Ratios of internal doses deposited in different organs to the whole body when such organ is adopted as source of 18F-fluorodeoxyglucose, a Monte Carlo Geant4 study on a male medical internal radiation dose phantom.

In the present study, the last stable version of Monte Carlo Geant4 code known as Geant4.10.3 has been used for measuring internal dose ratios to the whole body for about 40 organs. This, by performing a Monte Carlo model of 18F-fluorodeoxyglucose (18F-FDG) inside different organs of medical internal radiation dose male phantom, mimics a human male adult of 70 kg. A dedicated Geant4 user code has been developed in the top of one offered by Geant4 Monte Carlo toolkit and so-called human phantom. Several Monte Carlo simulations have been carried out, and in each of them, we have taken up such organ as source of 18F-FDG with a small amount of radioactivity, evenly distributed across its volume, and we measure ratios of absorbed doses deposited in organs to the whole body. The results have shown that there are radiation dose contributions from surrounding organs and their gravities are so variable; some organs have near-local character; thus, almost all radiations are locally deposited, which generally do not affect surrounding ones mainly including adrenals, thyroid, clavicles, thymus, testes, bladder, pancreas, scapula and upper spine; whereas, it is not the case for many other organs in which radiation doses are deposited outside of their parent volumes. In addition, absorbed doses in some organs that have high-tissue weighting factors, namely colon, lungs, stomach, bladder, thyroid, and liver are seriously affected by radioactivity of surrounding muscle organs, the gravity of such affectation is mainly growth when a patient is identified as having hyperglycemia or undergoing a hard physical activity. Copyright:

INTRODUCTION

Today, nuclear medical imaging techniques that employ radiopharmaceuticals such as positron emission tomography (PET) scan and gamma camera are widely used around the world in many hospitals as in medical centers, and their use continues to increase sharply. Historically, when they first appeared, they brought out an interesting donation in diagnosis as in therapy of cancer. Since these techniques use radiopharmaceutical products which contain radioactive materials, the radiation protection area is a subject of many scientific researchers around the world which mainly attempt to study how to protect patient from biologic effect of ionizing radiations and at the same time obtaining a good diagnostic image quality.

During a nuclear fluorodeoxyglucose PET/computed tomography (FDG PET/CT) scan, the patient is irradiated by two distinct sources of radiations: external and internal. The dose absorbed by patient from an external radiation source comes from the CT scanner. This last is coupled to the PET scanner to well-located regions where there are probably considerable hyperfixations of the radiopharmaceutical, this by producing a fusion image in which metabolic image is superimposed on anatomical one. Whereas, the internal dose results from the intravenous injection of patient by a given radiopharmaceutical product. Through this article, we will focus on this internal contribution of radiation absorbed dose.

The accurate knowledge of doses absorbed by organs of patient injected by such radiopharmaceutical product is essential to avoid harmful effects of immediate ionizing radiation such as burns, fibrosis and cataract, and long-term effects such as cancers and leukemias. Today, these absorbed doses cannot be perfectly known; but instead, they can only be well estimated because there are many factors which limit their knowledge including heterogeneity character of the radioactivity distributed into tissue level and misunderstanding of cumulating radioactivity in a particular organ. The International Commission on Radiological Protection (ICRP) models which are based on the biokinetic data of different radiopharmaceuticals allow one to estimate radiation dose absorbed by each organ and also for effective dose received by a whole body; this is according to the radioactive activity injected and also depends on the patient's age range (adult, 15-year-old child, 10-year-old child, 5-year-old child, and 1-year-old child). For many years, some commercial and also free software have been developed to facilitate the calculation of patient dosimetric data, thereby following the ICRP models, namely MIRDOSE,[1] RADAR,[2] OLINDA/EXM,[3] DOSEFX,[4] and recently RadioPharmaDose.[5] However, the calculation of patient dosimetric data performed by these software does not take into account many factors such as the weight of the patient, his state of health, and other morphological and physiological factors.

To properly estimate internal dose absorbed by different structures assembling the body of a patient administered by a radiopharmaceutical, three different levels of structure must be taken into account, namely the organ, the tissue, and the cell. In this article, we focus on the level of the organ because we are interested in the field of radiation protection, while the other two levels are the subjects of metabolic radiotherapy. Since the knowing of the absorbed dose received by a particular patient is so more complicated task, that demand to invest anatomical information offered by CT scan and metabolic one retrieved from PET scan, we just focus on exploiting anatomical information offered by a medical internal radiation dose (MIRD) male phantom mimicking a human male adult of about 70 Kg. In this research paper, we use Monte Carlo Geant4 code which is a powerful tool for medical physics applications as it is well showed by many valuable works in radiotherapy,[678] brachytherapy,[9] and nuclear medicine.[10]

MATERIALS AND METHODS

The last known version of Geant4 is a software (version 10.3, developed by the Geant4 Collaboration, toolkit, Geant 4) has been used to perform this work. A Geant4-based user code has been developed in the top of a Geant4 example called human phantom; this aims to calculate internal doses deposited in thirty eight organs constituting the male MIRD phantom as shown in Figure 1.

Figure 1

Monte Carlo Geant4 model of male medical internal radiation dose phantom

Regarding the physics of the problem, positron is used as primary particle for mimicking FDG-F18 radiopharmaceutical product; the Geant4 physics model named emstandard_opt2 has been used in this work because it is recommended for modeling the transport of photons and charged particles for medical physics purpose. Going more into program details, thirty-eight Monte Carlo subsimulations have been carried out in Ubuntu 14 Linux operating system installed on a Lenovo Workstation that have 12 CPU cores running at speed of 3 GHz. In each of Monte Carlo simulation considered in this work, we adopt such organ as a source of 18F-FDG, and then, we calculate ratio of internal dose deposited in each organ to the whole body. To ensure a uniform distribution of positrons across such organ volume, three-dimensional positron positions are loaded from a prepared data file having the same name as the target organ with an extension of “.dat” and containing all points that belong to the organ volume. An activity (A0 = 6 Bql) has been considered in each of Monte Carlo simulation, which finally leads to simulate about 6 e + 04 positrons (taken into account that λ_F-18 = 1.05241 e-04 and N_positrons = A0/λ_F-18). Regarding F-18 decay physics process, positrons are emitted by F-18 with a given kinetic energy, and they are not always at rest during their annihilation with electrons of human tissues. The energetic distribution of positrons has been assumed to fit Rayleigh distribution where the maximum positron energy was fixed to the one corresponding to 18F decay, numerically, 634 KeV. The Rayleigh distribution shown in Figure 2 has been constructed using the following formula:

Figure 2

Energy spectrum for 18F positron emission produced by GNU-Root data analyzing

Whereas P1 = 0.2 MeV and P2 is a random number between 0 et 1.

