BACKGROUND/AIMS: This retrospective study aimed to evaluate the effect of low-dose aspirin (50-150 mg/d) on the severity of ischemic colitis. MATERIALS AND METHODS: A total of 244 patients admitted to our hospital for ischemic colitis between 2013 and 2018 were included in the study. Patients were divided into two groups-aspirin and non-aspirin groups-based on their recent history of aspirin use before the onset of ischemic colitis. Clinical performance, biochemical indices, and endoscopic findings were compared. RESULTS: The average age and the proportion of underlying disease, including hypertension, cerebral infarction, and coronary heart disease in the aspirin group was significantly higher than those in the non-aspirin group (p<0.05). In terms of clinical symptoms, the proportion of diarrhea in the aspirin group was significantly higher than that in the non-aspirin group, while the proportion of abdominal pain was significantly lower in the aspirin group compared with the non-aspirin group. Colonoscopy results showed that the incidence of ulceration was significantly higher in the aspirin group than in the non-aspirin group (p<0.05). CONCLUSION: The use of low-dose aspirin may aggravate the severity and mask the symptoms of abdominal pain in ischemic colitis.
BACKGROUND/AIMS: This retrospective study aimed to evaluate the effect of low-dose aspirin (50-150 mg/d) on the severity of ischemic colitis. MATERIALS AND METHODS: A total of 244 patients admitted to our hospital for ischemic colitis between 2013 and 2018 were included in the study. Patients were divided into two groups-aspirin and non-aspirin groups-based on their recent history of aspirin use before the onset of ischemic colitis. Clinical performance, biochemical indices, and endoscopic findings were compared. RESULTS: The average age and the proportion of underlying disease, including hypertension, cerebral infarction, and coronary heart disease in the aspirin group was significantly higher than those in the non-aspirin group (p<0.05). In terms of clinical symptoms, the proportion of diarrhea in the aspirin group was significantly higher than that in the non-aspirin group, while the proportion of abdominal pain was significantly lower in the aspirin group compared with the non-aspirin group. Colonoscopy results showed that the incidence of ulceration was significantly higher in the aspirin group than in the non-aspirin group (p<0.05). CONCLUSION: The use of low-dose aspirin may aggravate the severity and mask the symptoms of abdominal pain in ischemic colitis.
Authors: Matthew D Sadler; Nikila C Ravindran; James Hubbard; Robert P Myers; Subrata Ghosh; Paul L Beck; Elijah Dixon; Chad Ball; Chris Prusinkiewicz; Steven J Heitman; Gilaad G Kaplan Journal: Can J Gastroenterol Hepatol Date: 2014-12
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Authors: Jussi M Kärkkäinen; Petri Saari; Hannu-Pekka Kettunen; Tiina T Lehtimäki; Ritva Vanninen; Hannu Paajanen; Hannu Manninen Journal: J Gastrointest Surg Date: 2015-11-09 Impact factor: 3.452
Authors: Modinat A Adefisayo; Rufus O Akomolafe; Olumide S Akinsomisoye; Quadri K Alabi; Laofe Ogundipe; Joseph G Omole; Kehinde P Olamilosoye Journal: Dose Response Date: 2018-07-08 Impact factor: 2.658