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Literature DB >> 33643028

Autophagy as a Vital Therapy Target for Renal Cell Carcinoma.

Abstract

Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. Researchers have attempted to explore synthetic and phytochemical drugs for RCC therapy that target autophagy. In this review, we highlight the importance of autophagy in RCC and potential treatments related to autophagy.

Entities: CellLine Chemical Disease Gene Species

Keywords: AMPK/mTOR; PI3K/AKT/mTOR; autophagy; inducers; inhibitor; rcc

Year: 2021 PMID： 33643028 PMCID： PMC7902926 DOI： 10.3389/fphar.2020.518225

Source DB: PubMed Journal: Front Pharmacol ISSN： 1663-9812 Impact factor: 5.810

72 in total

Review 1. Epidemiology, Risk Assessment, and Biomarkers for Patients with Advanced Renal Cell Carcinoma.

Authors: Kyrollis Attalla; Stanley Weng; Martin H Voss; A Ari Hakimi
Journal: Urol Clin North Am Date: 2020-06-10 Impact factor: 2.241

2. Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1.

Authors: Satoshi Hirano; Takefumi Uemura; Hiromichi Annoh; Naonobu Fujita; Satoshi Waguri; Takashi Itoh; Mitsunori Fukuda
Journal: Autophagy Date: 2016 Impact factor: 16.016

3. Microenvironmental autophagy promotes tumour growth.

Authors: Nadja S Katheder; Rojyar Khezri; Fergal O'Farrell; Sebastian W Schultz; Ashish Jain; Mohammed M Rahman; Kay O Schink; Theodossis A Theodossiou; Terje Johansen; Gábor Juhász; David Bilder; Andreas Brech; Harald Stenmark; Tor Erik Rusten
Journal: Nature Date: 2017-01-11 Impact factor: 49.962

4. Expression pattern of autophagy-related markers in non-metastatic clear cell renal cell carcinoma: association with disease recurrence following radical nephrectomy.

Authors: Masatomo Nishikawa; Hideaki Miyake; Bing Liu; Masato Fujisawa
Journal: J Cancer Res Clin Oncol Date: 2015-02-01 Impact factor: 4.553

5. Autophagy is a major mechanism for the dual effects of curcumin on renal cell carcinoma cells.

Authors: Qian Deng; Liang Liang; Quanhai Liu; Wanli Duan; Yazhuo Jiang; Liandong Zhang
Journal: Eur J Pharmacol Date: 2018-03-01 Impact factor: 4.432

6. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Authors: Joungmok Kim; Mondira Kundu; Benoit Viollet; Kun-Liang Guan
Journal: Nat Cell Biol Date: 2011-01-23 Impact factor: 28.824

7. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.

Authors: X-D Liu; J Yao; D N Tripathi; Z Ding; Y Xu; M Sun; J Zhang; S Bai; P German; A Hoang; L Zhou; D Jonasch; X Zhang; C J Conti; E Efstathiou; N M Tannir; N T Eissa; G B Mills; C L Walker; E Jonasch
Journal: Oncogene Date: 2014-07-07 Impact factor: 9.867

8. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy.

Authors: J H Kang; J-S Lee; D Hong; S-H Lee; N Kim; W-K Lee; T-W Sung; Y-D Gong; S-Y Kim
Journal: Cell Death Dis Date: 2016-03-31 Impact factor: 8.469

9. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells.

Authors: Q Lu; S Yan; H Sun; W Wang; Y Li; X Yang; X Jiang; Y Che; Z Xi
Journal: Cell Death Dis Date: 2015-12-03 Impact factor: 8.469

10. Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.

Authors: Zhou Yu; Jing Ma; Xia Li; Yixiong Liu; Mingyang Li; Lu Wang; Ming Zhao; Huiying He; Yifen Zhang; Qiu Rao; Danhui Zhao; Yingmei Wang; Linni Fan; Peifeng Li; Yang Liu; Fang Liu; Feng Zhang; Jing Ye; Qingguo Yan; Shuangping Guo; Zhe Wang
Journal: Sci Rep Date: 2018-07-02 Impact factor: 4.379

2 in total

1. Overexpression of TP53INP2 Promotes Apoptosis in Clear Cell Renal Cell Cancer via Caspase-8/TRAF6 Signaling Pathway.

Authors: Xunjia Li; Daixing Hu; Ying Li; Yan Luo; Bing Liang; Kexiao Yu; Weijian Xiong; Deyu Zuo
Journal: J Immunol Res Date: 2022-05-14 Impact factor: 4.493

2. IFI35 Promotes Renal Cancer Progression by Inhibiting pSTAT1/pSTAT6-Dependent Autophagy.

Authors: Dafei Chai; Shang Yuchen Shi; Navid Sobhani; Jiage Ding; Zichun Zhang; Nan Jiang; Gang Wang; Minle Li; Hailong Li; Junnian Zheng; Jin Bai
Journal: Cancers (Basel) Date: 2022-06-09 Impact factor: 6.575

2 in total