| Literature DB >> 33639619 |
Natalie Lorenz1,2, Timothy K C Ho1, Reuben McGregor1,2, Mark R Davies3, Deborah A Williamson3, Jason K Gurney4, Pierre R Smeesters5, Michael G Baker2,4, Nicole J Moreland1,2.
Abstract
Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.Entities:
Keywords: zzm321990 emm-cluster; zzm321990 emm-type; group A Streptococcus; immune priming; rheumatic fever
Mesh:
Substances:
Year: 2021 PMID: 33639619 DOI: 10.1093/cid/ciab180
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079