Erlin Zhang1,2, Xiaotong Zhao1, Jiali Hu1, Ruoxian Wang1, Shan Fu1, Gaowu Qin1,2. 1. Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, School of Materials Science and Engineering, Northeastern University, Shenyang, 150819, China. 2. Research Center for Metallic Wires, Northeastern University, Shenyang, 110819, China.
Abstract
Metals and alloys, including stainless steel, titanium and its alloys, cobalt alloys, and other metals and alloys have been widely used clinically as implant materials, but implant-related infection or inflammation is still one of the main causes of implantation failure. The bacterial infection or inflammation that seriously threatens human health has already become a worldwide complaint. Antibacterial metals and alloys recently have attracted wide attention for their long-term stable antibacterial ability, good mechanical properties and good biocompatibility in vitro and in vivo. In this review, common antibacterial alloying elements, antibacterial standards and testing methods were introduced. Recent developments in the design and manufacturing of antibacterial metal alloys containing various antibacterial agents were described in detail, including antibacterial stainless steel, antibacterial titanium alloy, antibacterial zinc and alloy, antibacterial magnesium and alloy, antibacterial cobalt alloy, and other antibacterial metals and alloys. Researches on the antibacterial properties, mechanical properties, corrosion resistance and biocompatibility of antibacterial metals and alloys have been summarized in detail for the first time. It is hoped that this review could help researchers understand the development of antibacterial alloys in a timely manner, thereby could promote the development of antibacterial metal alloys and the clinical application.
n class="Chemical">Metals an class="Chemical">nd alloys, including stainless steel, titanium and its alloys, cobaltalloys, and other metals andalloys have been widely used clinically as implant materials, but implant-related infection or inflammation is still one of the main causes of implantation failure. Thebacterial infection or inflammation that seriously threatens humanhealth has already become a worldwide complaint. Antibacterialmetals andalloys recently have attracted wide attention for their long-term stable antibacterial ability, good mechanical properties and good biocompatibility in vitro and in vivo. In this review, common antibacterialalloying elements, antibacterial standards and testing methods were introduced. Recent developments in the design and manufacturing of antibacterialmetalalloys containing various antibacterial agents were described in detail, including antibacterialstainless steel, antibacterialtitaniumalloy, antibacterial zinc andalloy, antibacterialmagnesium andalloy, antibacterialcobaltalloy, and other antibacterialmetals andalloys. Researches on the antibacterial properties, mechanical properties, corrosion resistance and biocompatibility of antibacterialmetals andalloys have been summarized in detail for the first time. It is hoped that this reviewcould help researchers understand the development of antibacterialalloys in a timely manner, thereby could promote the development of antibacterialmetalalloys and theclinical application.