Literature DB >> 33622388

Mechanism of mesenchymal stem cells in spinal cord injury repair through macrophage polarization.

Nan An1,2, Jiaxu Yang1,3, Hequn Wang1,3, Shengfeng Sun1,3, Hao Wu1,3, Lisha Li4, Meiying Li5.   

Abstract

Treatment and rehabilitation of spinal cord injury (SCI) is a major problem in clinical medicine. Modern medicine has achieved minimal progress in improving the functions of injured nerves in patients with SCI, mainly due to the complex pathophysiological changes that present after injury. Inflammatory reactions occurring after SCI are related to various functions of immune cells over time at different injury sites. Macrophages are important mediators of inflammatory reactions and are divided into two different subtypes (M1 and M2), which play important roles at different times after SCI. Mesenchymal stem cells (MSCs) are characterized by multi-differentiation and immunoregulatory potentials, and different treatments can have different effects on macrophage polarization. MSC transplantation has become a promising method for eliminating nerve injury caused by SCI and can help repair injured nerve tissues. Therapeutic effects are related to the induced formation of specific immune microenvironments, caused by influencing macrophage polarization, controlling the consequences of secondary injury after SCI, and assisting with function recovery. Herein, we review the mechanisms whereby MSCs affect macrophage-induced specific immune microenvironments, and discuss potential avenues of investigation for improving SCI treatment.

Entities:  

Keywords:  Inflammatory microenvironment; Macrophage polarization; Mesenchymal stem cells; Spinal cord injury

Year:  2021        PMID： 33622388      PMCID： PMC7903655          DOI： 10.1186/s13578-021-00554-z

Source DB:  PubMed          Journal:  Cell Biosci        ISSN： 2045-3701            Impact factor:   7.133


  136 in total

1.  Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.

Authors:  Kristina A Kigerl; John C Gensel; Daniel P Ankeny; Jessica K Alexander; Dustin J Donnelly; Phillip G Popovich
Journal:  J Neurosci       Date:  2009-10-28       Impact factor: 6.167

2.  Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes.

Authors:  Wei Liu; Yongxiang Wang; Fangyi Gong; Yuluo Rong; Yongjun Luo; Pengyu Tang; Zheng Zhou; Zhimin Zhou; Tao Xu; Tao Jiang; Siting Yang; Guoyong Yin; Jian Chen; Jin Fan; Weihua Cai
Journal:  J Neurotrauma       Date:  2018-08-13       Impact factor: 5.269

3.  Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.

Authors:  Alicia Arranz; Christina Doxaki; Eleni Vergadi; Yeny Martinez de la Torre; Katerina Vaporidi; Eleni D Lagoudaki; Eleftheria Ieronymaki; Ariadne Androulidaki; Maria Venihaki; Andrew N Margioris; Efstathios N Stathopoulos; Philip N Tsichlis; Christos Tsatsanis
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-30       Impact factor: 11.205

Review 4.  Monocyte chemoattractant protein-1 (MCP-1): an overview.

Authors:  Satish L Deshmane; Sergey Kremlev; Shohreh Amini; Bassel E Sawaya
Journal:  J Interferon Cytokine Res       Date:  2009-06       Impact factor: 2.607

5.  Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells.

Authors:  Chung-Hsin Yeh; Hung-Che Shih; Hui-Mei Hong; Shiuan-Shinn Lee; Ming-Ling Yang; Chun-Jung Chen; Yu-Hsiang Kuan
Journal:  Toxicol Ind Health       Date:  2013-04-16       Impact factor: 2.273

6.  Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

Authors:  Chiara Porta; Monica Rimoldi; Geert Raes; Lea Brys; Pietro Ghezzi; Diana Di Liberto; Francesco Dieli; Serena Ghisletti; Gioacchino Natoli; Patrick De Baetselier; Alberto Mantovani; Antonio Sica
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-17       Impact factor: 11.205

7.  Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation.

Authors:  Ajit Sodhi; Subhra K Biswas
Journal:  J Interferon Cytokine Res       Date:  2002-05       Impact factor: 2.607

Review 8.  Regulation of Inflammatory Cytokines for Spinal Cord Injury Repair Through Local Delivery of Therapeutic Agents.

