Introduction: World Health Organization has recommended that in healthy persons with category III exposures, who receive wound care and rabies immunoglobulin infiltration, a vaccine regimen consisting of 4 doses administered intramuscularly on days 0, 3, 7, and 14 can be used as an alternative to the 5-dose intramuscular regimen.Objective: To assess the clinical safety and immunogenicity of rabies vaccine administered as 4-dose Essen intramuscular regimen for post-exposure prophylaxis. Methods: A non-randomized, comparative, controlled study was conducted at the anti-rabies clinic, KIMS Hospital and Research Center, Bangalore, India. The study subjects were divided into study group i.e., 4-dose intramuscular regimen, and control group i.e., 5-dose intramuscular regimen, and were given post-exposure prophylaxis. All subjects were followed for any adverse drug events. Rabies virus neutralizing antibodies was determined on day 14, 90 & 180 at the WHO collaborating center, NIMHANS, Bangalore, India to assess the immunogenicity. Results: The present study included 70 adult animal bite victims, 35 each in study group and control group. The incidence of ADEs was 7.8% in 4-dose Essen group and 7.0% in 5-dose Essen group;the difference between them was not significant (P > .05). Similarly, all the subjects in both the groups had protective antibody titers of ≥ 0.5 IU/mL (100% seroprotective) from day 14 till day 180; the difference between two groups was also not significant (P > .05). Conclusion: The 4-dose intramuscular Essen post-exposure prophylaxis regimen was found to be clinically safe and immunogenic.
Introduction: World Health Organization has recommended that in healthy persons with category III exposures, who receive wound care and rabies immunoglobulin infiltration, a vaccine regimen consisting of 4 doses administered intramuscularly on days 0, 3, 7, and 14 can be used as an alternative to the 5-dose intramuscular regimen.Objective: To assess the clinical safety and immunogenicity of rabies vaccine administered as 4-dose Essen intramuscular regimen for post-exposure prophylaxis. Methods: A non-randomized, comparative, controlled study was conducted at the anti-rabies clinic, KIMS Hospital and Research Center, Bangalore, India. The study subjects were divided into study group i.e., 4-dose intramuscular regimen, and control group i.e., 5-dose intramuscular regimen, and were given post-exposure prophylaxis. All subjects were followed for any adverse drug events. Rabies virus neutralizing antibodies was determined on day 14, 90 & 180 at the WHO collaborating center, NIMHANS, Bangalore, India to assess the immunogenicity. Results: The present study included 70 adult animal bite victims, 35 each in study group and control group. The incidence of ADEs was 7.8% in 4-dose Essen group and 7.0% in 5-dose Essen group;the difference between them was not significant (P > .05). Similarly, all the subjects in both the groups had protective antibody titers of ≥ 0.5 IU/mL (100% seroprotective) from day 14 till day 180; the difference between two groups was also not significant (P > .05). Conclusion: The 4-dose intramuscular Essen post-exposure prophylaxis regimen was found to be clinically safe and immunogenic.
Authors: Charles E Rupprecht; Deborah Briggs; Catherine M Brown; Richard Franka; Samuel L Katz; Harry D Kerr; Susan Lett; Robin Levis; Martin I Meltzer; William Schaffner; Paul R Cieslak Journal: Vaccine Date: 2009-11-27 Impact factor: 3.641
Authors: M K Sudarshan; B J Mahendra; S N Madhusudana; D H Ashwoath Narayana; Abdul Rahman; N S N Rao; F X-Meslin; Derek Lobo; K Ravikumar Journal: J Commun Dis Date: 2006-03
Authors: Darryn L Knobel; Sarah Cleaveland; Paul G Coleman; Eric M Fèvre; Martin I Meltzer; M Elizabeth G Miranda; Alexandra Shaw; Jakob Zinsstag; François-Xavier Meslin Journal: Bull World Health Organ Date: 2005-06-24 Impact factor: 9.408
Authors: Katie Hampson; Laurent Coudeville; Tiziana Lembo; Maganga Sambo; Alexia Kieffer; Michaël Attlan; Jacques Barrat; Jesse D Blanton; Deborah J Briggs; Sarah Cleaveland; Peter Costa; Conrad M Freuling; Elly Hiby; Lea Knopf; Fernando Leanes; François-Xavier Meslin; Artem Metlin; Mary Elizabeth Miranda; Thomas Müller; Louis H Nel; Sergio Recuenco; Charles E Rupprecht; Carolin Schumacher; Louise Taylor; Marco Antonio; Natal Vigilato; Jakob Zinsstag; Jonathan Dushoff Journal: PLoS Negl Trop Dis Date: 2015-05-11