Andrea Casadei-Gardini1,2, Toshifumi Tada3, Shigeo Shimose4, Takashi Kumada5, Takashi Niizeki4, Stefano Cascinu6,7, Alessandro Cucchetti8. 1. Università Vita-Salute, San Raffaele Hospital-IRCCS, via Olgettina 70, 20132, Milano, Italy. casadeigardini@gmail.com. 2. Department of Medical Oncology, San Raffaele Scientific Institute IRCCS, Milan, Italy. casadeigardini@gmail.com. 3. Department of Internal Medicine, Japanese Red Cross Society Himeji Hospital, Himeji, Japan. 4. Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, 830-0011, Japan. 5. Faculty of Nursing, Gifu Kyoritsu University, Ogaki, Japan. 6. Università Vita-Salute, San Raffaele Hospital-IRCCS, via Olgettina 70, 20132, Milano, Italy. 7. Department of Medical Oncology, San Raffaele Scientific Institute IRCCS, Milan, Italy. 8. Department of Medical and Surgical Sciences, DIMEC, Alma Mater Studiorum-University of Bologna, Bologna, Italy.
Abstract
BACKGROUND: Atezolizumab plus bevacizumab showed superior progression-free and overall survival compared to sorafenib in the IMbrave150 trial. It would therefore be useful to compare the efficacy of lenvatinib and that of atezolizumab plus bevacizumab to determine if a benefit of one therapy against the other exists. OBJECTIVE: The aim of the present report was to apply a matching-adjusted indirect comparison (MAIC) to individual participant data (IPD) from patients treated with lenvatinib outside of randomized trials, to aggregate results derived from the IMbrave150 trial. PATIENTS AND METHODS: Data from 455 patients who received lenvatinib as first-line systemic therapy for unresectable HCC represented the present IPD. Data inclusion were adapted to those reported in the IMbrave150 trial. RESULTS: Overall survival on atezolizumab plus bevacizumab proved to be superior to lenvatinib (log-rank: 0.001) with a hazard ratio of 0.59 (95% confidence interval 0.46-0.75). The number needed to treat ranged between seven in the first 12 months and five at the 15th month. CONCLUSIONS: The present MAIC highlights that the combination of atezolizumab plus bevacizumab is superior to lenvatinib. However, updated data or sub-analyses of the IMbrave150 trial would provide more robust estimates for such a treatment comparison.
BACKGROUND:Atezolizumab plus bevacizumab showed superior progression-free and overall survival compared to sorafenib in the IMbrave150 trial. It would therefore be useful to compare the efficacy of lenvatinib and that of atezolizumab plus bevacizumab to determine if a benefit of one therapy against the other exists. OBJECTIVE: The aim of the present report was to apply a matching-adjusted indirect comparison (MAIC) to individual participant data (IPD) from patients treated with lenvatinib outside of randomized trials, to aggregate results derived from the IMbrave150 trial. PATIENTS AND METHODS: Data from 455 patients who received lenvatinib as first-line systemic therapy for unresectable HCC represented the present IPD. Data inclusion were adapted to those reported in the IMbrave150 trial. RESULTS: Overall survival on atezolizumab plus bevacizumab proved to be superior to lenvatinib (log-rank: 0.001) with a hazard ratio of 0.59 (95% confidence interval 0.46-0.75). The number needed to treat ranged between seven in the first 12 months and five at the 15th month. CONCLUSIONS: The present MAIC highlights that the combination of atezolizumab plus bevacizumab is superior to lenvatinib. However, updated data or sub-analyses of the IMbrave150 trial would provide more robust estimates for such a treatment comparison.