Authors:  Hao Ren; Xuri Chen; Mengya Tian; Jing Zhou; Hongwei Ouyang; Zhiyong Zhang
Journal:  Adv Sci (Weinh)       Date:  2018-07-31       Impact factor: 16.806

9.  The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit.

Authors:  Jonathon Chon Teng Chio; Jian Wang; Anna Badner; James Hong; Vithushan Surendran; Michael G Fehlings
Journal:  J Neuroinflammation       Date:  2019-07-09       Impact factor: 8.322

10.  Enhancement of Neural Stem Cell Proliferation in Rats with Spinal Cord Injury by a Combination of Repetitive Transcranial Magnetic Stimulation (rTMS) and Human Umbilical Cord Blood Mesenchymal Stem Cells (hUCB-MSCs).

Authors:  Mengguo Guo; Lixin Wu; Zhenyu Song; Bo Yang
Journal:  Med Sci Monit       Date:  2020-08-20
View more
  11 in total

1.  The human dental apical papilla promotes spinal cord repair through a paracrine mechanism.

Authors:  P De Berdt; K Vanvarenberg; B Ucakar; C Bouzin; A Paquot; V Gratpain; A Loriot; V Payen; B Bearzatto; G G Muccioli; L Gatto; A Diogenes; A des Rieux
Journal:  Cell Mol Life Sci       Date:  2022-04-21       Impact factor: 9.261

Review 2.  Regenerative Role of T Cells in Nerve Repair and Functional Recovery.

Authors:  Xiaoxuan Tang; Qiaoyuan Li; Tingting Huang; Han Zhang; Xiaoli Chen; Jue Ling; Yumin Yang
Journal:  Front Immunol       Date:  2022-07-05       Impact factor: 8.786

3.  A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury.

Authors:  Ziming Li; Tengfei Zhao; Jie Ding; Haochen Gu; Qiaoxuan Wang; Yifan Wang; Deteng Zhang; Changyou Gao
Journal:  Bioact Mater       Date:  2022-05-09

4.  Peripheral Blood-Derived Mesenchymal Stem Cells Modulate Macrophage Plasticity through the IL-10/STAT3 Pathway.

Authors:  Qi-Ming Pang; Rui Yang; Meng Zhang; Wang-Hui Zou; Nan-Nan Qian; Qi-Jing Xu; Hui Chen; Jia-Chen Peng; Xiao-Ping Luo; Qian Zhang; Tao Zhang
Journal:  Stem Cells Int       Date:  2022-04-11       Impact factor: 5.131

Review 5.  Future Perspectives in Spinal Cord Repair: Brain as Saviour? TSCI with Concurrent TBI: Pathophysiological Interaction and Impact on MSC Treatment.

Authors:  Paul Köhli; Ellen Otto; Denise Jahn; Marie-Jacqueline Reisener; Jessika Appelt; Adibeh Rahmani; Nima Taheri; Johannes Keller; Matthias Pumberger; Serafeim Tsitsilonis
Journal:  Cells       Date:  2021-10-30       Impact factor: 6.600

Review 6.  Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms.

Authors:  Atefeh Zarepour; Sara Hooshmand; Aylin Gökmen; Ali Zarrabi; Ebrahim Mostafavi
Journal:  Cells       Date:  2021-11-16       Impact factor: 6.600

7.  Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury.

Authors:  Sven Hendrix; Stefanie Lemmens; Jana Van Broeckhoven; Céline Erens; Daniela Sommer; Elle Scheijen; Selien Sanchez; Pia M Vidal; Dearbhaile Dooley; Elise Van Breedam; Alessandra Quarta; Peter Ponsaerts
Journal:  J Neuroinflammation       Date:  2022-04-29       Impact factor: 9.587

8.  Comparing the Efficacy and Safety of Cell Transplantation for Spinal Cord Injury: A Systematic Review and Bayesian Network Meta-Analysis.

Authors:  Xiongjie Xu; Zeyan Liang; Yike Lin; Jian Rao; Fabin Lin; Zhelun Yang; Rui Wang; Chunmei Chen
Journal:  Front Cell Neurosci       Date:  2022-04-04       Impact factor: 6.147

9.  The Role of Microglia/Macrophages Activation and TLR4/NF-κB/MAPK Pathway in Distraction Spinal Cord Injury-Induced Inflammation.

Authors:  Weishi Liang; Bo Han; Yong Hai; Yuzeng Liu; Xing Liu; Jincai Yang; Duan Sun; Peng Yin
Journal:  Front Cell Neurosci       Date:  2022-06-09       Impact factor: 6.147

Review 10.  Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury.

Authors:  Qi-Ming Pang; Si-Yu Chen; Sheng-Ping Fu; Hui Zhou; Qian Zhang; Jun Ao; Xiao-Ping Luo; Tao Zhang
Journal:  J Inflamm Res       Date:  2022-01-26
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.