Literature DB >> 33614640

Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis.

Jing Xu1,2, Yan Huang1,2, Jimeng Zhao1,2, Luyi Wu2, Qin Qi1, Yanan Liu1,2, Guona Li1,2, Jing Li1, Huirong Liu1,2, Huangan Wu1,2.   

Abstract

Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Clinical treatment of cancer regarding cofilin has been explored in aspects of tumor cells apoptosis and cofilin related miRNAs. This review addresses the structure and phosphorylation of cofilin and describes recent findings regarding the function of cofilin in regulating cancer metastasis and apoptosis in tumor cells.
Copyright © 2021 Xu, Huang, Zhao, Wu, Qi, Liu, Li, Li, Liu and Wu.

Entities:  

Keywords:  actin-binding protein; apoptosis; cancer metastasis; cofilin; migration

Year:  2021        PMID： 33614640      PMCID： PMC7890941          DOI： 10.3389/fcell.2021.599065

Source DB:  PubMed          Journal:  Front Cell Dev Biol        ISSN： 2296-634X


  5 in total

1.  Fluid shear stress promotes periodontal ligament cells proliferation via p38-AMOT-YAP.

Authors:  Qiusheng Shi; Lisha Zheng; Jing Na; Xinyang Li; Zhijie Yang; Xinyuan Chen; Yaxin Song; Chiyu Li; Lulin Zhou; Yubo Fan
Journal:  Cell Mol Life Sci       Date:  2022-10-16       Impact factor: 9.207

2.  Fetal Zone Steroids Show Discrete Effects on Hyperoxia-Induced Attenuation of Migration in Cultured Oligodendrocyte Progenitor Cells.

Authors:  Donna E Sunny; Elisabeth L Krüger; Elke Hammer; Uwe Völker; Matthias Heckmann
Journal:  Oxid Med Cell Longev       Date:  2022-05-09       Impact factor: 7.310

3.  A Genetic Variant of PPP1CB Influences Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma in Han Chinese: A Pathway Based Analysis.

Authors:  Haoming Mai; Haisheng Xie; Jia Hou; Haitao Chen; Bin Zhou; Jinlin Hou; Deke Jiang
Journal:  J Hepatocell Carcinoma       Date:  2021-09-02

Review 4.  New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis.

Authors:  Carlos García-Padilla; María Del Mar Muñoz-Gallardo; Estefanía Lozano-Velasco; Juan Manuel Castillo-Casas; Sheila Caño-Carrillo; Virginio García-López; Amelia Aránega; Diego Franco; Virginio García-Martínez; Carmen López-Sánchez
Journal:  Noncoding RNA       Date:  2022-04-13

5.  Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination.

Authors:  Vincent Castronovo; Olivier Peulen; Gilles Rademaker; Brunella Costanza; Sébastien Pyr Dit Ruys; Raphaël Peiffer; Ferman Agirman; Naïma Maloujahmoum; Didier Vertommen; Andrei Turtoi; Akeila Bellahcène
Journal:  Oncogenesis       Date:  2022-07-26       Impact factor: 6.524
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.