RESULTS

Thirty-eight Monte Carlo Geant4 simulations have been considered in this work. The average CPU time spent by these Monte Carlo simulations was about 276 min for an amount of 18F-FDG of 6 Bql, which is equivalent to take about 6 e+04 positrons as primary events. The given results show ratios of absorbed doses in all organs to the whole body (RDWB) in a case in which a particular organ is presented as a source of 18F-FDG. The results are presented in Tables 1-38. The values those are styled in bold underlined font in Tables 1-38 are corresponding to ones of organs which are taken as sources of FDG-F18.

Table 1

RDWB values when brain is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	65.76	Lower large intestine	0.24	Right scapula	0.48
Head	2.15	Male genitalia	1.87	Right testis	0.43
Heart	0.2	Middle lower spine	0.41	Skull	11.62
Left adrenal	0.01	Pancreas	0.17	Small intestine	0.17
Left arm bone	0.28	Pelvis	0.28	Spleen	0.33
Left clavicle	1.28	Rib cage	0.29	Stomach	0.18
Left kidney	0.29	Right adrenal	0.30	Thymus	0.49
Left leg	1.8	Right arm bone	0.23	Thyroid	1.59
Left leg bone	0.65	Right clavicle	0.80	Trunk	0.41
Left lung	0.33	Right kidney	0.23	Upper large intestine	0.18
Left scapula	0.62	Right leg	0.96	Upper spine	2.94
Left testis	0.72	Right leg bone	0.54	Urinary bladder	0.23
Liver	0.18	Right lung	0.37

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 38

RDWB values when urinary bladder is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.02	Lower large intestine	0.65	Right scapula	0.06
Head	0.05	Male genitalia	0.52	Right testis	0.39
Heart	0.02	Middle lower spine	0.05	Skull	0.04
Left adrenal	0.01	Pancreas	0.02	Small intestine	0.20
Left arm bone	0.06	Pelvis	0.23	Spleen	0.03
Left clavicle	0.02	Rib cage	0.03	Stomach	0.04
Left kidney	0.05	Right adrenal	0.05	Thymus	0.02
Left leg	0.23	Right arm bone	0.04	Thyroid	0.06
Left leg bone	0.11	Right clavicle	0.03	Trunk	0.19
Left lung	0.04	Right kidney	0.08	Upper large intestine	0.17
Left scapula	0.07	Right leg	0.11	Upper spine	0.02
Left testis	0.43	Right leg bone	0.09	Urinary bladder	95.71
Liver	0.04	Right lung	0.02

RDWB: Ratios of absorbed doses in all organs to the whole body

DISCUSSION

We start this discussion by analyzing the ratio of internal dose to the whole body locally deposited in such organ chosen as source of 18F-FDG. With a glance, at the data in Tables 1-38, it can be seen that internal doses are not entirely locally deposited in organs in which the 18F-FDG came from; however, they are extended to neighboring organs. The gravity of this local dose deposition varies from one organ to another and depends on tissue physics and physiological characteristics on the one side and physics proprieties of radioactive substance on the other side. Indeed, the results have shown that organs in which almost ratios of the radiation doses are locally deposited are in the first place as follows: right adrenal, left adrenal, thyroid, left clavicle, right clavicle, thymus, right testis, bladder, left testis, right scapula, pancreas, left scapula, and upper spine, with values, respectively, of 99.04%, 98.94%, 98.89%, 98.67%, 98.17%, 98.01%, 96.05%, 95.71%, 94.96%, 92.88%, 92.47%, 92.03%, and 90.41%. With regard to radiation emergence, these organs are seemed to be less threatening to surrounding ones as the radiation doses seem to have nearly a local character. It should emphasize here, that, ratios of absorbed doses in the right and left sides of a given organ are not quite identical; this is due to the fact that the human body members are not perfectly symmetrical in terms of position, shape, and number. In the second place, we found the following ones: right kidney, left kidney, spleen, lower large intestine, heart, stomach, and upper large intestine, with RDWB values, respectively, of 88.54%, 86.25%, 83.64%, 78.49%, 78.19%, 74.39%, and 73.63%. The remained organs classified in the third place are presented with values between 70% and 30%, beginning with male genitalia (value of 68.56%) and ending with ribcage (38.57%). Finally, muscle organs seem to have an opposed situation; thus, quasi total absorbed doses are deposited outside volumes in which they were created. Indeed, results have shown that trunk has only value of 4.22%, left leg 27.31%, right leg 25.39%, and head 22.77%.

We continue this discussion by addressing internal dose contributions brought by surrounding organs in raising irradiation of the organ in question; organs with contributions greater or equal than 2% have been considered in this discussion. We start this part of the discussion by taking into consideration organs that have the largest tissue weighting factors and we finish by ones having the smallest ones. Indeed, the colon, lungs, and stomach are among the most radiosensitive organs with a value of 0.12, this, according to ICRP 103 (ICRP 2007). Regarding first organ, total absorbed dose seems to be relatively influenced by latent radioactivities on trunk (9.89%), pelvis (9.77%), legs organs (8.33%), middle lower spine (4.43%), and finally, on liver (4.13%). The gravity of such influence can be elevated when a patient is identified as having hyperglycemia or in case of strenuous physical activity because, physiologically, the radiotracer seems to be more cumulated in muscle parts of human body. As of lungs, the things are so different; the right lung is irradiated (about 2.39%) of radiations leaved liver and the two lungs together are irradiated of 5.97% of radiations leaved rib cage; there is also a radiation contribution from trunk to lungs by a value of 2.6% averagely. Respecting stomach, there are smallest contributions of liver (2.21%) and trunk (3.01%). Generally, it is found that the organs of high sensibility to radiations are affected by radiation state of some surrounding organs. Continually, always talking about tissue weighting factors, bladder, liver, and thyroid come to the second place, with a value of 0.08. The bladder seems to be damaged by radiation leaving trunk of about 5.74% of total internal dose received by whole body when the trunk is taken as source of 18F-FDG. There is also a contribution from legs with a value of 5.61% and colon with an average value of 2%. The liver seems to be damaged by radiation leaving trunk of about 2.59% of total internal dose received by whole body when the trunk is taken as source of 18F-FDG. With regard to the thyroid, there is a contribution from head of 18.50%, skull of 2.58%, and finally, trunk of 2.55% of total dose received by whole body. The other organs with less significance in terms of tissue-weighting factors are not discussed here.

