Gu-Shun Lai1, Jian-Ri Li2,3,4, Shian-Shiang Wang2,3,5, Chuan-Shu Chen2,3, Chun-Kuang Yang2, Sheng-Chun Hung2,3, Chen-Li Cheng2,3, Yen-Chuan Ou3,6, Kun-Yuan Chiu7,5. 1. Division of Urology, Department of Surgery, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, Taiwan, R.O.C. 2. Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. 3. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C. 4. Department of Medicine and Nursing, Hungkuang University, Taichung, Taiwan, R.O.C. 5. Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan, R.O.C. 6. Department of Urology, Tung's Taichung MetroHarbor Hospital, Taichung, Taiwan, R.O.C. 7. Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.; powerxyz17@gmail.com.
Abstract
BACKGROUND/AIM: To investigate the prognostic values of fat invasion (FI) and renal vein invasion (RVI) in pT3a renal cell carcinoma (RCC), as single factors or concomitant presence. PATIENTS AND METHODS: We retrospectively reviewed the data of 173 patients who underwent radical or partial nephrectomy for RCC in our Institution. RESULTS: At a median follow-up time of 48 months, patients with RVI showed significantly increased risk of disease recurrence and worse cancer-specific survival (CSS) when compared to those with FI (p=0.007, p=0.022, respectively). Having combined RVI and FI did not show inferior prognosis compared to those with RVI only. In multivariable analysis, RVI was an independent factor for disease recurrence (HR=2.06, 95% CI=1.10-3.87, p=0.024) and CSS (HR=2.46, 95% CI=1.01-6.0, p=0.048). CONCLUSION: For patients with T3a renal tumors, RVI was associated with inferior prognosis compared to those with FI. Copyright
BACKGROUND/AIM: To investigate the prognostic values of fat invasion (FI) and renal vein invasion (RVI) in pT3a renal cell carcinoma (RCC), as single factors or concomitant presence. PATIENTS AND METHODS: We retrospectively reviewed the data of 173 patients who underwent radical or partial nephrectomy for RCC in our Institution. RESULTS: At a median follow-up time of 48 months, patients with RVI showed significantly increased risk of disease recurrence and worse cancer-specific survival (CSS) when compared to those with FI (p=0.007, p=0.022, respectively). Having combined RVI and FI did not show inferior prognosis compared to those with RVI only. In multivariable analysis, RVI was an independent factor for disease recurrence (HR=2.06, 95% CI=1.10-3.87, p=0.024) and CSS (HR=2.46, 95% CI=1.01-6.0, p=0.048). CONCLUSION: For patients with T3a renal tumors, RVI was associated with inferior prognosis compared to those with FI. Copyright
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