L E Rhodes; S Yazar; A R Young Journal: Photochem Photobiol Sci Date: 2022-02-21 Impact factor: 4.328