Luc Djousse1, Mary L Biggs2, Nirupa R Matthan3, Joachim H Ix4, Annette L Fitzpatrick2, Irena King5, Rozenn N Lemaitre2, Barbara McKnight6, Jorge R Kizer7, Alice H Lichtenstein3, Kenneth J Mukamal8, David S Siscovick9. 1. Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA, ldjousse@rics.bwh.harvard.edu. 2. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. 3. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA. 4. Division of Nephrology, Department of Medicine, University of California, San Diego, California, USA. 5. Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA. 6. Department of Biostatistics, University of Washington, Seattle, Washington, USA. 7. San Francisco VA Health Care System and University of California, San Francisco, California, USA. 8. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. 9. New York Academy of Medicine, New York, New York, USA.
Abstract
BACKGROUND: Heart failure (HF) is highly prevalent among older adults and is associated with high costs. Although serum total nonesterified fatty acids (NEFAs) have been positively associated with HF risk, the contribution of each individual NEFA to HF risk has not been examined. OBJECTIVE: The aim of this study was to examine the association of individual fasting NEFAs with HF risk in older adults. METHODS: In this prospective cohort study of older adults, we measured 35 individual NEFAs in 2,140 participants of the Cardiovascular Health Study using gas chromatography. HF was ascertained using review of medical records by an endpoint committee. RESULTS: The mean age was 77.7 ± 4.4 years, and 38.8% were male. During a median follow-up of 9.7 (maximum 19.0) years, 655 new cases of HF occurred. In a multivariable Cox regression model controlling for demographic and anthropometric variables, field center, education, serum albumin, glomerular filtration rate, physical activity, alcohol consumption, smoking, hormone replacement therapy, unintentional weight loss, and all other measured NEFAs, we observed inverse associations (HR [95% CI] per standard deviation) of nonesterified pentadecanoic (15:0) (0.73 [0.57-0.94]), γ-linolenic acid (GLA) (0.87 [0.75-1.00]), and docosahexaenoic acid (DHA) (0.73 [0.61-0.88]) acids with HF, and positive associations of nonesterified stearic (18:0) (1.30 [1.04-1.63]) and nervonic (24:1n-9) (1.17 [1.06-1.29]) acids with HF. CONCLUSION: Our data are consistent with a higher risk of HF with nonesterified stearic and nervonic acids and a lower risk with nonesterified 15:0, GLA, and DHA in older adults. If confirmed in other studies, specific NEFAs may provide new targets for HF prevention.
BACKGROUND: Heart failure (HF) is highly prevalent among older adults and is associated with high costs. Although serum total nonesterified fatty acids (NEFAs) have been positively associated with HF risk, the contribution of each individual NEFA to HF risk has not been examined. OBJECTIVE: The aim of this study was to examine the association of individual fasting NEFAs with HF risk in older adults. METHODS: In this prospective cohort study of older adults, we measured 35 individual NEFAs in 2,140 participants of the Cardiovascular Health Study using gas chromatography. HF was ascertained using review of medical records by an endpoint committee. RESULTS: The mean age was 77.7 ± 4.4 years, and 38.8% were male. During a median follow-up of 9.7 (maximum 19.0) years, 655 new cases of HF occurred. In a multivariable Cox regression model controlling for demographic and anthropometric variables, field center, education, serum albumin, glomerular filtration rate, physical activity, alcohol consumption, smoking, hormone replacement therapy, unintentional weight loss, and all other measured NEFAs, we observed inverse associations (HR [95% CI] per standard deviation) of nonesterified pentadecanoic (15:0) (0.73 [0.57-0.94]), γ-linolenic acid (GLA) (0.87 [0.75-1.00]), and docosahexaenoic acid (DHA) (0.73 [0.61-0.88]) acids with HF, and positive associations of nonesterified stearic (18:0) (1.30 [1.04-1.63]) and nervonic (24:1n-9) (1.17 [1.06-1.29]) acids with HF. CONCLUSION: Our data are consistent with a higher risk of HF with nonesterified stearic and nervonic acids and a lower risk with nonesterified 15:0, GLA, and DHA in older adults. If confirmed in other studies, specific NEFAs may provide new targets for HF prevention.
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Authors: Luc Djoussé; Owais Khawaja; Traci M Bartz; Mary L Biggs; Joachim H Ix; Susan J Zieman; Jorge R Kizer; Russell P Tracy; David S Siscovick; Kenneth J Mukamal Journal: Diabetes Care Date: 2012-05-14 Impact factor: 19.112
Authors: Rozenn N Lemaitre; Barbara McKnight; Nona Sotoodehnia; Amanda M Fretts; Waqas T Qureshi; Xiaoling Song; Irena B King; Colleen M Sitlani; David S Siscovick; Bruce M Psaty; Dariush Mozaffarian Journal: J Am Heart Assoc Date: 2018-11-06 Impact factor: 5.501