| Literature DB >> 33614486 |
Ying Tang1,2,3, Mei Jiang4, Hai-Mei Jiang1,2,3, Zeng Jie Ye3, Yu-Sheng Huang2, Xiu-Shen Li1,2,3, Bin-Yu Qin3, Rui-Sheng Zhou1,3, Hua-Feng Pan3, Da-Yong Zheng3,5,6.
Abstract
Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.Entities:
Keywords: circRNA; immune evasion; innate immunity; liver cancer; natural killer (NK) cells
Year: 2021 PMID： 33614486 PMCID： PMC7890029 DOI： 10.3389/fonc.2020.598464
Source DB: PubMed Journal: Front Oncol ISSN： 2234-943X Impact factor: 6.244