Gayatri B Patel1, Anju T Peters1. 1. Division of Allergy and Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Abstract
BACKGROUND: Severe asthma can be a challenging disease to manage by the provider and by the patient, supported by evidence of increased health-care utilization by this population. Patients with severe asthma should be screened for comorbidities because these often contribute to poorly controlled asthma. The impact of comorbidities, however, are not completely understood. OBJECTIVE: To review common comorbidities and their impact on severe asthma. METHODS: A review of relevant clinical research studies that examined comorbidities in severe or difficult-to-treat asthma. RESULTS: A number of comorbid diseases, including rhinitis, rhinosinusitis, gastroesophageal reflux, and obstructive sleep apnea, are associated with severe or difficult-to-treat asthma. If present and untreated, these conditions may adversely affect asthma control, quality of life, and/or lung function, despite adequate treatment with step-up asthma controller therapy. CONCLUSION: Treatable comorbidities are associated with severe and difficult-to-control asthma. Failure to recognize these comorbidities may divert appropriate care and increase disease burden. Assessment and management of these risk factors may contribute to improved asthma outcome; however, more investigation is needed to understand the relationship of comorbidities and asthma due to inconsistency in the findings.
BACKGROUND: Severe asthma can be a challenging disease to manage by the provider and by the patient, supported by evidence of increased health-care utilization by this population. Patients with severe asthma should be screened for comorbidities because these often contribute to poorly controlled asthma. The impact of comorbidities, however, are not completely understood. OBJECTIVE: To review common comorbidities and their impact on severe asthma. METHODS: A review of relevant clinical research studies that examined comorbidities in severe or difficult-to-treat asthma. RESULTS: A number of comorbid diseases, including rhinitis, rhinosinusitis, gastroesophageal reflux, and obstructive sleep apnea, are associated with severe or difficult-to-treat asthma. If present and untreated, these conditions may adversely affect asthma control, quality of life, and/or lung function, despite adequate treatment with step-up asthma controller therapy. CONCLUSION: Treatable comorbidities are associated with severe and difficult-to-control asthma. Failure to recognize these comorbidities may divert appropriate care and increase disease burden. Assessment and management of these risk factors may contribute to improved asthma outcome; however, more investigation is needed to understand the relationship of comorbidities and asthma due to inconsistency in the findings.
Authors: Janet T Holbrook; Robert A Wise; Benjamin D Gold; Kathryn Blake; Ellen D Brown; Mario Castro; Allen J Dozor; John J Lima; John G Mastronarde; Marianna M Sockrider; W Gerald Teague Journal: JAMA Date: 2012-01-25 Impact factor: 56.272
Authors: Jan L Brożek; Jean Bousquet; Ioana Agache; Arnav Agarwal; Claus Bachert; Sinthia Bosnic-Anticevich; Romina Brignardello-Petersen; G Walter Canonica; Thomas Casale; Niels H Chavannes; Jaime Correia de Sousa; Alvaro A Cruz; Carlos A Cuello-Garcia; Pascal Demoly; Mark Dykewicz; Itziar Etxeandia-Ikobaltzeta; Ivan D Florez; Wytske Fokkens; Joao Fonseca; Peter W Hellings; Ludger Klimek; Sergio Kowalski; Piotr Kuna; Kaja-Triin Laisaar; Désirée E Larenas-Linnemann; Karin C Lødrup Carlsen; Peter J Manning; Eli Meltzer; Joaquim Mullol; Antonella Muraro; Robyn O'Hehir; Ken Ohta; Petr Panzner; Nikolaos Papadopoulos; Hae-Sim Park; Gianni Passalacqua; Ruby Pawankar; David Price; John J Riva; Yetiani Roldán; Dermot Ryan; Behnam Sadeghirad; Boleslaw Samolinski; Peter Schmid-Grendelmeier; Aziz Sheikh; Alkis Togias; Antonio Valero; Arunas Valiulis; Erkka Valovirta; Matthew Ventresca; Dana Wallace; Susan Waserman; Magnus Wickman; Wojtek Wiercioch; Juan José Yepes-Nuñez; Luo Zhang; Yuan Zhang; Mihaela Zidarn; Torsten Zuberbier; Holger J Schünemann Journal: J Allergy Clin Immunol Date: 2017-06-08 Impact factor: 10.793
Authors: Dominick E Shaw; Ana R Sousa; Stephen J Fowler; Louise J Fleming; Graham Roberts; Julie Corfield; Ioannis Pandis; Aruna T Bansal; Elisabeth H Bel; Charles Auffray; Chris H Compton; Hans Bisgaard; Enrica Bucchioni; Massimo Caruso; Pascal Chanez; Barbro Dahlén; Sven-Erik Dahlen; Kerry Dyson; Urs Frey; Thomas Geiser; Maria Gerhardsson de Verdier; David Gibeon; Yi-Ke Guo; Simone Hashimoto; Gunilla Hedlin; Elizabeth Jeyasingham; Pieter-Paul W Hekking; Tim Higenbottam; Ildikó Horváth; Alan J Knox; Norbert Krug; Veit J Erpenbeck; Lars X Larsson; Nikos Lazarinis; John G Matthews; Roelinde Middelveld; Paolo Montuschi; Jacek Musial; David Myles; Laurie Pahus; Thomas Sandström; Wolfgang Seibold; Florian Singer; Karin Strandberg; Jorgen Vestbo; Nadja Vissing; Christophe von Garnier; Ian M Adcock; Scott Wagers; Anthony Rowe; Peter Howarth; Ariane H Wagener; Ratko Djukanovic; Peter J Sterk; Kian Fan Chung Journal: Eur Respir J Date: 2015-09-10 Impact factor: 16.671