| Literature DB >> 33634033 |
Daphne A J J Driessen1, Tim Dijkema1, Willem L J Weijs2, Robert P Takes3, Sjoert A H Pegge4, Patrik Zámecnik4, Adriana C H van Engen-van Grunsven5, Tom W J Scheenen4, Johannes H A M Kaanders1.
Abstract
In head and neck cancer, the presence of nodal disease is a strong determinant of prognosis and treatment. Despite the use of modern multimodality diagnostic imaging, the prevalence of occult nodal metastases is relatively high. This is why in clinically node negative head and neck cancer the lymphatics are treated "electively" to eradicate subclinical tumor deposits. As a consequence, many true node negative patients undergo surgery or irradiation of the neck and suffer from the associated and unnecessary early and long-term morbidity. Safely tailoring head and neck cancer treatment to individual patients requires a more accurate pre-treatment assessment of nodal status. In this review, we discuss the potential of several innovative diagnostic approaches to guide customized management of the clinically negative neck in head and neck cancer patients.Entities:
Keywords: FDG-PET/CT; elective neck treatment; head and neck cancer; lymph node metastases; nanoparticles enhanced MRI; nodal staging; sentinel lymph node identification
Year: 2021 PMID： 33634033 PMCID： PMC7901951 DOI： 10.3389/fonc.2020.637513
Source DB: PubMed Journal: Front Oncol ISSN： 2234-943X Impact factor: 6.244