Yunpeng Bai1,2, Wendong Huang1,3, Yaocai Li4, Changchun Lai5, Sumei Huang1,6, Guangwen Wang1, Yuemei He1, Linhui Hu1,2, Chunbo Chen1,2. 1. Center of Scientific Research, Maoming People's Hospital, Maoming 525000, China. 2. Department of Critical Care Medicine, Maoming People's Hospital, Maoming 525000, China. 3. Department of Cardiology, Maoming People's Hospital, Maoming 525000, China. 4. Department of Infectious Diseases, Maoming People's Hospital, Maoming 525000, China. 5. Department of Clinical Laboratory, Maoming People's Hospital, Maoming 525000, China. 6. Biological Resource Center of Maoming People's Hospital, Maoming 525000, China.
Abstract
BACKGROUND: The pandemic of novel coronavirus disease 2019 (COVID-19) has become a serious public health crisis worldwide. The symptoms of COVID-19 vary from mild to severe among different age groups, but the physiological changes related to COVID-19 are barely understood. METHODS: In the present study, a high-resolution mass spectrometry (HRMS)-based lipidomic strategy was used to characterize the endogenous plasma lipids for cured COVID-19 patients with different ages and symptoms. These patients were further divided into two groups: those with severe symptoms or who were elderly and relatively young patients with mild symptoms. In addition, automated lipidomic identification and alignment was conducted by LipidSearch software. Multivariate and univariate analyses were used for differential comparison. RESULTS: Nearly 500 lipid compounds were identified in each cured COVID-19 group through LipidSearch software. At the level of lipid subclasses, patients with severe symptoms or elderly patients displayed dramatic changes in plasma lipidomic alterations, such as increased triglycerides and decreased cholesteryl esters (ChE). Some of these differential lipids might also have essential biological functions. Furthermore, the differential analysis of plasma lipids among groups was performed to provide potential prognostic indicators, and the change in signaling pathways. CONCLUSIONS: Dyslipidemia was observed in cured COVID-19 patients due to the viral infection and medical treatment, and the discharged patients should continue to undergo consolidation therapy. This work provides valuable knowledge about plasma lipid markers and potential therapeutic targets of COVID-19 and essential resources for further research on the pathogenesis of COVID-19.
BACKGROUND: The pandemic of novel coronavirus disease 2019 (COVID-19) has become a serious public health crisis worldwide. The symptoms of COVID-19 vary from mild to severe among different age groups, but the physiological changes related to COVID-19 are barely understood. METHODS: In the present study, a high-resolution mass spectrometry (HRMS)-based lipidomic strategy was used to characterize the endogenous plasma lipids for cured COVID-19patients with different ages and symptoms. These patients were further divided into two groups: those with severe symptoms or who were elderly and relatively young patients with mild symptoms. In addition, automated lipidomic identification and alignment was conducted by LipidSearch software. Multivariate and univariate analyses were used for differential comparison. RESULTS: Nearly 500 lipid compounds were identified in each cured COVID-19 group through LipidSearch software. At the level of lipid subclasses, patients with severe symptoms or elderly patients displayed dramatic changes in plasma lipidomic alterations, such as increased triglycerides and decreased cholesteryl esters (ChE). Some of these differential lipids might also have essential biological functions. Furthermore, the differential analysis of plasma lipids among groups was performed to provide potential prognostic indicators, and the change in signaling pathways. CONCLUSIONS:Dyslipidemia was observed in cured COVID-19patients due to the viral infection and medical treatment, and the discharged patients should continue to undergo consolidation therapy. This work provides valuable knowledge about plasma lipid markers and potential therapeutic targets of COVID-19 and essential resources for further research on the pathogenesis of COVID-19.
Authors: Luana Xavier Soares Gomes Moura Fé; Eliane Pereira Cipolatti; Martina Costa Cerqueira Pinto; Suema Branco; Fábio César Sousa Nogueira; Gisela Maria Dellamora Ortiz; Anderson de Sá Pinheiro; Evelin Andrade Manoel Journal: Med Res Rev Date: 2022-06-28 Impact factor: 12.388
Authors: Céline Occelli; Jean-Marie Guigonis; Sabine Lindenthal; Alexandre Cagnard; Fanny Graslin; Vesna Brglez; Barbara Seitz-Polski; Jean Dellamonica; Jacques Levraut; Thierry Pourcher Journal: Front Med (Lausanne) Date: 2022-09-29