Literature DB >> 33622860

Osteochondromas: An Updated Review of Epidemiology, Pathogenesis, Clinical Presentation, Radiological Features and Treatment Options.

Kostas Tepelenis1, Georgios Papathanakos2, Aikaterini Kitsouli3, Theodoros Troupis4, Alexandra Barbouti3, Konstantinos Vlachos5, Panagiotis Kanavaros3, Panagiotis Kitsoulis3,6.   

Abstract

Osteochondroma, the most common benign bone tumor, is a projection on the external surface of the bone, which can be sessile or pedunculated. 85% of osteochondromas present as solitary lesions, while 15% occur in the context of hereditary multiple exostoses (HME), a genetic disorder that is inherited in an autosomal dominant manner. Although often asymptomatic, symptoms may eventuate from compression of adjacent vessels or nerves, fractures, osseous deformities, bursa formation, or malignant transformation. Cartilage cap thickness >2 cm in adults or >3 cm in children as well as new onset of pain or growth, or rapid growth of the lesion, especially after the closure of the growth plate, might reflect cancerous transformation. Surgical resection is indicated for symptomatic lesions, complications, cosmetic reasons or malignant transformation. Excision of the tumor with free margin is the treatment of choice. Local recurrence is less than 2% if complete resection is achieved. Copyright
© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Entities:  

Keywords:  HME; Osteochondroma; chondrosarcoma; exostosis; imaging; review

Year:  2021        PMID: 33622860      PMCID: PMC8045119          DOI: 10.21873/invivo.12308

Source DB:  PubMed          Journal:  In Vivo        ISSN: 0258-851X            Impact factor:   2.155


  117 in total

1.  Compartment syndrome associated with an osteocartilaginous exostosis.

Authors:  J Van Oost; J Feyen; J Opheide
Journal:  Acta Orthop Belg       Date:  1996-12       Impact factor: 0.500

2.  Natural history of multiple hereditary osteochondromatosis of the lower extremity and ankle.

Authors:  Kenneth J Noonan; Judy R Feinberg; Anthony Levenda; James Snead; L Daniel Wurtz
Journal:  J Pediatr Orthop       Date:  2002 Jan-Feb       Impact factor: 2.324

Review 3.  The imaging of cartilaginous bone tumours. I. Benign lesions.

Authors:  H Douis; A Saifuddin
Journal:  Skeletal Radiol       Date:  2012-06-17       Impact factor: 2.199

4.  The natural history of hereditary multiple exostoses.

Authors:  G A Schmale; E U Conrad; W H Raskind
Journal:  J Bone Joint Surg Am       Date:  1994-07       Impact factor: 5.284

5.  Retinoid signaling is required for chondrocyte maturation and endochondral bone formation during limb skeletogenesis.

Authors:  E Koyama; E B Golden; T Kirsch; S L Adams; R A Chandraratna; J J Michaille; M Pacifici
Journal:  Dev Biol       Date:  1999-04-15       Impact factor: 3.582

6.  Severity of disease and risk of malignant change in hereditary multiple exostoses. A genotype-phenotype study.

Authors:  D E Porter; L Lonie; M Fraser; C Dobson-Stone; J R Porter; A P Monaco; A H R W Simpson
Journal:  J Bone Joint Surg Br       Date:  2004-09

7.  Osteochondroma in the mandibular condyle that caused facial asymmetry: a case report.

Authors:  Makoto Koga; Shisei Toyofuku; Yasuhiro Nakamura; Kazunori Yoshiura; Jingo Kusukawa; Yoshiaki Nakamura
Journal:  Cranio       Date:  2006-01       Impact factor: 2.020

8.  The treatment of hereditary multiple exostosis of the upper extremity.

Authors:  V E Wood; D Sauser; D Mudge
Journal:  J Hand Surg Am       Date:  1985-07       Impact factor: 2.230

Review 9.  The solitary intraspinal vertebral osteochondroma. An unusual cause of compressive myelopathy: features and literature review.

