Koichi Masuda1, Shinji Yamazoe2, Akira Baba3, Takuji Mogami2, Satoru Ogane4, Takeshi Nomura4, Hiroya Ojiri3. 1. Department of Radiology, Tokyo Dental College Ichikawa General Hospital, 5-11-13, Sugano, Ichiwaka, Chiba, 272-8513, Japan. masu0205@icloud.com. 2. Department of Radiology, Tokyo Dental College Ichikawa General Hospital, 5-11-13, Sugano, Ichiwaka, Chiba, 272-8513, Japan. 3. Department of Radiology, The Jikei Medical University Hosipital, 3-25-8, Nishishinbashi, Minato-ku, Tokyo, 105-8461, Japan. 4. Oral Cancer Center, Tokyo Dental College Ichikawa General Hospital, 5-11-13, Sugano, Ichiwaka, Chiba, 272-8513, Japan.
Abstract
PURPOSE: To evaluate the efficacy and safety of superselective intra-arterial (IA) chemoradiotherapy with cisplatin and transcatheter arterial embolization (TAE) on advanced oral cancer, and to compare it with that of systemic chemoradiotherapy. MATERIALS AND METHODS: This single-center retrospective study included 23 consecutive patients with locally advanced oral squamous cell carcinoma from November 2011 to November 2019. Of these, 15 received superselective IA cisplatin chemoradiotherapy with altered blood flow in the branches of the external carotid artery, and eight received systemic chemoradiotherapy. Medical charts were reviewed for the evaluation of patient data, drug toxicity, and antitumor efficacy. RESULTS: Local control rate for the superselective IA infusion group, who underwent 6-7 cycles was significantly higher than that of the systemic chemotherapy group (11/13, 85% vs 3/8, 38%; p = 0.04). Regional control, locoregional control, disease-free survival, and overall survival rates were not significantly different between the groups (p = 0.15-0.907). Acute toxicity rates of grade 3 or higher were not significantly different between the IA and IV chemotherapy groups (p = 0.221). CONCLUSION: Superselective IA chemoradiotherapy with cisplatin using altered blood flow in the branches of the external carotid artery with TAE may be useful for inoperable oral cancer.
PURPOSE: To evaluate the efficacy and safety of superselective intra-arterial (IA) chemoradiotherapy with cisplatin and transcatheter arterial embolization (TAE) on advanced oral cancer, and to compare it with that of systemic chemoradiotherapy. MATERIALS AND METHODS: This single-center retrospective study included 23 consecutive patients with locally advanced oral squamous cell carcinoma from November 2011 to November 2019. Of these, 15 received superselective IA cisplatin chemoradiotherapy with altered blood flow in the branches of the external carotid artery, and eight received systemic chemoradiotherapy. Medical charts were reviewed for the evaluation of patient data, drug toxicity, and antitumor efficacy. RESULTS: Local control rate for the superselective IA infusion group, who underwent 6-7 cycles was significantly higher than that of the systemic chemotherapy group (11/13, 85% vs 3/8, 38%; p = 0.04). Regional control, locoregional control, disease-free survival, and overall survival rates were not significantly different between the groups (p = 0.15-0.907). Acute toxicity rates of grade 3 or higher were not significantly different between the IA and IV chemotherapy groups (p = 0.221). CONCLUSION: Superselective IA chemoradiotherapy with cisplatin using altered blood flow in the branches of the external carotid artery with TAE may be useful for inoperable oral cancer.
Authors: Coen R N Rasch; Michael Hauptmann; Jan Schornagel; Oda Wijers; Jan Buter; Theo Gregor; Ruud Wiggenraad; Jan Paul de Boer; Annemiek H Ackerstaff; Robert Kroger; Frank J P Hoebers; Alfons J M Balm; Frans J Hilgers Journal: Cancer Date: 2010-05-01 Impact factor: 6.860