Literature DB >> 33618948

Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD.

Yeyun Ouyang1, Alex J Bott1, Jared Rutter2.   

Abstract

Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major mitochondrial NAD+ transporter in mammalian cells. These studies not only deorphan an uncharacterized transporter of the SLC25A family, but also shed light on other aspects of NAD+ biology.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  NAD; SLC25A family; mitochondrial transporter; redox; respiration

Mesh：

Substances：

Year:  2021        PMID： 33618948      PMCID： PMC8344040          DOI： 10.1016/j.tibs.2021.02.001

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  9 in total

1.  Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae.

Authors:  Simona Todisco; Gennaro Agrimi; Alessandra Castegna; Ferdinando Palmieri
Journal:  J Biol Chem       Date:  2005-11-16       Impact factor: 5.157

Review 2.  NAD+ metabolism and its roles in cellular processes during ageing.

Authors:  Anthony J Covarrubias; Rosalba Perrone; Alessia Grozio; Eric Verdin
Journal:  Nat Rev Mol Cell Biol       Date:  2020-12-22       Impact factor: 94.444

3.  Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells.

Authors:  Magali R VanLinden; Christian Dölle; Ina K N Pettersen; Veronika A Kulikova; Marc Niere; Gennaro Agrimi; Sissel E Dyrstad; Ferdinando Palmieri; Andrey A Nikiforov; Karl Johan Tronstad; Mathias Ziegler
Journal:  J Biol Chem       Date:  2015-10-02       Impact factor: 5.157

4.  Biosensor reveals multiple sources for mitochondrial NAD⁺.

Authors:  Xiaolu A Cambronne; Melissa L Stewart; DongHo Kim; Amber M Jones-Brunette; Rory K Morgan; David L Farrens; Michael S Cohen; Richard H Goodman
Journal:  Science       Date:  2016-06-17       Impact factor: 47.728

5.  Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria.

Authors:  Roberta Felici; Andrea Lapucci; Matteo Ramazzotti; Alberto Chiarugi
Journal:  PLoS One       Date:  2013-10-14       Impact factor: 3.240

6.  SLC25A51 is a mammalian mitochondrial NAD+ transporter.

Authors:  Timothy S Luongo; Jared M Eller; Mu-Jie Lu; Marc Niere; Fabio Raith; Caroline Perry; Marc R Bornstein; Paul Oliphint; Lin Wang; Melanie R McReynolds; Marie E Migaud; Joshua D Rabinowitz; F Brad Johnson; Kai Johnsson; Mathias Ziegler; Xiaolu A Cambronne; Joseph A Baur
Journal:  Nature       Date:  2020-09-09       Impact factor: 49.962

7.  Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import.

Authors:  Enrico Girardi; Gennaro Agrimi; Ulrich Goldmann; Giuseppe Fiume; Sabrina Lindinger; Vitaly Sedlyarov; Ismet Srndic; Bettina Gürtl; Benedikt Agerer; Felix Kartnig; Pasquale Scarcia; Maria Antonietta Di Noia; Eva Liñeiro; Manuele Rebsamen; Tabea Wiedmer; Andreas Bergthaler; Luigi Palmieri; Giulio Superti-Furga
Journal:  Nat Commun       Date:  2020-12-01       Impact factor: 14.919

8.  Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.

Authors:  Antonio Davila; Ling Liu; Karthikeyani Chellappa; Philip Redpath; Eiko Nakamaru-Ogiso; Lauren M Paolella; Zhigang Zhang; Marie E Migaud; Joshua D Rabinowitz; Joseph A Baur
Journal:  Elife       Date:  2018-06-12       Impact factor: 8.140

9.  MCART1/SLC25A51 is required for mitochondrial NAD transport.

Authors:  Nora Kory; Jelmi Uit de Bos; Sanne van der Rijt; Nevena Jankovic; Miriam Güra; Nicholas Arp; Izabella A Pena; Gyan Prakash; Sze Ham Chan; Tenzin Kunchok; Caroline A Lewis; David M Sabatini
Journal:  Sci Adv       Date:  2020-10-21       Impact factor: 14.136
  9 in total
  1 in total

Review 1.  The assembly, regulation and function of the mitochondrial respiratory chain.

Authors:  Irene Vercellino; Leonid A Sazanov
Journal:  Nat Rev Mol Cell Biol       Date:  2021-10-07       Impact factor: 94.444
  1 in total

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