Authors:  A Khosla; D S Martin; E E Awwad
Journal:  Spine (Phila Pa 1976)       Date:  1999-01-01       Impact factor: 3.468

10.  RNA-Seq detects a SAMD12-EXT1 fusion transcript and leads to the discovery of an EXT1 deletion in a child with multiple osteochondromas.

Authors:  Gavin R Oliver; Patrick R Blackburn; Marissa S Ellingson; Erin Conboy; Filippo Pinto E Vairo; Matthew Webley; Erik Thorland; Matthew Ferber; Els Van Hul; Ilse M van der Werf; Wim Wuyts; Dusica Babovic-Vuksanovic; Eric W Klee
Journal:  Mol Genet Genomic Med       Date:  2019-01-10       Impact factor: 2.183

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  9 in total

Review 1.  Vascular Complications Caused by Tibial Osteochondroma: Focus on the Literature and Presentation of a Popliteal Artery Thrombosis with Acute Lower Limb Ischemia.

Authors:  Andrea Angelini; Mariachiara Cerchiaro; Carlo Maturi; Pietro Ruggieri
Journal:  Diagnostics (Basel)       Date:  2022-05-10

2.  Novel techniques for solitary atlas osteochondroma: a case report and literature review.

Authors:  Yongyuan Zhang; Xiaohui Wang; Chao Jiang; Zhe Chen; Biao Wang; Honghui Sun; Dingjun Hao
Journal:  Am J Transl Res       Date:  2022-02-15       Impact factor: 4.060

3.  Unusual location of osteochondroma in the temporal region in a patient with functional pituitary adenoma.

Authors:  Henry Olayere Obanife; Akaba Kingsley; John Ashindointiang; Joseph Asuquo; Olabisi Ogunleye; Iwasam E Joshua
Journal:  J Int Med Res       Date:  2021-12       Impact factor: 1.671

4.  Clinical survey of a pedigree with hereditary multiple exostoses and identification of EXT‑2 gene deletion mutation.

Authors:  Wentao Wang; Mingyuan Yang; Yuhang Shen; Kai Chen; Donghua Wu; Changwei Yang; Jinyi Bai; Dawei He; Jun Gao
Journal:  Mol Med Rep       Date:  2022-02-25       Impact factor: 2.952

5.  Recurrent Intra Articular Osteochondroma of Left 4th Finger.

Authors:  Shanmuga Sundaram Palaniswamy; Padma Subramanyam
Journal:  Indian J Nucl Med       Date:  2022-07-08

Review 6.  Hemothorax caused by costal exostosis injuring diaphragm: a case report and literature review.

Authors:  Ruonan Pan; Xiaoqian Lu; Zhijun Wang; Lijun Duan; Dianbo Cao
Journal:  J Cardiothorac Surg       Date:  2022-09-06       Impact factor: 1.522

7.  A Unique Case of Recurrent Osteochondroma Enclosing Brachial Artery in a 13-Year-Old Female.

Authors:  Sachin Yashwant Kale; Shivam Mehra; Aditya Gunjotikar; Raju Patil; Pratik Dhabalia; Sushmit Singh
Journal:  J Orthop Case Rep       Date:  2022-03

8.  Application of allograft and absorbable screws in the reconstruction of a massive bone defect following resection of giant osteochondroma: A retrospective study.

Authors:  Zhihao Ma; Qiang Yang; Xinyu Liu; Zhenfeng Li
Journal:  Front Surg       Date:  2022-09-22

9.  Ischial osteochondroma as an unusual source of pregnancy-related sciatic pain: a case report.

Authors:  Robert J Trager; Sarah E Prosak; Patrick J Getty; Richard L Barger; Shahrazad T Saab; Jeffery A Dusek
Journal:  Chiropr Man Therap       Date:  2022-10-17
  9 in total

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