Andrew S Fang1, Lee Jae Morse2, Rosanna Wustrack3, Ryan Huber4, Minggui Pan5. 1. Permanente Medicine, Department of Musculoskeletal Oncology, Kaiser South San Francisco, South San Francisco, CA. 2. Permanente Medicine, Department of Musculoskeletal Oncology, Kaiser Oakland, Oakland, CA. 3. Department of Orthopedics and Musculoskeletal Oncology, UCSF, San Francisco, CA. 4. Permanente Medicine, Department of Nuclear Medicine, Kaiser Santa Clara, Santa Clara, CA. 5. Permanente Medicine, Department of Hematology and Oncology, Kaiser Santa Clara, Santa Clara, CA.
Abstract
CASE PRESENTATION: A 33-year old man presented with a 25-cm lower extremity embryonal rhabdomyosarcoma with presumed extensive nodal metastasis on positron emission topography scan. Neoadjuvant chemotherapy and radiation provided minimal response. Following limb salvage resection and flap coverage, a prolonged postoperative infection occurred requiring intravenous antibiotics and wound care over 5 months. Given the infection, no postoperative radiation or chemotherapy was administered. Eight months following surgery, positron emission topography scan showed complete regression of local and nodal disease. The patient has remained in complete remission for more than 4 years. CONCLUSION: Postoperative wound infection leading to complete regression of embryonal rhabdomyosarcoma has not been reported. Stimulation of the innate and adaptive immune system through infectious elements is an area of ongoing immunotherapy research to improve sarcoma treatment outcomes.
CASE PRESENTATION: A 33-year old man presented with a 25-cm lower extremity embryonal rhabdomyosarcoma with presumed extensive nodal metastasis on positron emission topography scan. Neoadjuvant chemotherapy and radiation provided minimal response. Following limb salvage resection and flap coverage, a prolonged postoperative infection occurred requiring intravenous antibiotics and wound care over 5 months. Given the infection, no postoperative radiation or chemotherapy was administered. Eight months following surgery, positron emission topography scan showed complete regression of local and nodal disease. The patient has remained in complete remission for more than 4 years. CONCLUSION: Postoperative wound infection leading to complete regression of embryonal rhabdomyosarcoma has not been reported. Stimulation of the innate and adaptive immune system through infectious elements is an area of ongoing immunotherapy research to improve sarcoma treatment outcomes.
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