Literature DB >> 33635772

Case Report: Lactation Ketoacidosis Can Complicate the Ketogenic Diet.

Michelle C Liu1, Ruth Ann Bertsch1.   

Abstract

INTRODUCTION: Ketoacidosis is a metabolic condition caused by the buildup of ketone bodies. The most common causes are diabetes, alcoholism, and starvation. This is a case of a lactating mother on a ketogenic diet who developed a community-acquired pneumonia and then went into life-threatening ketoacidosis. CASE
PRESENTATION: A 32-year-old, lactating, 8-week-postpartum woman presented to the hospital complaining of nausea, vomiting, rhinorrhea, and cough. She had no history of diabetes or of alcohol or drug use but reported following a ketogenic diet and was found to have a pneumonia. The pneumonia was treated with antibiotics, and the acidosis resolved with a dextrose solution.
CONCLUSION: We report the case of a mother who, while lactating and losing weight on a ketogenic diet, developed a pneumonia and then went into ketoacidosis. Physicians should be aware that patients on the ketogenic diet are at risk for life-threatening acidosis, especially if they develop a second and/or third stressor or energy requirement on top of the low-carbohydrate diet. This case and those reviewed in the literature indicate that ketogenic diets may not be safe during lactation and could be associated with increased morbidity.
Copyright © 2021 The Permanente Press. All rights reserved.

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Year:  2021        PMID: 33635772      PMCID: PMC8784034          DOI: 10.7812/TPP/20.162

Source DB:  PubMed          Journal:  Perm J        ISSN: 1552-5767


  19 in total

Review 1.  Ketoacidosis - Where Do the Protons Come From?

Authors:  Allan Green; Ronald E Bishop
Journal:  Trends Biochem Sci       Date:  2019-02-08       Impact factor: 13.807

2.  Mechanisms to conserve glucose in lactating women during a 42-h fast.

Authors:  Mahmoud A Mohammad; Agneta L Sunehag; Shaji K Chacko; Amy S Pontius; Patricia D Maningat; Morey W Haymond
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-08-04       Impact factor: 4.310

3.  Ketosis and appetite-mediating nutrients and hormones after weight loss.

Authors:  P Sumithran; L A Prendergast; E Delbridge; K Purcell; A Shulkes; A Kriketos; J Proietto
Journal:  Eur J Clin Nutr       Date:  2013-05-01       Impact factor: 4.016

4.  Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects.

Authors:  Kieran Clarke; Kirill Tchabanenko; Robert Pawlosky; Emma Carter; M Todd King; Kathy Musa-Veloso; Manki Ho; Ashley Roberts; Jeremy Robertson; Theodore B Vanitallie; Richard L Veech
Journal:  Regul Toxicol Pharmacol       Date:  2012-05-03       Impact factor: 3.271

5.  Complications of the ketogenic diet.

Authors:  K Ballaban-Gil; C Callahan; C O'Dell; M Pappo; S Moshé; S Shinnar
Journal:  Epilepsia       Date:  1998-07       Impact factor: 5.864

Review 6.  Starvation ketoacidosis in pregnancy.

Authors:  Charlotte J Frise; Lucy Mackillop; Karen Joash; Catherine Williamson
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2012-11-04       Impact factor: 2.435

Review 7.  Ketone body production and disposal: effects of fasting, diabetes, and exercise.

Authors:  E O Balasse; F Féry
Journal:  Diabetes Metab Rev       Date:  1989-05

8.  Life-Threatening Lactation or "Bovine" Ketoacidosis: A Case Report.

Authors:  David J Greaney; Pat Benson
Journal:  A A Case Rep       Date:  2016-08-15

9.  Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman: a case report.

Authors:  Louise von Geijer; Magnus Ekelund
Journal:  J Med Case Rep       Date:  2015-10-01

10.  Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.

Authors:  Aya Kamba; Makoto Daimon; Hiroshi Murakami; Hideyuki Otaka; Kota Matsuki; Eri Sato; Jutaro Tanabe; Shinobu Takayasu; Yuki Matsuhashi; Miyuki Yanagimachi; Ken Terui; Kazunori Kageyama; Itoyo Tokuda; Ippei Takahashi; Shigeyuki Nakaji
Journal:  PLoS One       Date:  2016-11-18       Impact factor: 3.240

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