Observations by a statistical watchdog.

During more than five decades, the author has kept a critical eye on how statistical methods are (mis-)used in medical research. Some areas are presented where serious statistical mistakes are prevalent. Two investigations with erroneous conclusions are described in detail. Situations where outside authorities have tried to mute medical researchers are also commented upon. The authors own efforts to improve the use of statistical methods and the current situation with easily accessible statistical program packages are described. Finally, the importance of continued 'statistical cleansing' is stressed.