CONCLUSION

Through this Monte Carlo Geant4 study, we have shown that the total absorbed dose of 18F-FDG deposited in such organ depends on radiation dose contributions of surrounding organs; gravity of such dependence seems to vary from strong to weak. On the other hand, we have found that organs of high sensibility to radiations, namely colon, lungs, stomach, bladder, thyroid, and liver are relatively affected by radioactivity cumulating in some surrounding organs including those of muscles, which can lead ultimately to elevate absorbed doses to the cited organs in case of hyperglycemia patient or in case of patient who undergoes strenuous physical activity in which abnormal hyperfixations will be appeared in muscle tissues.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

Table 2

RDWB values when head is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	3.78	Lower large intestine	0.27	Right scapula	0.98
Head	22.77	Male genitalia	2.87	Right testis	0.60
Heart	0.62	Middle lower spine	1.54	Skull	7.87
Left adrenal	0.03	Pancreas	0.65	Small intestine	0.28
Left arm bone	0.39	Pelvis	0.31	Spleen	0.44
Left clavicle	3.74	Rib cage	0.68	Stomach	0.28
Left kidney	0.32	Right adrenal	0.63	Thymus	2.47
Left leg	2.09	Right arm bone	0.39	Thyroid	18.50
Left leg bone	0.74	Right clavicle	2.72	Trunk	0.83
Left lung	1.05	Right kidney	0.42	Upper large intestine	0.23
Left scapula	1.17	Right leg	1.03	Upper spine	16.03
Left testis	0.54	Right leg bone	0.56	Urinary bladder	0.8
Liver	0.28	Right lung	1.12

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 3

RDWB values when heart is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.14	Lower large intestine	0.15	Right scapula	0.58
Head	0.25	Male genitalia	0.77	Right testis	0.39
Heart	78.19	Middle lower spine	1.48	Skull	0.18
Left adrenal	0.93	Pancreas	0.99	Small intestine	0.19
Left arm bone	0.24	Pelvis	0.17	Spleen	0.61
Let clavicle	0.47	Rib cage	0.54	Stomach	0.67
Left kidney	0.48	Right adrenal	1.22	Thymus	1.79
Left leg	0.67	Right arm bone	0.25	Thyroid	0.40
Left leg bone	0.26	Right clavicle	0.27	Trunk	0.60
Left lung	1.94	Right kidney	0.46	Upper large intestine	0.21
Left scapula	0.54	Right leg	0.34	Upper spine	0.21
Left testis	0.38	Right leg bone	0.19	Urinary bladder	0.15
Liver	0.99	Right lung	1.68

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 4

RDWB values when left adrenal is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.01	Lower large intestine	0.00	Right scapula	0.00
Head	0.01	Male genitalia	0.01	Right testis	0.01
Heart	0.04	Middle lower SPINE	0.10	Skull	0.01
Left adrenal	98.94	Pancreas	0.12	Small intestine	0.10
Left arm bone	0.01	Pelvis	0.01	Spleen	0.10
Left clavicle	0.02	Rib cage	0.02	Stomach	0.04
Left kidney	0.16	Right adrenal	0.09	Thymus	0.01
Left leg	0.01	Right arm bone	0.01	Thyroid	0.02
Left leg bone	0.01	Right clavicle	0.01	Trunk	0.02
Left lung	0.06	Right kidney	0.04	Upper large intestine	0.01
Left scapula	0.02	Right leg	0.00	Upper spine	0.01
Left testis	0.00	Right leg bone	0.02	Urinary bladder	0.00
Liver	0.03	Right lung	0.03

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 5

RDWB values when left arm bone is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.41	Lower large intestine	1.18	Right scapula	0.38
Head	0.62	Male genitalia	2.17	Right testis	0.74
Heart	0.65	Middle lower spine	0.76	Skull	0.51
Left adrenal	0.37	Pancreas	1.54	Small intestine	0.79
Left arm bone	66.74	Pelvis	1.01	Spleen	2.38
Left clavicle	0.46	Rib cage	1.07	Stomach	1.47
Left kidney	1.16	Right adrenal	0.34	Thymus	0.87
Left leg	1.85	Right arm bone	0.13	Thyroid	0.10
Left leg bone	0.80	Right clavicle	0.15	Trunk	1.08
Left lung	1.80	Right kidney	0.61	Upper large intestine	0.51
Left scapula	2.72	Right leg	1.16	Upper spine	0.43
Left testis	1.13	Right leg bone	0.73	Urinary bladder	0.41
Liver	0.40	Right lung	0.37

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 6

RDWB values when left clavicle is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.05	Lower large intestine	0.01	Right scapula	0.01
Head	0.08	Male genitalia	0.05	Right testis	0.03
Heart	0.02	Middle lower spine	0.03	Skull	0.06
Left adrenal	0.01	Pancreas	0.01	Small intestine	0.00
Left arm bone	0.02	Pelvis	0.00	Spleen	0.01
Left clavicle	98.67	Rib cage	0.04	Stomach	0.01
Left kidney	0.00	Right adrenal	0.00	Thymus	0.13
Left leg	0.07	Right arm bone	0.01	Thyroid	0.24
Left leg bone	0.03	Right clavicle	0.07	Trunk	0.04
Left lung	0.09	Right kidney	0.00	Upper large intestine	0.00
Left scapula	0.05	Right leg	0.03	Upper spine	0.06
Left testis	0.02	Right leg bone	0.02	Urinary bladder	0.00
Liver	0.01	Right lung	0.02

