Xin Huang1,2, Zhi Wen3, Chen-Xing Qi1, Yan Tong1, Yin Shen1,4. 1. Eye Center, Renmin Hospital of Wuhan University, Wuhan, China. 2. Department of Ophthalmology, Jiangxi Provincial People's Hospital, Nanchang, China. 3. Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China. 4. Medical Research Institute, Wuhan University, Wuhan, China.
Abstract
Background: Growing evidence demonstrate that diabetic retinopathy (DR) patients have a high risk of cognitive decline and exhibit abnormal brain activity. However, neuroimaging studies thus far have focused on static cerebral activity changes in DR patients. The characteristics of dynamic cerebral activity in patients with DR are poorly understood. Purpose: The purpose of the study was to investigate the dynamic cerebral activity changes in patients with DR using the dynamic amplitude of low-frequency fluctuation (dALFF) method. Materials and methods: Thirty-four DR patients (18 men and 16 women) and 38 healthy controls (HCs) (18 males and 20 females) closely matched in age, sex, and education were enrolled in this study. The dALFF method was used to investigate dynamic intrinsic brain activity differences between the DR and HC groups. Results: Compared with HCs, DR patients exhibited increased dALFF variability in the right brainstem, left cerebellum_8, left cerebellum_9, and left parahippocampal gyrus. In contrast, DR patients exhibited decreased dALFF variability in the left middle occipital gyrus and right middle occipital gyrus. Conclusion: Our study highlighted that DR patients showed abnormal variability of dALFF in the visual cortices, cerebellum, and parahippocampal gyrus. These findings suggest impaired visual and motor and memory function in DR individuals. Thus, abnormal dynamic spontaneous brain activity might be involved in the pathophysiology of DR.
Background: Growing evidence demonstrate that diabetic retinopathy (DR) patients have a high risk of cognitive decline and exhibit abnormal brain activity. However, neuroimaging studies thus far have focused on static cerebral activity changes in DR patients. The characteristics of dynamic cerebral activity in patients with DR are poorly understood. Purpose: The purpose of the study was to investigate the dynamic cerebral activity changes in patients with DR using the dynamic amplitude of low-frequency fluctuation (dALFF) method. Materials and methods: Thirty-four DR patients (18 men and 16 women) and 38 healthy controls (HCs) (18 males and 20 females) closely matched in age, sex, and education were enrolled in this study. The dALFF method was used to investigate dynamic intrinsic brain activity differences between the DR and HC groups. Results: Compared with HCs, DR patients exhibited increased dALFF variability in the right brainstem, left cerebellum_8, left cerebellum_9, and left parahippocampal gyrus. In contrast, DR patients exhibited decreased dALFF variability in the left middle occipital gyrus and right middle occipital gyrus. Conclusion: Our study highlighted that DR patients showed abnormal variability of dALFF in the visual cortices, cerebellum, and parahippocampal gyrus. These findings suggest impaired visual and motor and memory function in DR individuals. Thus, abnormal dynamic spontaneous brain activity might be involved in the pathophysiology of DR.
Authors: Lieza G Exalto; Geert Jan Biessels; Andrew J Karter; Elbert S Huang; Charles P Quesenberry; Rachel A Whitmer Journal: J Alzheimers Dis Date: 2014 Impact factor: 4.472
Authors: Paul K Mazaika; Stuart A Weinzimer; Nelly Mauras; Bruce Buckingham; Neil H White; Eva Tsalikian; Tamara Hershey; Allison Cato; Tandy Aye; Larry Fox; Darrell M Wilson; Michael J Tansey; William Tamborlane; Daniel Peng; Mira Raman; Matthew Marzelli; Allan L Reiss Journal: Diabetes Date: 2015-10-28 Impact factor: 9.337