Literature DB >> 336382

Prostacyclin (PGI2) is a weak contractor of coronary arteries of the pig.

G J Dusting, S Moncada, J R Vane.   

Abstract

The actions of prostacyclin (PGI2), prostaglandin E2 (PGE2), prostaglandin H2 (PGH2) and arachidonic acid have been examined on isolated coronary arteries from pigs. Arachidonate metabolites contracted this tissue, the order of potency being PGH2 greater than PGE2 greater than PGI2 suggesting that the coronary vasoconstrictor effects of PGH2 are limited by metabolism to PGI2. Sodium arachidonate and linoleate weakly relaxed porcine coronary arteries, but the former induced a secondary prolonged contraction: only the contraction was abolished by indomethacin. Thus the relaxation induced by fatty acids does not depend on metabolism to prostaglandin-like substances.

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Year:  1977        PMID： 336382     DOI： 10.1016/0014-2999(77)90014-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries.

Authors:  T Shoji; H Ishihara; T Ishikawa; A Saito; K Goto
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-10       Impact factor: 3.000

2.  Effects of isocarbacyclin, a stable prostacyclin analogue, on monkey isolated cerebral and peripheral arteries.

Authors:  Y Kawai; T Ohhashi
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739

3.  The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels.

Authors:  U Förstermann; G Hertting; B Neufang
Journal:  Br J Pharmacol       Date:  1984-04       Impact factor: 8.739

4.  Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with prostacyclin and other prostanoids.

Authors:  A L Hyman; P J Kadowitz; W E Lands; C G Crawford; J Fried; J Barton
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

5.  The calibre of cerebral arteries of the rat studied by carotid angiography: a model system for studying the aetiology of human cerebral arterial constriction after aneurysmal rupture.

Authors:  D J Boullin; V Aitken; G H du Boulay; P Tagari
Journal:  Neuroradiology       Date:  1981       Impact factor: 2.804

6.  The contractile mechanism of beraprost sodium, a stable prostacyclin analog, in the isolated canine femoral vein.

Authors:  M Ishikawa; A Namiki
Journal:  Heart Vessels       Date:  1994       Impact factor: 2.037

7.  Effects of prostacyclin (PGI2) and adenosine (ASN) on total and regional blood flow of isolated, collateralized dog hearts.

Authors:  J Scholtholt; H Birringer; V B Fiedler; B Schölkens
Journal:  Basic Res Cardiol       Date:  1981 May-Jun       Impact factor: 17.165

8.  Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice.

Authors:  Zhenhua Li; Yingzhan Zhang; Bin Liu; Wenhong Luo; Hui Li; Yingbi Zhou
Journal:  Sci Rep       Date:  2017-02-06       Impact factor: 4.379

9.  Increased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries.

Authors:  Bin Liu; Mengyi Zhan; Yingzhan Zhang; Hui Li; Xiangzhong Wu; Fengfeng Zhuang; Wenhong Luo; Yingbi Zhou
Journal:  Sci Rep       Date:  2017-08-21       Impact factor: 4.379

10.  EP3 Blockade Adds to the Effect of TP Deficiency in Alleviating Endothelial Dysfunction in Atherosclerotic Mouse Aortas.

Authors:  Chuangjia Hu; Bin Liu; Yineng Xu; Xiangzhong Wu; Tingting Guo; Yingzhan Zhang; Jing Leng; Jiahui Ge; Gang Yu; Jinwei Guo; Yingbi Zhou
Journal:  Front Physiol       Date:  2019-09-26       Impact factor: 4.566
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