Effects of heterotopic ischemic pain on muscular pain threshold and blink reflex in humans.

Ischemic pain was induced in the left arm of 6 healthy volunteers using a modification of the submaximal effort tourniquet test. Its effects on both muscular pain threshold (determined in the vastus medialis muscle by means of electrical stimulation) and on the 2nd component of the blink reflex (R2) were investigated in the contralateral body side. Muscular pain threshold increased (peak value during ischemic pain) and maintained significantly higher values for 60 min. R2 response decreased while its latency increased; these variations appeared during ischemic pain and reached a maximum soon after the end of ischemia, still remaining significant for 15 min. The results support the suggestion that the analgesic effects of heterotopic noxious stimulation in humans are subserved by supraspinal inhibitory mechanisms.