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 7

RDWB values when left kidney is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.08	Lower large intestine	0.18	Right scapula	0.08
Head	0.12	Male genitalia	0.37	Right testis	0.11
Heart	0.19	Middle lower spine	0.85	Skull	0.08
Left adrenal	2.89	Pancreas	1.26	Small intestine	0.42
Left arm bone	0.18	Pelvis	0.21	Spleen	2.20
Left clavicle	0.04	Rib cage	0.14	Stomach	0.7
Left kidney	86.25	Right adrenal	0.50	Thymus	0.03
Left leg	0.30	Right arm bone	0.06	Thyroid	0.08
Left leg bone	0.10	Right clavicle	0.07	Trunk	0.29
Left lung	0.23	Right kidney	0.50	Upper large intestine	0.40
Left scapula	0.11	Right leg	0.13	Upper spine	0.11
Left testis	0.06	Right leg bone	0.09	Urinary bladder	0.15
Liver	0.28	Right lung	0.13

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 8

RDWB values when left leg is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.67	Lower large intestine	2.16	Right scapula	0.70
Head	1.22	Male genitalia	9.89	Right testis	6.43
Heart	0.57	Middle lower spine	0.73	Skull	0.88
Left adrenal	1.59	Pancreas	0.78	Small intestine	0.74
Left arm bone	0.66	Pelvis	1.82	Spleen	0.61
Left clavicle	1.37	Rib cage	0.45	Stomach	0.42
Left kidney	1.16	Right adrenal	1.81	Thymus	0.39
Left leg	27.31	Right arm bone	0.75	Thyroid	0.10
Left leg bone	11.17	Right clavicle	0.95	Trunk	1.23
Left lung	0.74	Right kidney	1.03	Upper large intestine	0.62
Left scapula	0.74	Right leg	4.07	Upper spine	0.52
Left testis	8.34	Right leg bone	2.86	Urinary bladder	3.44
Liver	0.49	Right lung	0.57

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 9

RDWB values when left leg bone is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.44	Lower large intestine	0.99	Right scapula	0.62
Head	0.77	Male genitalia	4.65	Right testis	2.27
Heart	0.26	Middle lower spine	0.42	Skull	0.53
Left adrenal	1.03	Pancreas	0.16	Small intestine	0.45
Left arm bone	0.31	Pelvis	1.06	Spleen	0.28
Left clavicle	0.13	Rib cage	0.305	Stomach	0.38
Left kidney	0.59	Right adrenal	0.01	Thymus	0.32
Left leg	8.13	Right arm bone	0.44	Thyroid	0.35
Left leg bone	63.24	Right clavicle	0.97	Trunk	0.70
Left lung	0.29	Right kidney	0.54	Upper large intestine	0.39
Left scapula	0.40	Right leg	2.03	Upper spine	0.50
Left testis	2.96	Right leg bone	1.45	Urinary bladder	1.04
Liver	0.27	Right lung	0.29

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 10

RDWB values when left lung is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.23	Lower large intestine	0.19	Right scapula	0.51
Head	0.40	Male genitalia	1.02	Right testis	0.45
Heart	2.92	Middle lower spine	1.46	Skull	0.34
Left adrenal	1.78	Pancreas	1.49	Small intestine	0.22
Left arm bone	0.82	Pelvis	0.21	Spleen	1.45
Left clavicle	1.73	Rib cage	1.00	Stomach	1.20
Left kidney	0.72	Right adrenal	1.46	Thymus	2.22
Left leg	0.96	Right arm bone	0.17	Thyroid	0.79
Left leg bone	0.38	Right clavicle	0.38	Trunk	0.81
Left lung	68.12	Right kidney	0.39	Upper large intestine	0.20
Left scapula	2.87	Right leg	0.45	Upper spine	0.57
Left testis	0.35	Right leg bone	0.26	Urinary bladder	0.23
Liver	0.49	Right lung	0.77

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 11

RDWB values when left scapula is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.13	Lower large intestine	0.06	Right scapula	0.11
Head	0.20	Male genitalia	0.47	Right testis	0.31
Heart	0.24	Middle lower spine	0.25	Skull	0.16
Left adrenal	0.41	Pancreas	0.13	Small intestine	0.05
Left arm bone	0.50	Pelvis	0.05	Spleen	0.19
Left clavicle	0.40	Rib cage	0.67	Stomach	0.12
Left kidney	0.10	Right adrenal	0.14	Thymus	0.24
Left leg	0.38	Right arm bone	0.05	Thyroid	0.09
Left leg bone	0.14	Right clavicle	0.10	Trunk	0.23
Left lung	1.01	Right kidney	0.04	Upper large intestine	0.04
Left scapula	92.03	Right leg	0.17	Upper spine	0.28
Left testis	0.20	Right leg bone	0.11	Urinary bladder	0.06
Liver	0.07	Right lung	0.12

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 12

RDWB values when left testis is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.02	Lower large intestine	0.09	Right scapula	0.00
Head	0.02	Male genitalia	1.77	Right testis	2.43
Heart	0.01	Middle lower spine	0.02	Skull	0.02
Left adrenal	0.04	Pancreas	0.01	Small intestine	0.02
Left arm bone	0.01	Pelvis	0.03	Spleen	0.02
Left clavicle	0.01	Rib cage	0.01	Stomach	0.01
Left kidney	0.03	Right adrenal	0.03	Thymus	0.00
Left leg	0.07	Right arm bone	0.01	Thyroid	0.00
Left leg bone	0.04	Right clavicle	0.01	Trunk	0.03
Left lung	0.01	Right kidney	0.03	Upper large intestine	0.02
Left scapula	0.02	Right leg	0.04	Upper spine	0.01
Left testis	94.96	Right leg bone	0.03	Urinary bladder	0.11
Liver	0.01	Right lung	0.01

