Literature DB >> 33617512

Not COVID-19, Don't Overlook Pneumocystis in Patients on Gefitinib!

Jérémy Barben1, Valérie Quipourt1, Jérémie Vovelle1, Alain Putot1, Patrick Manckoundia1.   

Abstract

An 82-year-old woman treated for advanced lung cancer with gefitinb was admitted to the emergency unit complaining of dyspnea. Chest computed tomography found abnormalities classified as possible diffuse COVID-19 pneumonia. RT-PCR for Sars-Cov-2 was twice negative. PCR for Pneumocystis jirovecii was positive on bronchoalveolar lavage. The final diagnosis was Pneumocystis jirovecii pneumonia. Therefore, physicians must be careful not to misdiagnose COVID-19, especially in cancer patients on small-molecule therapeutics like gefitinib and corticosteroids.

Entities:  

Keywords:  COVID-19; gefitinib; pneumocystis jirovecii; tyrosine-kinase inhibitor

Mesh：

Substances：

Year:  2021        PMID： 33617512      PMCID： PMC7985782          DOI： 10.3390/curroncol28010094

Source DB:  PubMed          Journal:  Curr Oncol        ISSN： 1198-0052            Impact factor:   3.677


  14 in total

1.  Immunosuppression for Immune Checkpoint-related Toxicity Can Cause Pneumocystis Jirovecii Pneumonia (PJP) in Non-small-cell Lung Cancer (NSCLC): A Report of 2 Cases.

Authors:  Michael Schwarz; Florian Kocher; Dora Niedersuess-Beke; Jakob Rudzki; Maximilian Hochmair; Gerlig Widmann; Wolfgang Hilbe; Andreas Pircher
Journal:  Clin Lung Cancer       Date:  2018-12-19       Impact factor: 4.785

2.  Pneumocystis jirovecii pneumonia and institutional prophylaxis practices in CLL patients treated with BTK inhibitors.

Authors:  Christine E Ryan; Matthew P Cheng; Nicolas C Issa; Jennifer R Brown; Matthew S Davids
Journal:  Blood Adv       Date:  2020-04-14

Review 3.  Does patient age influence anti-cancer immunity?

Authors:  Graham Pawelec
Journal:  Semin Immunopathol       Date:  2018-07-13       Impact factor: 9.623

Review 4.  Clinical, Diagnostic, and Treatment Disparities between HIV-Infected and Non-HIV-Infected Immunocompromised Patients with Pneumocystis jirovecii Pneumonia.

Authors:  Helmut J F Salzer; Guido Schäfer; Martin Hoenigl; Gunar Günther; Christian Hoffmann; Barbara Kalsdorf; Alexandre Alanio; Christoph Lange
Journal:  Respiration       Date:  2018-04-10       Impact factor: 3.580

5.  Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways.

Authors:  Georgios Chamilos; Michail S Lionakis; Dimitrios P Kontoyiannis
Journal:  Clin Infect Dis       Date:  2018-01-06       Impact factor: 9.079

Review 6.  A Stepwise Diagnostic Approach to Cystic Lung Diseases for Radiologists.

Authors:  Kyu Chong Lee; Eun Young Kang; Hwan Seok Yong; Cherry Kim; Ki Yeol Lee; Sung Ho Hwang; Yu Whan Oh
Journal:  Korean J Radiol       Date:  2019-09       Impact factor: 3.500

7.  Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication.

Authors:  Scott Simpson; Fernando U Kay; Suhny Abbara; Sanjeev Bhalla; Jonathan H Chung; Michael Chung; Travis S Henry; Jeffrey P Kanne; Seth Kligerman; Jane P Ko; Harold Litt
Journal:  J Thorac Imaging       Date:  2020-07       Impact factor: 3.000

8.  Dexamethasone in Hospitalized Patients with Covid-19.

Authors:  Peter Horby; Wei Shen Lim; Jonathan R Emberson; Marion Mafham; Jennifer L Bell; Louise Linsell; Natalie Staplin; Christopher Brightling; Andrew Ustianowski; Einas Elmahi; Benjamin Prudon; Christopher Green; Timothy Felton; David Chadwick; Kanchan Rege; Christopher Fegan; Lucy C Chappell; Saul N Faust; Thomas Jaki; Katie Jeffery; Alan Montgomery; Kathryn Rowan; Edmund Juszczak; J Kenneth Baillie; Richard Haynes; Martin J Landray
Journal:  N Engl J Med       Date:  2020-07-17       Impact factor: 91.245

Review 9.  The sensitivity and specificity of chest CT in the diagnosis of COVID-19.

Authors:  Anita Kovács; Péter Palásti; Dániel Veréb; Bence Bozsik; András Palkó; Zsigmond Tamás Kincses
Journal:  Eur Radiol       Date:  2020-10-13       Impact factor: 5.315

Review 10.  Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review.

Authors:  Zheng Ye; Yun Zhang; Yi Wang; Zixiang Huang; Bin Song
Journal:  Eur Radiol       Date:  2020-03-19       Impact factor: 7.034
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  4 in total

Review 1.  COVID-19-associated opportunistic infections: a snapshot on the current reports.

Authors:  Amir Abdoli; Shahab Falahi; Azra Kenarkoohi
Journal:  Clin Exp Med       Date:  2021-08-23       Impact factor: 5.057

2.  Concurrent COVID-19 and pneumocystis carinii pneumonia in a patient subsequently found to have underlying hairy cell leukemia.

Authors:  Vahan Moradians; Bahareh Shateri Amiri; Leyla Bahadorizadeh; Milad Gholizadeh Mesgarha; Shahrzad Sadeghi
Journal:  Radiol Case Rep       Date:  2022-07-02

Review 3.  Concurrent Infection with SARS-CoV-2 and Pneumocystis jirovecii in Immunocompromised and Immunocompetent Individuals.

Authors:  Francesca Gioia; Hanan Albasata; Seyed M Hosseini-Moghaddam
Journal:  J Fungi (Basel)       Date:  2022-05-30

Review 4.  Narrative review of the relationship between COVID-19 and PJP: does it represent coinfection or colonization?

Authors:  Woon H Chong; Biplab K Saha; Amit Chopra
Journal:  Infection       Date:  2021-05-31       Impact factor: 3.553
  4 in total

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