Yaohao Wu1, Lexiang Zeng1, Ronglin Qiu1, Jie Zhang1, Jianhang Su1, Minyi Liao1, Xiaogeng Deng2. 1. Department of Pediatric Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 2. Department of Pediatric Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. dengxg@mail.sysu.edu.cn.
Abstract
PURPOSE: Laparoscopic resection of giant hepatoblastoma (HB) in children has long been a subject of controversy. Here, a new procedure of two-stage laparoscopic resection of giant HB in infants was firstly reported and the feasibility was discussed. METHODS: The clinical data of three infants with HB were retrospectively reviewed, all of which received 3-5 cycles of neoadjuvant chemotherapy. Stage 1 laparoscopic selective hepatic artery ligation and liver partial partition were performed. Stage 2 laparoscopic hepatectomy was performed 2 weeks later. RESULTS: The results demonstrated that (1) the tumors shrank considerably in size and had relatively clear boundaries after neoadjuvant chemotherapy; (2) after stage 1 surgery, the tumor volume further reduced, while the intratumoral necrosis expanded; (3) 2 weeks later, stage 2 laparoscopic hepatectomy was performed successfully; (4) none of the cases had intraoperative complications such as tumor rupture, air embolism, hemorrhage, biliary fistula, or liver failure, and there was no recurrence or metastasis during follow-up. CONCLUSIONS: Two-stage laparoscopic hepatectomy associating selective hepatic artery ligation and liver partial partition for HB in infants has the benefits of small invasiveness, fast recovery, improved safety, and high feasibility. However, more cases and longer follow-up are needed to assess its long-term efficacy.
PURPOSE: Laparoscopic resection of giant hepatoblastoma (HB) in children has long been a subject of controversy. Here, a new procedure of two-stage laparoscopic resection of giant HB in infants was firstly reported and the feasibility was discussed. METHODS: The clinical data of three infants with HB were retrospectively reviewed, all of which received 3-5 cycles of neoadjuvant chemotherapy. Stage 1 laparoscopic selective hepatic artery ligation and liver partial partition were performed. Stage 2 laparoscopic hepatectomy was performed 2 weeks later. RESULTS: The results demonstrated that (1) the tumors shrank considerably in size and had relatively clear boundaries after neoadjuvant chemotherapy; (2) after stage 1 surgery, the tumor volume further reduced, while the intratumoral necrosis expanded; (3) 2 weeks later, stage 2 laparoscopic hepatectomy was performed successfully; (4) none of the cases had intraoperative complications such as tumor rupture, air embolism, hemorrhage, biliary fistula, or liver failure, and there was no recurrence or metastasis during follow-up. CONCLUSIONS: Two-stage laparoscopic hepatectomy associating selective hepatic artery ligation and liver partial partition for HB in infants has the benefits of small invasiveness, fast recovery, improved safety, and high feasibility. However, more cases and longer follow-up are needed to assess its long-term efficacy.
Entities:
Keywords:
Hepatoblastoma; Infant; Laparoscopy; Staged surgery
Authors: J Brown; G Perilongo; E Shafford; J Keeling; J Pritchard; P Brock; C Dicks-Mireaux; A Phillips; A Vos; J Plaschkes Journal: Eur J Cancer Date: 2000-07 Impact factor: 9.162
Authors: Katarzyna B Hooks; Jérôme Audoux; Helena Fazli; Sarah Lesjean; Tony Ernault; Nathalie Dugot-Senant; Thierry Leste-Lasserre; Martin Hagedorn; Benoit Rousseau; Coralie Danet; Sophie Branchereau; Laurence Brugières; Sophie Taque; Catherine Guettier; Monique Fabre; Anne Rullier; Marie-Annick Buendia; Thérèse Commes; Christophe F Grosset; Anne-Aurélie Raymond Journal: Hepatology Date: 2018-05-14 Impact factor: 17.425