Renata Robl Imoto1, Marjorie Uber2, Kerstin Taniguchi Abagge2, Mônica Nunes Lima3, Nelson Augusto Rosário4, Vânia Oliveira de Carvalho2. 1. Pediatric Dermatologist at Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil; natarobl@hotmail.com. 2. Pediatric Dermatologist at Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil. 3. Pediatrician at Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil. 4. Pediatric Allergist at Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil.
Abstract
BACKGROUND/ OBJECTIVES: There is evidence that vitamin D (VD) supplementation may help in the management of atopic dermatitis (AD). The aim of this study was to assess the influence of VD supplementation on the severity of AD. METHODS: Pre-post interventional study with prospective data collection in patients younger than 14 years. The severity of AD was determined through SCORAD (SCORing Atopic Dermatitis) and classified as mild (SCORAD < 25), moderate (≥25 and <50), and severe (≥50). Skin prick test was performed in all patients. Serum VD levels were classified as sufficient (≥30 ng/mL), insufficient (29 to 21 ng/mL), and deficient (≤20 ng/mL); and those with inadequate levels received oral supplementation of VD for 3 months, and were reassessed after treatment. RESULTS: A total of 152 patients were included. Patients with sufficient vitamin levels had lower SCORAD values (p = 0.04). Further, 116 patients (76.3%) received VD supplementation and after 3 months, VD levels were significantly higher (35.9 ng/mL) compared to baseline levels (23.7 ng/mL, p < 0.001). At the same time, a reduction in the SCORAD index was observed (19.4 before vs 12.3 after supplementation, p < 0.001). Considering other factors that could influence the decrease in AD severity after VD supplementation, female gender was associated with a worse treatment response (p = 0.02). CONCLUSION: Vitamin D supplementation could be an adjuvant in reducing the severity of atopic dermatitis.
BACKGROUND/ OBJECTIVES: There is evidence that vitamin D (VD) supplementation may help in the management of atopic dermatitis (AD). The aim of this study was to assess the influence of VD supplementation on the severity of AD. METHODS: Pre-post interventional study with prospective data collection in patients younger than 14 years. The severity of AD was determined through SCORAD (SCORing Atopic Dermatitis) and classified as mild (SCORAD < 25), moderate (≥25 and <50), and severe (≥50). Skin prick test was performed in all patients. Serum VD levels were classified as sufficient (≥30 ng/mL), insufficient (29 to 21 ng/mL), and deficient (≤20 ng/mL); and those with inadequate levels received oral supplementation of VD for 3 months, and were reassessed after treatment. RESULTS: A total of 152 patients were included. Patients with sufficient vitamin levels had lower SCORAD values (p = 0.04). Further, 116 patients (76.3%) received VD supplementation and after 3 months, VD levels were significantly higher (35.9 ng/mL) compared to baseline levels (23.7 ng/mL, p < 0.001). At the same time, a reduction in the SCORAD index was observed (19.4 before vs 12.3 after supplementation, p < 0.001). Considering other factors that could influence the decrease in AD severity after VD supplementation, female gender was associated with a worse treatment response (p = 0.02). CONCLUSION:Vitamin D supplementation could be an adjuvant in reducing the severity of atopic dermatitis.
Entities:
Keywords:
atopic dermatitis; skin prick test; vitamin D supplementation
Authors: Martin Alphonse; Shawn G Kwatra; Shilpa Gopinath; Nishadh Sutaria; Zachary A Bordeaux; Varsha Parthasarathy; Junwen Deng; Matthew T Taylor; Melika Marani; Kevin Lee; Thomas Pritchard; Ali Alajmi; Waleed Adawi; Olusola O Oladipo; Yevgeniy R Semenov Journal: Arch Dermatol Res Date: 2022-05-10 Impact factor: 3.017