| Literature DB >> 3364274 |
J Grote1, G Siegel, K Zimmer, A Adler.
Abstract
In vascular smooth muscle of canine carotid artery segments the decrease in oxygen tension from approximately 550 mmHg to approximately 30 mmHg leads to a dose-dependent hyperpolarization and relaxation of the vessel strip. At PO2 values below approximately 15-20 mmHg depolarization and subsequent contraction were found. All changes of the parameters investigated were reversible. Indomethacin (10(-5) M) had no significant effect on the hypoxia-dependent potential and tension changes. The hyperpolarized part of the activation curve was obtained by plotting tension versus membrane potential values.Entities:
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Year: 1988 PMID： 3364274 DOI： 10.1007/978-1-4615-9510-6_57
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622