Literature DB >> 33635423

Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism.

Simge Aykan1, Meghan H Puglia2,3, Canan Kalaycıoğlu4, Kevin A Pelphrey2, Timur Tuncalı5, Erhan Nalçacı4.   

Abstract

Our aim was to use theta coherence as a quantitative trait to investigate the relation of the polymorphisms in NKCC1 (rs3087889) and KCC2 (rs9074) channel protein genes to autistic traits (AQ) in neurotypicals. Coherence values for candidate connection regions were calculated from eyes-closed resting EEGs in two independent groups. Hypersynchrony within the right anterior region was related to AQ in both groups (p < 0.05), and variability in this hypersynchrony was related to the rs9074 polymorphism in the total group (p < 0.05). In conclusion, theta hypersynchrony within the right anterior region during eyes-closed rest can be considered a quantitative measure for autistic traits. Replicating our findings in two independent populations with different backgrounds strengthens the validity of the current study.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Entities:  

Keywords:  Autistic traits; Coherence; Excitation/inhibition imbalance; KCC2; Quantitative traits; Theta oscillations

Mesh：

Substances：

Year:  2021        PMID： 33635423     DOI： 10.1007/s10803-021-04924-x

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


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