| Literature DB >> 33633167 |
Geovani de Oliveira Ribeiro1, Antonio Charlys da Costa2, Danielle Elise Gill3, Edcelha Soares D'Athaide Ribeiro4, Marlisson Octavio da S Rego4, Fred Julio Costa Monteiro4, Fabiola Villanova1, Juliana Silva Nogueira5, Adriana Yurika Maeda5, Renato Pereira de Souza5, Roozbeh Tahmasebi3, Vanessa S Morais3, Ramendra Pati Pandey6, V Samuel Raj6, Sirle Abdo Salloum Scandar7, Fernanda Gisele da Silva Vasami5, Leandro Guaraglia D'Agostino5, Paulo César Maiorka8, Xutao Deng9,10, Maurício Lacerda Nogueira11, Ester Cerdeira Sabino3, Eric Delwart12,13, Élcio Leal14, Mariana Sequetin Cunha15,16.
Abstract
Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative dISFV, termed Guapiaçu virus (GUAPV). Distinct strains of GUAPV were isolated from pools of Aedes terrens and Aedes scapularis mosquitoes. Additionally, we also detected viral GUAPV RNA in a plasma sample of an individual febrile from the Amazon region (North of Brazil). Although GUAPV did not replicate in tested mammalian cells, 3'UTR secondary structures duplication and codon usage index were similar to pathogenic flavivirus.Entities:
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Year: 2021 PMID： 33633167 PMCID： PMC7907106 DOI： 10.1038/s41598-021-83879-6
Source DB: PubMed Journal: Sci Rep ISSN： 2045-2322 Impact factor: 4.379