| Literature DB >> 33622471 |
Pranay R Randad, Jesper Larsen, Hülya Kaya, Nora Pisanic, Carly Ordak, Lance B Price, Maliha Aziz, Maya L Nadimpalli, Sarah Rhodes, Jill R Stewart, Dave C Love, David Mohr, Meghan F Davis, Lloyd S Miller, Devon Hall, Karen C Carroll, Trish M Perl, Christopher D Heaney.
Abstract
Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0-34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.Entities:
Keywords: AMR; MRSA and other staphylococci; North Carolina; Staphylococcus aureus; United States; antimicrobial resistance; bacteria; food safety; industrial hog operations; infectious disease transmission; livestock-associated diseases; multidrug-resistant bacteria; pigs; zoonoses; zoonotic transmission
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Year: 2021 PMID： 33622471 PMCID： PMC7920674 DOI： 10.3201/eid2703.191775
Source DB: PubMed Journal: Emerg Infect Dis ISSN： 1080-6040 Impact factor: 6.883