Literature DB >> 33613566

Interleukin-17A Interweaves the Skeletal and Immune Systems.

Mengjia Tang1, Lingyun Lu2, Xijie Yu1.   

Abstract

The complex crosstalk between the immune and the skeletal systems plays an indispensable role in the maintenance of skeletal homeostasis. Various cytokines are involved, including interleukin (IL)-17A. A variety of immune and inflammatory cells produces IL-17A, especially Th17 cells, a subtype of CD4+ T cells. IL-17A orchestrates diverse inflammatory and immune processes. IL-17A induces direct and indirect effects on osteoclasts. The dual role of IL-17A on osteoclasts partly depends on its concentrations and interactions with other factors. Interestingly, IL-17A exerts a dual role in osteoblasts in vitro. IL-17A is a bone-destroying cytokine in numerous immune-mediated bone diseases including postmenopausal osteoporosis (PMOP), rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondylarthritis (axSpA). This review will summarize and discuss the pathophysiological roles of IL-17A on the skeletal system and its potential strategies for application in immune-mediated bone diseases.
Copyright © 2021 Tang, Lu and Yu.

Entities:  

Keywords:  axial spondyloarthritis; interleukin-17A; osteoblasts; osteoclasts; osteoimmunology; postmenopausal osteoporosis; psoriatic arthritis; rheumatoid arthritis

Year:  2021        PMID： 33613566      PMCID： PMC7890031          DOI： 10.3389/fimmu.2020.625034

Source DB:  PubMed          Journal:  Front Immunol        ISSN： 1664-3224            Impact factor:   7.561


  150 in total

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Journal:  Nat Rev Immunol       Date:  2015-11-23       Impact factor: 53.106

2.  IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264.7 cells.

Authors:  Satoshi Kitami; Hideki Tanaka; Takayuki Kawato; Natsuko Tanabe; Tomoko Katono-Tani; Fan Zhang; Naoto Suzuki; Yoshiyuki Yonehara; Masao Maeno
Journal:  Biochimie       Date:  2010-01-04       Impact factor: 4.079

3.  Characterization of IL-17-producing Treg cells in type 2 diabetes patients.

Authors:  Lei Zhu; Haihan Song; Li Zhang; Haiyan Meng
Journal:  Immunol Res       Date:  2019-10       Impact factor: 2.829

4.  Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis.

Authors:  Jing Zhang; Qin Fu; Zhaozhou Ren; Yanjun Wang; Chenchen Wang; Tao Shen; Guangbin Wang; Lina Wu
Journal:  Gynecol Endocrinol       Date:  2014-11-11       Impact factor: 2.260

5.  Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy.

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6.  Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors.

Authors:  Iannis E Adamopoulos; Cheng-Chi Chao; Richard Geissler; Drake Laface; Wendy Blumenschein; Yoichiro Iwakura; Terrill McClanahan; Edward P Bowman
Journal:  Arthritis Res Ther       Date:  2010-02-18       Impact factor: 5.156

7.  Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model.

Authors:  Yu Zhang; Guiping Ren; Mo Guo; Xianlong Ye; Jingzhuang Zhao; Liming Xu; Jianying Qi; Fangming Kan; Miao Liu; Deshan Li
Journal:  Int Immunopharmacol       Date:  2012-12-29       Impact factor: 4.932

8.  Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis.

Authors:  Hui Shen; Jane C Goodall; J S Hill Gaston
Journal:  Arthritis Rheum       Date:  2009-06

9.  IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling.

Authors:  H Huang; H J Kim; E-J Chang; Z H Lee; S J Hwang; H-M Kim; Y Lee; H-H Kim
Journal:  Cell Death Differ       Date:  2009-06-19       Impact factor: 15.828

10.  IL-17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH-Induced Bone Loss and Enhances Osteocytic RANKL Production.

Authors:  Jau-Yi Li; Mingcan Yu; Abdul Malik Tyagi; Chiara Vaccaro; Emory Hsu; Jonathan Adams; Teresita Bellido; M Neale Weitzmann; Roberto Pacifici
Journal:  J Bone Miner Res       Date:  2018-11-06       Impact factor: 6.741
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  11 in total

Review 1.  Osteoblast role in the pathogenesis of rheumatoid arthritis.

