Literature DB >> 33614709

Therapeutic Strategies in the Management of COVID-19.

Rajashri R Naik1, Ashok K Shakya2.   

Abstract

Since December 2019, SARS-CoV-2 (COVID-19), novel corona virus has caused pandemic globally, with rise in the number of cases and death of the patients. Vast majority of the countries that are dealing with rise in the active cases and death of patients suffering from novel corona viruses COVID-19 are trying to content the virus by isolating the patients and treating them with the approved antiviral that have been previously used in treating SARS, MERS, and drugs that are used to treat other viral infections. Some of these are under clinical trials. At present there are no therapeutically effective antiviral present and there are no vaccines or drugs available that are clinically approved for treating the corona virus. The current strategy is to re-purpose the available drugs or antiviral that can minimise or reduce the burden of the health care emergencies. In this article the reuse of antiviral, US-FDA approved drugs, plant based therapeutic, anti-malarial, anti-parasitic, anti-HIV drugs and the traditional medicines that are being currently used in treating the symptoms of COVID-19 patients is discussed emphasis is also given on the treatment using monoclonal antibodies. The present article provides the therapeutic strategies that will qualify as one of the best available treatment for the better management of the COVID-19 patients in order to achieve medical benefits.
Copyright © 2021 Naik and Shakya.

Entities:  

Keywords:  COVID-19; arbidol; chloroquine; favipiravir; hydroxychlorquine; ivermectin; lopinavir/ritonavir; remdesivir

Year:  2021        PMID: 33614709      PMCID: PMC7890447          DOI: 10.3389/fmolb.2020.636738

Source DB:  PubMed          Journal:  Front Mol Biosci        ISSN: 2296-889X


  5 in total

Review 1.  Intervention Strategies for Seasonal and Emerging Respiratory Viruses with Drugs and Vaccines Targeting Viral Surface Glycoproteins.

Authors:  Ralph A Tripp; John Stambas
Journal:  Viruses       Date:  2021-04-06       Impact factor: 5.048

Review 2.  Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of COVID-19.

Authors:  Rajashri R Naik; Ashok K Shakya; Safwan M Aladwan; Mohamed El-Tanani
Journal:  Front Pharmacol       Date:  2022-04-04       Impact factor: 5.988

3.  Investigating the Presence of SARS CoV-2 in Free-Living and Captive Animals.

Authors:  Lorena Jemeršić; Ivana Lojkić; Nina Krešić; Tomislav Keros; Tajana Amšel Zelenika; Luka Jurinović; Damir Skok; Ingeborg Bata; Jadranko Boras; Boris Habrun; Dragan Brnić
Journal:  Pathogens       Date:  2021-05-21

4.  Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients.

Authors:  Agostino Gaudio; Andrea Ruben Murabito; Antonella Agodi; Arturo Montineri; Pietro Castellino
Journal:  Int J Environ Res Public Health       Date:  2021-03-27       Impact factor: 3.390

5.  Sample-Pooling Strategy for SARS-CoV-2 Detection among Students and Staff of the University of Sannio.

Authors:  Immacolata Polvere; Elena Silvestri; Lina Sabatino; Antonia Giacco; Stefania Iervolino; Teresa Peluso; Rosa Guida; Lucrezia Zerillo; Romualdo Varricchio; Silvia D'Andrea; Serena Voccola; Jessica Raffaella Madera; Alberto Zullo; Romania Stilo; Pasquale Vito; Tiziana Zotti
Journal:  Diagnostics (Basel)       Date:  2021-06-26
  5 in total

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