Literature DB >> 33635001

Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.

Satish Sagar1, Ashok Kumar Rathinavel1, William E Lutz1, Lucas R Struble1, Surender Khurana2, Andy T Schnaubelt3, Nitish Kumar Mishra4, Chittibabu Guda4,5, Nicholas Y Palermo6, Mara J Broadhurst3, Tobias Hoffmann7, Kenneth W Bayles3, St Patrick M Reid3, Gloria E O Borgstahl1,5, Prakash Radhakrishnan1,3,4,5.   

Abstract

Entities:  

Year:  2021        PMID： 33635001      PMCID： PMC7811777          DOI： 10.1002/ctm2.281

Source DB:  PubMed          Journal:  Clin Transl Med        ISSN： 2001-1326


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  9 in total

1.  Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System.

Authors:  Seda Bilaloglu; Yin Aphinyanaphongs; Simon Jones; Eduardo Iturrate; Judith Hochman; Jeffrey S Berger
Journal:  JAMA       Date:  2020-08-25       Impact factor: 56.272

2.  Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients.

Authors:  G E Felton
Journal:  Med Hypotheses       Date:  1980-11       Impact factor: 1.538

3.  Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial.

Authors:  Omer Waleed Majid; Bashar Adil Al-Mashhadani
Journal:  J Oral Maxillofac Surg       Date:  2014-01-16       Impact factor: 1.895

4.  Discovering drugs to treat coronavirus disease 2019 (COVID-19).

Authors:  Liying Dong; Shasha Hu; Jianjun Gao
Journal:  Drug Discov Ther       Date:  2020

5.  A novel treatment of bromelain and acetylcysteine (BromAc) in patients with peritoneal mucinous tumours: A phase I first in man study.

Authors:  S J Valle; J Akhter; A H Mekkawy; S Lodh; K Pillai; S Badar; D Glenn; M Power; W Liauw; D L Morris
Journal:  Eur J Surg Oncol       Date:  2019-10-31       Impact factor: 4.424

Review 6.  COVID-19 and Multiorgan Response.

Authors:  Sevim Zaim; Jun Heng Chong; Vissagan Sankaranarayanan; Amer Harky
Journal:  Curr Probl Cardiol       Date:  2020-04-28       Impact factor: 5.200

Review 7.  Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status.

Authors:  Tarek Mohamed Abd El-Aziz; James D Stockand
Journal:  Infect Genet Evol       Date:  2020-04-19       Impact factor: 3.342

8.  SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Authors:  Markus Hoffmann; Hannah Kleine-Weber; Simon Schroeder; Nadine Krüger; Tanja Herrler; Sandra Erichsen; Tobias S Schiergens; Georg Herrler; Nai-Huei Wu; Andreas Nitsche; Marcel A Müller; Christian Drosten; Stefan Pöhlmann
Journal:  Cell       Date:  2020-03-05       Impact factor: 41.582

9.  ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.

Authors:  Paul Towler; Bart Staker; Sridhar G Prasad; Saurabh Menon; Jin Tang; Thomas Parsons; Dominic Ryan; Martin Fisher; David Williams; Natalie A Dales; Michael A Patane; Michael W Pantoliano
Journal:  J Biol Chem       Date:  2004-01-30       Impact factor: 5.157
  9 in total
  6 in total

1.  Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding.

Authors:  Lucas R Struble; Audrey L Smith; William E Lutz; Gabrielle Grubbs; Satish Sagar; Kenneth W Bayles; Prakash Radhakrishnan; Surender Khurana; Dalia El-Gamal; Gloria E O Borgstahl
Journal:  Protein Sci       Date:  2022-05       Impact factor: 6.725

Review 2.  Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19.

Authors:  Matteo Tosato; Francesca Ciciarello; Maria Beatrice Zazzara; Cristina Pais; Giulia Savera; Anna Picca; Vincenzo Galluzzo; Hélio José Coelho-Júnior; Riccardo Calvani; Emanuele Marzetti; Francesco Landi
Journal:  Clin Geriatr Med       Date:  2022-06-20       Impact factor: 3.529

Review 3.  The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.

Authors:  Douglas B Kell; Etheresia Pretorius
Journal:  Biochem J       Date:  2022-08-31       Impact factor: 3.766

4.  The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2.

Authors:  Javed Akhter; Grégory Quéromès; Krishna Pillai; Vahan Kepenekian; Samina Badar; Ahmed H Mekkawy; Emilie Frobert; Sarah J Valle; David L Morris
Journal:  Viruses       Date:  2021-03-06       Impact factor: 5.048

Review 5.  Beneficial Properties of Bromelain.

Authors:  Pawel Hikisz; Joanna Bernasinska-Slomczewska
Journal:  Nutrients       Date:  2021-11-29       Impact factor: 5.717

6.  Garcinia kola and garcinoic acid suppress SARS-CoV-2 spike glycoprotein S1-induced hyper-inflammation in human PBMCs through inhibition of NF-κB activation.

Authors:  Olumayokun A Olajide; Victoria U Iwuanyanwu; Izabela Lepiarz-Raba; Alaa A Al-Hindawi; Mutalib A Aderogba; Hazel L Sharp; Robert J Nash
Journal:  Phytother Res       Date:  2021-10-26       Impact factor: 6.388
  6 in total

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