Literature DB >> 33632165

Initiation of hepatitis C treatment in two rural Rwandan districts: a mobile clinic approach.

Innocent Kamali1, Dale A Barnhart2,3, Françoise Nyirahabihirwe2, Jean de la Paix Gakuru2, Mariam Uwase2, Esdras Nizeyumuremyi2, Stephen Walker4, Christian Mazimpaka2, Jean de Dieu Gatete2, Jean Damascene Makuza5,6, Janvier Serumondo5, Fredrick Kateera2, Jean d'Amour Ndahimana2.   

Abstract

BACKGROUND: To eliminate hepatitis C, Rwanda is conducting national mass screenings and providing to people with chronic hepatitis C free access to Direct Acting Antivirals (DAAs). Until 2020, prescribers trained and authorized to initiate DAA treatment were based at district hospitals, and access to DAAs remains expensive and geographically difficult for rural patients. We implemented a mobile clinic to provide DAA treatment initiation at primary-level health facilities among people with chronic hepatitis C identified through mass screening campaigns in rural Kirehe and Kayonza districts.
METHODS: The mobile clinic team was composed of one clinician authorized to manage hepatitis, one lab technician, and one driver. Eligible patients received same-day clinical consultations, counselling, laboratory tests and DAA initiation. Using clinical databases, registers, and program records, we compared the number of patients who initiated DAA treatment before and during the mobile clinic campaign. We assessed linkage to care during the mobile clinical campaign and assessed predictors of linkage to care. We also estimated the cost per patient of providing mobile services and the reduction in out-of-pocket costs associated with accessing DAA treatment through the mobile clinic rather than the standard of care.
RESULTS: Prior to the mobile clinic, only 408 patients in Kirehe and Kayonza had been initiated on DAAs over a 25-month period. Between November 2019 and January 2020, out of 661 eligible patients with hepatitis C, 429 (64.9%) were linked to care through the mobile clinic. Having a telephone number and complete address recorded at screening were strongly associated with linkage to care. The cost per patient of the mobile clinic program was 29.36 USD, excluding government-provided DAAs. Providing patients with same-day laboratory tests and clinical consultation at primary-level health facilities reduced out-of-pocket expenses by 9.88 USD.
CONCLUSION: The mobile clinic was a feasible strategy for providing rapid treatment initiation among people chronically infected by hepatitis C, identified through a mass screening campaign. Compared to the standard of care, mobile clinics reached more patients in a much shorter time. This low-cost strategy also reduced out-of-pocket expenditures among patients. However, long-term, sustainable care would require decentralization to the primary health-centre level.

Entities:  

Keywords:  Hepatitis C; Mobile clinic; Rural health; Rwanda

Mesh:

Substances:

Year:  2021        PMID: 33632165      PMCID: PMC7908655          DOI: 10.1186/s12879-021-05920-3

Source DB:  PubMed          Journal:  BMC Infect Dis        ISSN: 1471-2334            Impact factor:   3.090


  20 in total

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Authors:  Grace Umutesi; Fabienne Shumbusho; Fredrick Kateera; Janvier Serumondo; Jules Kabahizi; Emmanuel Musabeyezu; Alida Ngwije; Neil Gupta; Sabin Nsanzimana
Journal:  J Hepatol       Date:  2019-04-01       Impact factor: 25.083

2.  Effectiveness of Direct-Acting Antivirals for the treatment of chronic hepatitis C in Rwanda: A retrospective study.

Authors:  Sabin Nsanzimana; Michael J Penkunas; Carol Y Liu; Dieudonne Sebuhoro; Alida Ngwije; Eric Remera; Justine Umutesi; Cyprien Ntirenganya; Soline D Mugeni; Janvier Serumondo
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4.  Multi-country analysis of treatment costs for HIV/AIDS (MATCH): facility-level ART unit cost analysis in Ethiopia, Malawi, Rwanda, South Africa and Zambia.

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Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240

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7.  Screening a nation for hepatitis C virus elimination: a cross-sectional study on prevalence of hepatitis C and associated risk factors in the Rwandan general population.

Authors:  Justine Umutesi; Carol Yingkai Liu; Michael J Penkunas; Jean Damascene Makuza; Corneille K Ntihabose; Sabine Umuraza; Julienne Niyikora; Janvier Serumondo; Neil Gupta; Sabin Nsanzimana
Journal:  BMJ Open       Date:  2019-07-03       Impact factor: 2.692

8.  Real life efficacy and safety of direct-acting antiviral therapy for treatment of patients infected with hepatitis C virus genotypes 1, 2 and 3 in northwest China.

Authors:  Ying Yang; Feng-Ping Wu; Wen-Jun Wang; Juan-Juan Shi; Ya-Ping Li; Xin Zhang; Shuang-Suo Dang
Journal:  World J Gastroenterol       Date:  2019-11-28       Impact factor: 5.742

9.  Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis.

Authors:  Ali A Mokdad; Alan D Lopez; Saied Shahraz; Rafael Lozano; Ali H Mokdad; Jeff Stanaway; Christopher J L Murray; Mohsen Naghavi
Journal:  BMC Med       Date:  2014-09-18       Impact factor: 8.775

10.  Effectiveness of direct-acting antiviral therapy for hepatitis C in difficult-to-treat patients in a safety-net health system: a retrospective cohort study.

Authors:  Christina Yek; Carolina de la Flor; John Marshall; Cindy Zoellner; Grace Thompson; Lisa Quirk; Christian Mayorga; Barbara J Turner; Amit G Singal; Mamta K Jain
Journal:  BMC Med       Date:  2017-11-20       Impact factor: 8.775

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