Literature DB >> 33643070

Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice.

Jing Li1, Heng Zhang1, Yongqiang Dong2, Xian Wang2, Guang Wang1.   

Abstract

The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance; however, the mechanism of inflammasome activation in adipose tissue remains elusive. In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process. Hcy-induced activation of NLRP3 inflammasomes were observed in adipose tissue during the generation of insulin resistance in vivo. This animal model suggests that diets high in omega-3 fatty acids alter serum and adipose lipid profiles, and in this way, omega-3 fatty acids may reduce adipose tissue inflammation and attenuate insulin resistance.
Copyright © 2021 Li, Zhang, Dong, Wang and Wang.

Entities:  

Keywords:  adipocyte; homocysteine; inflammation; insulin resistance; omega-3 fatty acids

Year:  2021        PMID： 33643070      PMCID： PMC7907609          DOI： 10.3389/fphys.2021.628122

Source DB:  PubMed          Journal:  Front Physiol        ISSN： 1664-042X            Impact factor:   4.566


  34 in total

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Authors:  Makoto Murakami; Yoshitaka Taketomi; Yoshimi Miki; Hiroyasu Sato; Tetsuya Hirabayashi; Kei Yamamoto
Journal:  Prog Lipid Res       Date:  2010-12-24       Impact factor: 16.195

2.  Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis.

Authors:  Jing Dai; Wenjing Li; Lina Chang; Zhenmin Zhang; Chaoshu Tang; Nanping Wang; Yi Zhu; Xian Wang
Journal:  Free Radic Biol Med       Date:  2006-08-30       Impact factor: 7.376

Review 3.  Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets.

Authors:  Yi Fu; Xian Wang; Wei Kong
Journal:  Br J Pharmacol       Date:  2017-09-22       Impact factor: 8.739

4.  NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation.

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Journal:  Biochem Biophys Res Commun       Date:  2017-02-04       Impact factor: 3.575

5.  Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.

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Journal:  J Clin Invest       Date:  2014-12-15       Impact factor: 14.808

6.  Protective role of growth hormone against hyperhomocysteinemia-induced glomerular injury.

Authors:  Caixia Li; Min Xia; Justine M Abais; Xiaocheng Liu; Ningjun Li; Krishna M Boini; Pin-Lan Li
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-03-27       Impact factor: 3.000

Review 7.  Anti-inflammatory effects of omega 3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome.

Authors:  Esther Tortosa-Caparrós; Diana Navas-Carrillo; Francisco Marín; Esteban Orenes-Piñero
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8.  Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA).

Authors:  Robin E Duncan; Eszter Sarkadi-Nagy; Kathy Jaworski; Maryam Ahmadian; Hei Sook Sul
Journal:  J Biol Chem       Date:  2008-07-09       Impact factor: 5.157

9.  Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study.

Authors:  Marta Guasch-Ferré; Frank B Hu; Miguel Ruiz-Canela; Mònica Bulló; Estefanía Toledo; Dong D Wang; Dolores Corella; Enrique Gómez-Gracia; Miquel Fiol; Ramon Estruch; José Lapetra; Montserrat Fitó; Fernando Arós; Lluís Serra-Majem; Emilio Ros; Courtney Dennis; Liming Liang; Clary B Clish; Miguel A Martínez-González; Jordi Salas-Salvadó
Journal:  J Am Heart Assoc       Date:  2017-10-28       Impact factor: 5.501

10.  AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.

Authors:  Kathy Jaworski; Maryam Ahmadian; Robin E Duncan; Eszter Sarkadi-Nagy; Krista A Varady; Marc K Hellerstein; Hui-Young Lee; Varman T Samuel; Gerald I Shulman; Kee-Hong Kim; Sarah de Val; Chulho Kang; Hei Sook Sul
Journal:  Nat Med       Date:  2009-01-11       Impact factor: 53.440
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  2 in total

Review 1.  Metabolic Dysfunction in the Regulation of the NLRP3 Inflammasome Activation: A Potential Target for Diabetic Nephropathy.

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Journal:  J Diabetes Res       Date:  2022-06-09       Impact factor: 4.061

2.  Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed.

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Journal:  Front Immunol       Date:  2022-09-26       Impact factor: 8.786
  2 in total

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