Ying Chen1, Lijuan Wang2, Jie Zhang3, Sibo Wang4, Yajie Qi5, Jie Cao6, Yingqi Xing7. 1. Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: 187080119@163.com. 2. Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: wangljdr@163.com. 3. Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: ZhangJ_0106@163.com. 4. Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: wangsibo92@163.com. 5. Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: qi_yaj@163.com. 6. Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: caojie_lily@sina.com. 7. Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: xingyq2009@sina.com.
Abstract
OBJECTIVE: To explore whether quantitative electroencephalography (QEEG) and transcranial Doppler (TCD) can be used to evaluate patients with acute severe brainstem hemorrhage (ASBH). METHODS: We prospectively enrolled patients with ASBH and assessed their mortality at the 90-day follow-up. The patients' demographic data, serological data, and clinical factors were recorded. Quantitative brain function monitoring was performed using a TCD-QEEG recording system attached to the patient's bedside. RESULTS: Thirty-one patients (55.3 ± 10.6 years; 17 men) were studied. Mortality at 90 days was at 61.3%. There was no significant difference in TCD-related parameters between the survival group and the death group (p > 0.05). Among the QEEG-related indexes, only the (delta + theta)/(alpha + beta) ratio (DTABR) (odds ratio 11.555, 95%confidence interval 1.413-94.503, p = 0.022) was an independent predictor of clinical outcome; the area under the ROC curve of DTABR was 0.921, cut-off point was 3.88, sensitivity was 79%, and specificity was 100%. CONCLUSIONS: In patients with ASBH, QEEG can effectively inform the clinical prognosis regarding 90-day mortality, while TCD cannot. SIGNIFICANCE: QEEG shows promise for informing the mortality prognosis of patients with ASBH.
OBJECTIVE: To explore whether quantitative electroencephalography (QEEG) and transcranial Doppler (TCD) can be used to evaluate patients with acute severe brainstem hemorrhage (ASBH). METHODS: We prospectively enrolled patients with ASBH and assessed their mortality at the 90-day follow-up. The patients' demographic data, serological data, and clinical factors were recorded. Quantitative brain function monitoring was performed using a TCD-QEEG recording system attached to the patient's bedside. RESULTS: Thirty-one patients (55.3 ± 10.6 years; 17 men) were studied. Mortality at 90 days was at 61.3%. There was no significant difference in TCD-related parameters between the survival group and the death group (p > 0.05). Among the QEEG-related indexes, only the (delta + theta)/(alpha + beta) ratio (DTABR) (odds ratio 11.555, 95%confidence interval 1.413-94.503, p = 0.022) was an independent predictor of clinical outcome; the area under the ROC curve of DTABR was 0.921, cut-off point was 3.88, sensitivity was 79%, and specificity was 100%. CONCLUSIONS: In patients with ASBH, QEEG can effectively inform the clinical prognosis regarding 90-day mortality, while TCD cannot. SIGNIFICANCE: QEEG shows promise for informing the mortality prognosis of patients with ASBH.