Song VAN Nguyen1, Levar Shamoun2,3, Kalle Landerholm4, Roland E Andersson4, Dick Wagsater3, Jan Dimberg5. 1. Department of Medical Laboratory, Danang University of Medical Technology and Pharmacy, Danang, Vietnam. 2. Department of Laboratory Medicine and Pathology, Region Jönköping County, Jönköping, Sweden. 3. Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. 4. Department of Surgery, Region Jönköping County, Jönköping, Sweden; Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden. 5. Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Jönköping, Sweden jan.dimberg@ju.se.
Abstract
BACKGROUND/AIM: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), transiently expressed on T cells, plays a pivotal role in the negative feedback regulation of T-cell activation and proliferation. The aim of the present study was to examine the influence of CTLA-4 gene polymorphism rs3087243 on CRC susceptibility and long-term survival in Swedish patients with CRC. PATIENTS AND METHODS: Genotypes of 491 patients and 433 healthy controls were determined, using TaqMan single nucleotide polymorphism (SNP) assays based on polymerase chain reaction. RESULTS: Patients carrying allele A were found to be at a higher risk of CRC and this allele was found to be more common in patients with disseminated disease compared to localized disease in the right colon. Kaplan-Meier analysis of cancer-specific survival showed that carriers of allele A had the highest risk of CRC-related death. CONCLUSION: The SNP rs3087243 of the CTLA-4 gene was associated with CRC risk and, therefore, it could be a prognostic marker for Swedish patients with CRC. Copyright
BACKGROUND/AIM: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), transiently expressed on T cells, plays a pivotal role in the negative feedback regulation of T-cell activation and proliferation. The aim of the present study was to examine the influence of CTLA-4 gene polymorphism rs3087243 on CRC susceptibility and long-term survival in Swedish patients with CRC. PATIENTS AND METHODS: Genotypes of 491 patients and 433 healthy controls were determined, using TaqMan single nucleotide polymorphism (SNP) assays based on polymerase chain reaction. RESULTS: Patients carrying allele A were found to be at a higher risk of CRC and this allele was found to be more common in patients with disseminated disease compared to localized disease in the right colon. Kaplan-Meier analysis of cancer-specific survival showed that carriers of allele A had the highest risk of CRC-related death. CONCLUSION: The SNP rs3087243 of the CTLA-4 gene was associated with CRC risk and, therefore, it could be a prognostic marker for Swedish patients with CRC. Copyright
Authors: Mahul B Amin; Frederick L Greene; Stephen B Edge; Carolyn C Compton; Jeffrey E Gershenwald; Robert K Brookland; Laura Meyer; Donna M Gress; David R Byrd; David P Winchester Journal: CA Cancer J Clin Date: 2017-01-17 Impact factor: 508.702
Authors: Reiko Nishihara; Kimberly Glass; Kosuke Mima; Tsuyoshi Hamada; Jonathan A Nowak; Zhi Rong Qian; Peter Kraft; Edward L Giovannucci; Charles S Fuchs; Andrew T Chan; John Quackenbush; Shuji Ogino; Jukka-Pekka Onnela Journal: BMC Bioinformatics Date: 2017-06-17 Impact factor: 3.169