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 13

RDWB values when liver is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.22	Lower large intestine	0.48	Right scapula	0.88
Head	0.44	Male genitalia	2.00	Right testis	0.37
Heart	2.64	Middle lower spine	1.94	Skull	0.32
Left adrenal	2.27	Pancreas	4.21	Small intestine	1.50
Left arm bone	0.32	Pelvis	0.71	Spleen	1.08
Left clavicle	0.06	Rib cage	0.98	Stomach	2.21
Left kidney	1.71	Right adrenal	5.51	Thymus	0.70
Left leg	1.52	Right arm bone	1.12	Thyroid	0.16
Left leg bone	0.62	Right clavicle	0.36	Trunk	1.23
Left lung	0.94	Right kidney	4.32	Upper large intestine	2.15
Left scapula	0.48	Right leg	0.81	Upper spine	0.42
Left testis	0.64	Right leg bone	0.46	Urinary bladder	0.40
Liver	51.43	Right lung	2.39

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 14

RDWB values when lower large intestine is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.16	Lower large intestine	78.49	Right scapula	0.14
Head	0.25	Male genitalia	2.73	Right testis	2.20
Heart	0.06	Middle lower spine	0.23	Skull	0.19
Left adrenal	0.47	Pancreas	0.19	Small intestine	1.82
Left arm bone	0.38	Pelvis	1.47	Spleen	0.22
Left clavicle	0.10	Rib cage	0.09	Stomach	0.35
Left kidney	0.34	Right adrenal	0.01	Thymus	0.08
Left leg	0.87	Right arm bone	0.12	Thyroid	0.10
Left leg bone	0.43	Right clavicle	0.09	Trunk	0.63
Left lung	0.10	Right kidney	0.23	Upper large intestine	0.83
Left scapula	0.16	Right leg	0.67	Upper spine	0.17
Left testis	1.27	Right leg bone	0.51	Urinary bladder	3.56
Liver	0.16	Right lung	0.11

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 15

RDWB values when male genitalia is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.07	Lower large intestine	1.27	Right scapula	0.06
Head	0.13	Male genitalia	68.56	Right testis	11.64
Heart	0.04	Middle lower spine	0.08	Skull	0.09
Left adrenal	0.10	Pancreas	0.05	Small intestine	0.15
Left arm bone	0.07	Pelvis	0.29	Spleen	0.06
Left clavicle	0.06	Rib cage	0.05	Stomach	0.06
Left kidney	0.09	Right adrenal	0.06	Thymus	0.08
Left leg	0.85	Right arm bone	0.07	Thyroid	0.08
Left leg bone	0.46	Right clavicle	0.01	Trunk	0.21
Left lung	0.04	Right kidney	0.10	Upper large intestine	0.13
Left scapula	0.06	Right leg	0.63	Upper spine	0.09
Left testis	12.49	Right leg bone	0.40	Urinary bladder	1.20
Liver	0.05	Right lung	0.07

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 16

RDWB values when middle lower spine is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.33	Lower large intestine	0.46	Right scapula	0.88
Head	0.70	Male genitalia	1.76	Right testis	0.61
Heart	2.12	Middle lower spine	51.94	Skull	0.41
Left adrenal	4.48	Pancreas	2.70	Small intestine	1.54
Left arm bone	0.43	Pelvis	0.78	Spleen	1.37
Left clavicle	0.63	Rib cage	0.94	Stomach	1.28
Left kidney	3.53	Right adrenal	2.81	Thymus	1.26
Left leg	1.40	Right arm bone	0.39	Thyroid	0.73
Left leg bone	0.51	Right clavicle	0.48	Trunk	1.15
Left lung	1.73	Right kidney	3.61	Upper large intestine	1.13
Left scapula	0.97	Right leg	0.71	Upper spine	1.99
Left testis	0.32	Right leg bone	0.40	Urinary bladder	0.44
Liver	1.40	Right lung	1.71

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 17

RDWB values when pancreas is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.03	Lower large intestine	0.06	Right scapula	0.06
Head	0.05	Male genitalia	0.15	Right testis	0.10
Heart	0.31	Middle lower spine	0.46	Skull	0.03
Left adrenal	0.78	Pancreas	92.47	Small intestine	0.16
Left arm bone	0.08	Pelvis	0.07	Spleen	0.65
Left clavicle	0.08	Rib cage	0.09	Stomach	0.79
Left kidney	0.58	Right adrenal	0.61	Thymus	0.06
Left leg	0.14	Right arm bone	0.06	Thyroid	0.02
Left leg bone	0.06	Right clavicle	0.01	Trunk	0.18
Left lung	0.18	Right kidney	0.41	Upper large intestine	0.19
Left scapula	0.10	Right leg	0.08	Upper spine	0.04
Left testis	0.06	Right leg bone	0.04	Urinary bladder	0.04
Liver	0.55	Right lung	0.15

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 18

RDWB values when pelvis is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.25	Lower large intestine	3.70	Right scapula	0.32
Head	0.44	Male genitalia	1.99	Right testis	1.26
Heart	0.24	Middle lower spine	0.97	Skull	0.29
Left adrenal	0.32	Pancreas	0.56	Small intestine	3.54
Left arm bone	0.64	Pelvis	66.86	Spleen	0.52
Left clavicle	0.26	Rib cage	0.23	Stomach	0.56
Left kidney	0.95	Right adrenal	0.28	Thymus	0.11
Left leg	1.70	Right arm bone	0.66	Thyroid	0.28
Left leg bone	0.96	Right clavicle	0.26	Trunk	1.46
Left lung	0.23	Right kidney	1.15	Upper large intestine	2.53
Left scapula	0.28	Right leg	1.11	Upper spine	0.33
Left testis	1.45	Right leg bone	0.79	Urinary bladder	1.70
Liver	0.51	Right lung	0.33

