Maxwell Pistilli1, Sapna S Gangaputra2, Siddharth S Pujari3, Douglas A Jabs4,5, Grace A Levy-Clarke6,7, Robert B Nussenblatt6, James T Rosenbaum8,9, H Nida Sen6, Eric B Suhler8,9,10, Jennifer E Thorne4,5, Nirali P Bhatt1, C Stephen Foster11,12, Hosne Begum5, Tonetta D Fitzgerald1, Kurt A Dreger1,5, John H Kempen12,13,14. 1. and the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group** Department of Ophthalmology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. 2. Department of Ophthalmology and Vision Sciences, Vanderbilt Eye Institute, Nashville, Tennessee, USA. 3. Om Eye Care Hospital, Belgaum, India. 4. Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. 5. Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 6. Laboratory of Immunology, National Eye Institute, Bethesda, Maryland, USA. 7. Tampa Bay Uveitis Center, Tampa, Florida, USA. 8. Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA. 9. Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA. 10. Portland Veteran's Affairs Medical Center, Portland, Oregon, USA. 11. Massachusetts Eye Research and Surgery Institution, Cambridge, Massachusetts, USA. 12. Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. 13. Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA. 14. MCM Eye Unit, MCM General Hospital and MyungSung Medical School, Addis Ababa, Ethiopia, USA.
Abstract
INTRODUCTION: We evaluated the associations of clinical and demographic characteristics with visual acuity (VA) with over 5 years in a subspecialty noninfectious uveitis population. METHODS: Retrospective data from 5,530 noninfectious uveitis patients were abstracted by expert reviewers, and contemporaneous associations of VA with demographic and clinical factors were modeled. RESULTS: Patients were a median of 41 years old, 65% female, and 73% white. Eyes diagnosed ≥5 years prior to cohort entry had worse VA (-1.2 lines) than those diagnosed <6 months prior, and eyes with cataract surgery performed prior to entry had worse VA (-5.9 lines) than those performed during follow-up. Vitreous haze (-4.2 lines for 3+ vs quiet), hypotony (-2.5 lines for ≤5 mm Hg vs 6-23 mm Hg), and CNV (-1.8 lines) all were strongly associated with reduced VA. CONCLUSION: Factors associated with reduced VA included well-known structural complications, and lack of subspecialty care during cataract surgery.
INTRODUCTION: We evaluated the associations of clinical and demographic characteristics with visual acuity (VA) with over 5 years in a subspecialty noninfectious uveitis population. METHODS: Retrospective data from 5,530 noninfectious uveitis patients were abstracted by expert reviewers, and contemporaneous associations of VA with demographic and clinical factors were modeled. RESULTS: Patients were a median of 41 years old, 65% female, and 73% white. Eyes diagnosed ≥5 years prior to cohort entry had worse VA (-1.2 lines) than those diagnosed <6 months prior, and eyes with cataract surgery performed prior to entry had worse VA (-5.9 lines) than those performed during follow-up. Vitreous haze (-4.2 lines for 3+ vs quiet), hypotony (-2.5 lines for ≤5 mm Hg vs 6-23 mm Hg), and CNV (-1.8 lines) all were strongly associated with reduced VA. CONCLUSION: Factors associated with reduced VA included well-known structural complications, and lack of subspecialty care during cataract surgery.
Authors: Caroline L Minkus; Maxwell Pistilli; Kurt A Dreger; Tonetta D Fitzgerald; Abhishek R Payal; Hosne Begum; R Oktay Kaçmaz; Douglas A Jabs; Robert B Nussenblatt; James T Rosenbaum; Grace A Levy-Clarke; H Nida Sen; Eric B Suhler; Jennifer E Thorne; Nirali P Bhatt; C Stephen Foster; Jeanine M Buchanich; John H Kempen Journal: Am J Ophthalmol Date: 2021-03-10 Impact factor: 5.488