Literature DB >> 33623561

Immunity, parasites, genetics and sex hormones: contributors to mild inflammatory responses in COVID-19?

Samuel Munalula Munjita1,2, Mulemba Samutela1,3, Kunda Ndashe4, Sody Mweetwa Munsaka1.   

Abstract

The Coronavirus disease 2019 (COVID-19) pandemic has killed over two hundred thousand people by end of April, 2020. America and Europe top in deaths from COVID-19 whereas the numbers are lower in Africa for unclear reasons. Emerging evidence suggests the role of hyperactive immune responses characterised by high pro-inflammatory cytokines in severe cases of COVID-19 and deaths. In this perspective, we explore the possible factors that may contribute to mild inflammatory responses in some cases of COVID-19 by focusing on immune education, parasites, sex hormones and chronic diseases, as well as genetic tolerance. To build our perspective, evidence is also extracted from wild rodents due to their multi-tasking immune responses as a result of constant exposure to pathogens. © Samuel Munalula Munjita et al.

Entities:  

Keywords:  COVID-19; cytokines; genetics; hormones; immunity; inflammation; mild symptoms; parasites

Year:  2020        PMID： 33623561      PMCID： PMC7875730          DOI： 10.11604/pamj.supp.2020.35.2.23267

Source DB:  PubMed          Journal:  Pan Afr Med J


  25 in total

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9.  Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.

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1.  Assessing required SARS-CoV-2 blanket testing rates for possible control of the outbreak in the epicentre Lusaka province of Zambia with consideration for asymptomatic individuals: A simple mathematical modelling study.

Authors:  Joseph Sichone; Musalula Sinkala; Sody Munsaka; Mervis Kikonko; Martin Simuunza
Journal:  PLoS One       Date:  2021-04-06       Impact factor: 3.240

2.  Prevalence and factors associated with COVID-19 vaccine acceptance in Zambia: a web-based cross-sectional study.

Authors:  Steward Mudenda; Christabel Nang'andu Hikaambo; Victor Daka; Misheck Chileshe; Ruth Lindizyani Mfune; Martin Kampamba; Maisa Kasanga; Margaret Phiri; Webrod Mufwambi; Michelo Banda; Maureen Nkandu Phiri; Moses Mukosha
Journal:  Pan Afr Med J       Date:  2022-02-08
  2 in total

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