Hafeez Aderinsayo Adekola1, Idris Nasir Abdullahi2, Anthony Uchenna Emeribe3, Nafiu Faruku2, Leonard Uzairue4, Olusoji Matthew Adeyemi Billyrose5, Halima Ali Shuwa6. 1. Department of Microbiology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria. 2. Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria. 3. Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, University of Calabar, Calabar, Nigeria. 4. Department of Microbiology, Federal University of Agriculture, Abeokuta, Nigeria. 5. Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. 6. University Health Center, Faculty of Health and Medical Sciences, Federal University, Dutse, Nigeria.
Abstract
Background: Nigeria is one of the countries with a high prevalence of measles outbreak in children under 5 years old, despite a history of vaccination. This study aims to determine the prevalence of anti-measles virus IgM and IgG among children under 5 years attending the University of Abuja Teaching Hospital (UATH), Gwagwalada, FCT Abuja, Nigeria. Materials and methods: Whole blood was collected, centrifuged, and serum anti-IgM and anti-IgG against measles virus was analysed using ELISA. Sociodemographic variables and vaccination history of subjects were obtained by interview-based questionnaires. Results: The overall anti-Measles virus IgG and IgM seroprevalences were 29.2% and 14.6%, respectively. The prevalence of measles IgG was significantly associated with the parent's employment status (X 2 =11.67, p=0.008). However, the prevalence of measles virus IgM was significantly associated with children's age (X 2 =16.62, p=0.002), parents' employment status and children's vaccination status (X 2 =7.72, p=0.02). Conclusion: A majority of study participants were not immunised against measles, and a significant number of participants had serological evidence of acute measles virus infection. There is a need for more concerted and massive measles vaccination of children.
Background: Nigeria is one of the countries with a high prevalence of measles outbreak in children under 5 years old, despite a history of vaccination. This study aims to determine the prevalence of anti-measles virus IgM and IgG among children under 5 years attending the University of Abuja Teaching Hospital (UATH), Gwagwalada, FCT Abuja, Nigeria. Materials and methods: Whole blood was collected, centrifuged, and serum anti-IgM and anti-IgG against measles virus was analysed using ELISA. Sociodemographic variables and vaccination history of subjects were obtained by interview-based questionnaires. Results: The overall anti-Measles virus IgG and IgM seroprevalences were 29.2% and 14.6%, respectively. The prevalence of measles IgG was significantly associated with the parent's employment status (X 2 =11.67, p=0.008). However, the prevalence of measles virus IgM was significantly associated with children's age (X 2 =16.62, p=0.002), parents' employment status and children's vaccination status (X 2 =7.72, p=0.02). Conclusion: A majority of study participants were not immunised against measles, and a significant number of participants had serological evidence of acute measlesvirus infection. There is a need for more concerted and massive measles vaccination of children.
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