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 19

RDWB values when rib cage is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.47	Lower large intestine	0.39	Right scapula	4.40
Head	0.92	Male genitalia	1.76	Right testis	0.73
Heart	2.55	Middle lower spine	2.30	Skull	0.60
Left adrenal	3.52	Pancreas	1.63	Small intestine	0.45
Left arm bone	1.13	Pelvis	0.32	Spleen	1.95
Left clavicle	3.31	Rib cage	38.57	Stomach	1.62
Left kidney	1.32	Right adrenal	3.32	Thymus	2.76
Left leg	1.76	Right arm bone	1.29	Thyroid	1.70
Left leg bone	0.63	Right clavicle	2.58	Trunk	1.38
Left lung	2.93	Right kidney	1.31	Upper large intestine	0.52
Left scapula	3.90	Right leg	0.86	Upper spine	1.33
Left testis	0.36	Right leg bone	0.52	Urinary bladder	0.15
Liver	1.72	Right lung	3.04

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 20

RDWB values when right adrenal is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.01	Lower large intestine	0.00	Right scapula	0.01
Head	0.01	Male genitalia	0.01	Right testis	0.01
Heart	0.03	Middle lower spine	0.09	Skull	0.01
Left adrenal	0.09	Pancreas	0.05	Small intestine	0.01
Left arm bone	0.00	Pelvis	0.01	Spleen	0.02
Left clavicle	0.00	Rib cage	0.02	Stomach	0.02
Left kidney	0.04	Right adrenal	99.04	Thymus	0.01
Left leg	0.04	Right arm bone	0.01	Thyroid	0.01
Left leg bone	0.01	Right clavicle	0.01	Trunk	0.02
Left lung	0.02	Right kidney	0.18	Upper large intestine	0.01
Left scapula	0.01	Right leg	0.01	Upper spine	0.01
Left testis	0.01	Right leg bone	0.01	Urinary bladder	0.00
Liver	0.07	Right lung	0.05

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 21

RDWB values when right arm bone is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.37	Lower large intestine	0.40	Right scapula	2.11
Head	0.54	Male genitalia	2.17	Right testis	1.33
Heart	0.65	Middle lower spine	0.72	Skull	0.36
Left adrenal	0.42	Pancreas	0.46	Small intestine	0.75
Left arm bone	0.36	Pelvis	1.02	Spleen	0.40
Left clavicle	0.49	Rib cage	0.99	Stomach	0.27
Left kidney	0.35	Right adrenal	1.17	Thymus	0.50
Left leg	2.18	Right arm bone	69.08	Thyroid	0.02
Left leg bone	0.94	Right clavicle	0.84	Trunk	1.13
Left lung	0.43	Right kidney	1.32	Upper large intestine	1.23
Left scapula	0.33	Right leg	1.06	Upper spine	0.45
Left testis	0.41	Right leg bone	0.58	Urinary bladder	0.44
Liver	1.86	Right lung	1.87

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 22

RDWB values when right clavicle is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.05	Lower large intestine	0.02	Right scapula	0.05
Head	0.08	Male genitalia	0.12	Right testis	0.05
Heart	0.03	Middle lower spine	0.04	Skull	0.06
Left adrenal	0.01	Pancreas	0.02	Small intestine	0.02
Left arm bone	0.03	Pelvis	0.02	Spleen	0.04
Left clavicle	0.04	Rib cage	0.05	Stomach	0.01
Left kidney	0.07	Right adrenal	0.06	Thymus	0.12
Left leg	0.09	Right arm bone	0.03	Thyroid	0.25
Left leg bone	0.03	Right clavicle	98.17	Trunk	0.06
Left lung	0.03	Right kidney	0.05	Upper large intestine	0.02
Left scapula	0.02	Right leg	0.04	Upper spine	0.05
Left testis	0.03	Right leg bone	0.03	Urinary bladder	0.03
Liver	0.02	Right lung	0.09

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 23

RDWB values when right kidney is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.05	Lower large intestine	0.10	Right scapula	0.12
Head	0.09	Male genitalia	0.28	Right testis	0.12
Heart	0.19	Middle lower spine	0.87	Skull	0.06
Left adrenal	0.50	Pancreas	0.43	Small intestine	0.42
Left arm bone	0.06	Pelvis	0.21	Spleen	0.20
Left clavicle	0.05	Rib cage	0.15	Stomach	0.27
Left kidney	0.50	Right adrenal	3.29	Thymus	0.06
Left leg	0.28	Right arm bone	0.19	Thyroid	0.08
Left leg bone	0.11	Right clavicle	0.07	Trunk	0.28
Left lung	0.12	Right kidney	88.54	Upper large intestine	0.44
Left scapula	0.06	Right leg	0.17	Upper spine	0.09
Left testis	0.08	Right leg bone	0.08	Urinary bladder	0.13
Liver	1.02	Right lung	0.26

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 24

RDWB values when right leg is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.68	Lower large intestine	3.29	Right scapula	0.63
Head	1.18	Male genitalia	11.37	Right testis	7.13
Heart	0.39	Middle lower spine	0.73	Skull	0.88
Left adrenal	1.59	Pancreas	0.64	Small intestine	0.90
Left arm bone	0.83	Pelvis	1.73	Spleen	0.56
Left clavicle	1.11	Rib cage	0.44	Stomach	0.47
Left kidney	1.08	Right adrenal	0.49	Thymus	0.32
Left leg	6.05	Right arm bone	0.43	Thyroid	1.24
Left leg bone	3.26	Right clavicle	0.68	Trunk	1.19
Left lung	0.55	Right kidney	0.93	Upper large intestine	0.62
Left scapula	0.90	Right leg	25.39	Upper spine	0.57
Left testis	7.56	Right leg bone	11.07	Urinary bladder	2.17
Liver	0.37	Right lung	0.58

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 25

RDWB values when right leg bone is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.44	Lower large intestine	1.53	Right scapula	0.62
Head	0.71	Male genitalia	4.26	Right testis	2.68
Heart	0.23	Middle lower spine	0.40	Skull	0.54
Left adrenal	2.22	Pancreas	0.20	Small intestine	0.44
Left arm bone	0.58	Pelvis	1.16	Spleen	0.43
Left clavicle	0.27	Rib cage	0.29	Stomach	0.28
Left kidney	0.46	Right adrenal	0.66	Thymus	0.20
Left leg	3.42	Right arm bone	0.24	Thyroid	0.21
Left leg bone	1.72	Right clavicle	0.00	Trunk	0.70
Left lung	0.28	Right kidney	0.59	Upper large intestine	0.32
Left scapula	0.49	Right leg	6.71	Upper spine	0.28
Left testis	2.71	Right leg bone	61.91	Urinary bladder	1.17
Liver	0.28	Right lung	0.35

