Jung Ho Lee1, Sung-Hee Cho2, Eun Hye Jang1, Soon Ae Kim3. 1. Department of Pharmacology, School of Medicine, Eulji University, Daejeon, Republic of Korea. 2. Chemical Analysis Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Republic of Korea. 3. Department of Pharmacology, School of Medicine, Eulji University, Daejeon, Republic of Korea; sakim@eulji.ac.kr.
Abstract
BACKGROUND/AIM: In this study, we investigated sex-specific effects of acute exposure to trimethyltin, a known neurotoxicant on metabolic steroids. MATERIALS AND METHODS: We administered intraperitoneally 2.3 mg/kg trimethyltin to 4-week-old male mice and measured the levels of metabolic steroids 24 h after treatment. We also measured mRNA and protein levels of cytochrome P450 1B1 using real-time polymerase chain reaction and western blotting. RESULTS: Cortisol levels in the cortex increased in both sexes following acute trimethyltin exposure. The estradiol levels decreased, and the 4-hydroxyestradiol levels increased only in females. We also observed increased cytochrome P450 1B1 mRNA and protein levels only in the female cortex. CONCLUSION: Acute trimethyltin exposure induces distinct sex-specific metabolic changes in the brain before significant sexual maturation. Copyright
BACKGROUND/AIM: In this study, we investigated sex-specific effects of acute exposure to trimethyltin, a known neurotoxicant on metabolic steroids. MATERIALS AND METHODS: We administered intraperitoneally 2.3 mg/kg trimethyltin to 4-week-old male mice and measured the levels of metabolic steroids 24 h after treatment. We also measured mRNA and protein levels of cytochrome P450 1B1 using real-time polymerase chain reaction and western blotting. RESULTS:Cortisol levels in the cortex increased in both sexes following acute trimethyltin exposure. The estradiol levels decreased, and the 4-hydroxyestradiol levels increased only in females. We also observed increased cytochrome P450 1B1 mRNA and protein levels only in the female cortex. CONCLUSION: Acute trimethyltin exposure induces distinct sex-specific metabolic changes in the brain before significant sexual maturation. Copyright
Authors: John J Cho; Francesco A Iannucci; Melissa Fraile; Joseph Franco; Tracy N Alesius; George B Stefano Journal: Neuro Endocrinol Lett Date: 2003 Jun-Aug Impact factor: 0.765
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