Authors:  S Berardi; A Corrado; N Maruotti; D Cici; F P Cantatore
Journal:  Mol Biol Rep       Date:  2021-03-27       Impact factor: 2.316

2.  Targeting MyD88 Downregulates Inflammatory Mediators and Pathogenic Processes in PBMC From DMARDs-Naïve Rheumatoid Arthritis Patients.

Authors:  Sergio Ramirez-Perez; Edith Oregon-Romero; Itzel Viridiana Reyes-Perez; Pallavi Bhattaram
Journal:  Front Pharmacol       Date:  2021-12-23       Impact factor: 5.810

3.  Gut Microbiota and Serum Metabolic Signatures of High-Fat-Induced Bone Loss in Mice.

Authors:  Lingyun Lu; Mengjia Tang; Jiao Li; Ying Xie; Yujue Li; Jinwei Xie; Li Zhou; Yi Liu; Xijie Yu
Journal:  Front Cell Infect Microbiol       Date:  2021-12-22       Impact factor: 5.293

4.  Genome analysis identifies differences in the transcriptional targets of duodenal versus pancreatic neuroendocrine tumours.

Authors:  Karen Rico; Suzann Duan; Ritu L Pandey; Yuliang Chen; Jayati T Chakrabarti; Julie Starr; Yana Zavros; Tobias Else; Bryson W Katona; David C Metz; Juanita L Merchant
Journal:  BMJ Open Gastroenterol       Date:  2021-11

Review 5.  Effects of Biological/Targeted Therapies on Bone Mineral Density in Inflammatory Arthritis.

Authors:  Tai-Li Chen; Kai-Hung Chang; Kuei-Ying Su
Journal:  Int J Mol Sci       Date:  2022-04-08       Impact factor: 6.208

6.  High serum IL-17A is associated with bone destruction in newly diagnosed multiple myeloma patients.

Authors:  Mengmeng Dong; Jinna Zhang; Qingxiao Chen; Donghua He; Haimeng Yan; Gaofeng Zheng; Xiaoyan Han; Jingsong He; Zhen Cai
Journal:  Front Oncol       Date:  2022-08-31       Impact factor: 5.738

Review 7.  Role of the major histocompatibility complex class II protein presentation pathway in bone immunity imbalance in postmenopausal osteoporosis.

Authors:  Xiaoning Wang; Xin Zhang; Yidan Han; Xinwei Duan; Jianchang Wang; Hui Yan; Shanshan Wang; Yunteng Xu; Zaishi Zhu; Lili Wang; Yanfeng Huang; Qing Lin; Xue Tan; Junkuan Zhuo; Haifeng Zhang; Min Mao; Weiying Gou; Zhouping Yi; Xihai Li
Journal:  Front Endocrinol (Lausanne)       Date:  2022-08-11       Impact factor: 6.055

8.  New Insights into the Regulatory Role of Ferroptosis in Ankylosing Spondylitis via Consensus Clustering of Ferroptosis-Related Genes and Weighted Gene Co-Expression Network Analysis.

Authors:  Tianhua Rong; Ningyi Jia; Bingxuan Wu; Dacheng Sang; Baoge Liu
Journal:  Genes (Basel)       Date:  2022-07-31       Impact factor: 4.141

Review 9.  T-Cell Mediated Inflammation in Postmenopausal Osteoporosis.

Authors:  Di Wu; Anna Cline-Smith; Elena Shashkova; Ajit Perla; Aditya Katyal; Rajeev Aurora
Journal:  Front Immunol       Date:  2021-06-30       Impact factor: 7.561

Review 10.  The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients.

Authors:  Apurva Hariharan; Abdul Rahman Hakeem; Subathra Radhakrishnan; Mettu Srinivas Reddy; Mohamed Rela
Journal:  Inflammopharmacology       Date:  2020-11-07       Impact factor: 4.473
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