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 26

RDWB values when right lung is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.25	Lower large intestine	0.17	Right scapula	3.09
Head	0.46	Male genitalia	1.10	Right testis	0.26
Heart	2.48	Middle lower spine	1.41	Skull	0.33
Left adrenal	0.93	Pancreas	0.66	Small intestine	0.21
Left arm bone	0.19	Pelvis	0.21	Spleen	0.46
Left clavicle	0.62	Rib cage	0.99	Stomach	0.40
Left kidney	0.38	Right adrenal	2.63	Thymus	1.24
Left leg	0.96	Right arm bone	0.87	Thyroid	0.52
Left leg bone	0.38	Right clavicle	2.36	Trunk	0.79
Left lung	0.78	Right kidney	0.86	Upper large intestine	0.24
Left scapula	0.48	Right leg	0.50	Upper spine	0.53
Left testis	0.46	Right leg bone	0.28	Urinary bladder	0.21
Liver	1.48	Right lung	69.86

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 27

RDWB values when right scapula is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.10	Lower large intestine	0.05	Right scapula	92.88
Head	0.23	Male genitalia	0.37	Right testis	0.15
Heart	0.25	Middle lower spine	0.25	Skull	0.14
Left adrenal	0.02	Pancreas	0.08	Small intestine	0.04
Left arm bone	0.07	Pelvis	0.04	Spleen	0.05
Left clavicle	0.08	Rib cage	0.64	Stomach	0.06
Left kidney	0.08	Right adrenal	0.27	Thymus	0.25
Left leg	0.34	Right arm bone	0.45	Thyroid	0.27
Left leg bone	0.13	Right clavicle	0.23	Trunk	0.22
Left lung	0.12	Right kidney	0.08	Upper large intestine	0.04
Left scapula	0.07	Right leg	0.17	Upper spine	0.31
Left testis	0.20	Right leg bone	0.10	Urinary bladder	0.03
Liver	0.13	Right lung	1.01

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 28

RDWB values when right testis is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.01	Lower large intestine	0.01	Right scapula	0.01
Head	0.01	Male genitalia	1.48	Right testis	96.05
Heart	0.01	Middle lower spine	0.01	Skull	0.01
Left adrenal	0.01	Pancreas	0.00	Small intestine	0.02
Left arm bone	0.01	Pelvis	0.04	Spleen	0.00
Left clavicle	0.00	Rib cage	0.01	Stomach	0.01
Left kidney	0.01	Right adrenal	0.00	Thymus	0.00
Left leg	0.07	Right arm bone	0.01	Thyroid	0.00
Left leg bone	0.04	Right clavicle	0.01	Trunk	0.03
Left lung	0.01	Right kidney	0.01	Upper large intestine	0.01
Left scapula	0.02	Right leg	0.06	Upper spine	0.01
Left testis	1.76	Right leg bone	0.04	Urinary bladder	0.11
Liver	0.00	Right lung	0.01

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 29

RDWB values when skull is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	10.46	Lower large intestine	0.25	Right scapula	0.61
Head	3.73	Male genitalia	1.99	Right testis	0.55
Heart	0.25	Middle lower spine	0.56	Skull	59.33
Left adrenal	0.09	Pancreas	0.22	Small intestine	0.18
Left arm bone	0.24	Pelvis	0.32	Spleen	0.20
Left clavicle	1.80	Rib cage	0.29	Stomach	0.19
Left kidney	0.29	Right adrenal	0.43	Thymus	0.42
Left leg	1.72	Right arm bone	0.21	Thyroid	2.58
Left leg bone	0.63	Right clavicle	1.84	Trunk	0.42
Left lung	0.38	Right kidney	0.17	Upper large intestine	0.14
Left scapula	0.60	Right leg	0.85	Upper spine	5.96
Left testis	0.79	Right leg bone	0.50	Urinary bladder	0.15
Liver	0.21	Right lung	0.47

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 30

RDWB values when small intestine is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.18	Lower large intestine	3.07	Right scapula	0.38
Head	0.37	Male genitalia	1.77	Right testis	0.75
Heart	0.32	Middle lower spine	1.64	Skull	0.26
Left adrenal	0.80	Pancreas	1.00	Small intestine	60.21
Left arm bone	0.50	Pelvis	2.75	Spleen	0.94
Left clavicle	0.05	Rib cage	0.24	Stomach	1.45
Left kidney	1.70	Right adrenal	0.36	Thymus	0.11
Left leg	1.26	Right arm bone	0.48	Thyroid	0.32
Left leg bone	0.52	Right clavicle	0.26	Trunk	1.21
Left lung	0.28	Right kidney	1.93	Upper large intestine	9.34
Left scapula	0.32	Right leg	0.74	Upper spine	0.21
Left testis	0.49	Right leg bone	0.44	Urinary bladder	1.79
Liver	1.22	Right lung	0.33

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 31

RDWB values when spleen is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.06	Lower large intestine	0.18	Right scapula	0.14
Head	0.14	Male genitalia	0.30	Right testis	0.10
Heart	0.35	Middle lower spine	0.46	Skull	0.07
Left adrenal	1.53	Pancreas	3.37	Small intestine	0.27
Left arm bone	0.44	Pelvis	0.14	Spleen	83.64
Left clavicle	0.30	Rib cage	0.27	Stomach	1.59
Left kidney	2.74	Right adrenal	0.22	Thymus	0.11
Left leg	0.36	Right arm bone	0.06	Thyroid	0.03
Left leg bone	0.14	Right clavicle	0.06	Trunk	0.34
Left lung	0.77	Right kidney	0.31	Upper large intestine	0.25
Left scapula	0.24	Right leg	0.21	Upper spine	0.10
Left testis	0.17	Right leg bone	0.11	Urinary bladder	0.05
Liver	0.23	Right lung	0.15

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 32

RDWB values when stomach is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.14	Lower large intestine	0.51	Right scapula	0.16
Head	0.21	Male genitalia	0.82	Right testis	0.34
Heart	0.83	Middle lower spine	0.69	Skull	0.18
Left adrenal	0.84	Pancreas	5.65	Small intestine	0.84
Left arm bone	0.53	Pelvis	0.31	Spleen	2.83
Left clavicle	0.11	Rib cage	0.40	Stomach	74.39
Left kidney	1.54	Right adrenal	0.64	Thymus	0.17
Left leg	0.77	Right arm bone	0.12	Thyroid	0.35
Left leg bone	0.29	Right clavicle	0.18	Trunk	0.60
Left lung	0.96	Right kidney	0.58	Upper large intestine	1.11
Left scapula	0.33	Right leg	0.40	Upper spine	0.14
Left testis	0.29	Right leg bone	0.23	Urinary bladder	0.27
Liver	0.95	Right lung	0.27

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 33

RDWB values when thymus is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.03	Lower large intestine	0.01	Right scapula	0.04
Head	0.05	Male genitalia	0.17	Right testis	0.05
Heart	0.14	Middle lower spine	0.06	Skull	0.03
Left adrenal	0.01	Pancreas	0.03	Small intestine	0.01
Left arm bone	0.03	Pelvis	0.00	Spleen	0.02
Left clavicle	0.25	Rib cage	0.07	Stomach	0.02
Left kidney	0.01	Right adrenal	0.01	Thymus	98.01
Left leg	0.04	Right arm bone	0.02	Thyroid	0.16
Left leg bone	0.02	Right clavicle	0.13	Trunk	0.06
Left lung	0.16	Right kidney	0.02	Upper large intestine	0.01
Left scapula	0.07	Right leg	0.02	Upper spine	0.05
Left testis	0.07	Right leg bone	0.01	Urinary bladder	0.00
Liver	0.02	Right lung	0.09

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 34

RDWB values when thyroid is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.04	Lower large intestine	0.00	Right scapula	0.02
Head	0.19	Male genitalia	0.02	Right testis	0.01
Heart	0.02	Middle lower spine	0.02	Skull	0.00
Left adrenal	0.00	Pancreas	0.01	Small intestine	0.00
Left arm bone	0.01	Pelvis	0.00	Spleen	0.00
Left clavicle	0.12	Rib cage	0.01	Stomach	0.01
Left kidney	0.00	Right adrenal	0.01	Thymus	0.09
Left leg	0.03	Right arm bone	0.01	Thyroid	98.89
Left leg bone	0.01	Right clavicle	0.19	Trunk	0.02
Left lung	0.02	Right kidney	0.00	Upper large intestine	0.00
Left scapula	0.02	Right leg	0.02	Upper spine	0.09
Left testis	0.01	Right leg bone	0.01	Urinary bladder	0.00
Liver	0.01	Right lung	0.02

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 35

RDWB values when trunk is adopted as source of 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.63	Lower large intestine	3.24	Right scapula	1.74
Head	1.10	Male genitalia	4.22	Right testis	2.81
Heart	4.39	Middle lower spine	3.85	Skull	0.83
Left adrenal	3.93	Pancreas	6.13	Small intestine	3.56
Left arm bone	1.26	Pelvis	2.88	Spleen	2.51
Left clavicle	2.03	Rib cage	1.40	Stomach	3.01
Left kidney	2.75	Right adrenal	2.10	Thymus	4.05
Left leg	2.70	Right arm bone	1.12	Thyroid	2.55
Left leg bone	1.21	Right clavicle	2.48	Trunk	4.22
Left lung	2.67	Right kidney	2.77	Upper large intestine	3.09
Left scapula	1.91	Right leg	1.54	Upper spine	1.45
Left testis	1.92	Right leg bone	0.99	Urinary bladder	5.74
Liver	2.59	Right lung	2.60

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 36

RDWB values when upper large intestine is adopted as source of 18F-FDG

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.14	Lower large intestine	1.27	Right scapula	0.17
Head	0.23	Male genitalia	1.19	Right testis	0.45
Heart	0.24	Middle lower spine	0.88	Skull	0.17
Left adrenal	0.26	Pancreas	1.00	Small intestine	7.09
Left arm bone	0.28	Pelvis	1.38	Spleen	0.68
Left clavicle	0.09	Rib cage	0.16	Stomach	1.42
Left kidney	1.15	Right adrenal	0.09	Thymus	0.09
Left leg	0.86	Right arm bone	0.39	Thyroid	0.30
Left leg bone	0.34	Right clavicle	0.04	Trunk	0.73
Left lung	0.22	Right kidney	1.21	Upper large intestine	73.63
Left scapula	0.22	Right leg	0.43	Upper spine	0.14
Left testis	0.71	Right leg bone	0.26	Urinary bladder	0.64
Liver	1.16	Right lung	0.24

RDWB: Ratios of absorbed doses in all organs to the whole body

Table 37

RDWB values when upper spine is adopted as source 18F-fluorodeoxyglucose

Organ	RDWB (%)	Organ	RDWB (%)	Organ	RDWB (%)
Brain	0.59	Lower large intestine	0.05	Right scapula	0.22
Head	1.50	Male genitalia	0.41	Right testis	0.16
Heart	0.12	Middle lower spine	0.63	Skull	1.20
Left adrenal	0.01	Pancreas	0.07	Small intestine	0.04
Left arm bone	0.06	Pelvis	0.07	Spleen	0.07
Left clavicle	0.49	Rib cage	0.13	Stomach	0.04
Left kidney	0.11	Right adrenal	0.11	Thymus	0.33
Left leg	0.33	Right arm bone	0.07	Thyroid	1.06
Left leg bone	0.13	Right clavicle	0.35	Trunk	0.16
Left lung	0.20	Right kidney	0.05	Upper large intestine	0.04
Left scapula	0.21	Right leg	0.16	Upper spine	90.41
Left testis	0.08	Right leg bone	0.09	Urinary bladder	0.01
Liver	0.05	Right lung	0.20

RDWB: Ratios of absorbed doses in all organs to the whole body